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GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.

Term Information

ID GO:0004653
Name polypeptide N-acetylgalactosaminyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.
Comment

Synonyms

Type Synonym
exact protein-UDP acetylgalactosaminyltransferase activity
exact UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity
exact UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
exact UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity
exact UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity
exact glycoprotein acetylgalactosaminyltransferase activity
exact UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity
exact UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity
exact UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity
exact UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity
exact UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity
exact UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity
exact UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
exact polypeptide-N-acetylgalactosamine transferase activity
exact uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity

Cross-references associated with this term:

Database ID
MetaCyc 2.4.1.41-RXN
EC 2.4.1.41

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0008194 UDP-glycosyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0008376 acetylgalactosaminyltransferase activity
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity

Relationship key

Code Relationship
part of
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regulates
+ve regulates
-ve regulates

Child Terms

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Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
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Taxonomy
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Co-occurring Terms

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