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GO:0004623 phospholipase A2 activity

Term Information

ID GO:0004623
Name phospholipase A2 activity
Ontology Molecular Function
Definition Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
GONUTS GO:0004623 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow secreted phospholipase A2 activity
exact phosphatidylcholine 2-acylhydrolase activity
exact phosphatidolipase activity
related phosphatidase activity
exact lecithinase A activity
related phospholipase A
narrow cytosolic phospholipase A2 activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.1.4
InterPro IPR001211
InterPro IPR010711
InterPro IPR013090
MetaCyc PHOSPHOLIPASE-A2-RXN
RHEA 15804

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004624 secreted phospholipase A2 activity REPLACEDBY GO:0004623
GO:0004626 cytosolic phospholipase A2 activity REPLACEDBY GO:0004623

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004623:
Relationship To GO:0004623 Child Term Child Term Name
Is a GO:0047498 calcium-dependent phospholipase A2 activity
Is a GO:0047499 calcium-independent phospholipase A2 activity
Positively regulates GO:0016005 phospholipase A2 activator activity
Negatively regulates GO:0019834 phospholipase A2 inhibitor activity
Regulates GO:0032429 regulation of phospholipase A2 activity
Positively regulates GO:0032430 positive regulation of phospholipase A2 activity
Negatively regulates GO:1900138 negative regulation of phospholipase A2 activity

Protein Annotation

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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004623. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004623 based on the entire annotation set Co-occurrence statistics for GO:0004623 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:15804
2011-05-03 Added RELATION is a GO:0052689 (carboxylic ester hydrolase activity)
2011-05-03 Deleted RELATION is a GO:0004091 (carboxylesterase activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2008-04-01 Updated RELATION is a GO:0004091 (carboxylesterase activity)
2008-04-01 Updated RELATION is a GO:0004620 (phospholipase activity)
2008-04-01 Deleted SYNONYM phospholipase A2 activity
2007-12-14 Added SYNONYM phospholipase A
2007-10-01 Added SYNONYM phospholipase A2 activity
2007-09-10 Deleted SYNONYM phospholipase A2 activity
2007-09-06 Added SYNONYM lecithinase A activity
2007-09-06 Added SYNONYM phosphatidase activity
2007-09-06 Added SYNONYM phosphatidolipase activity
2007-09-06 Added SYNONYM phosphatidylcholine 2-acylhydrolase activity
2007-09-06 Added SYNONYM phospholipase A2 activity
2007-08-09 Added SYNONYM cytosolic phospholipase A2 activity
2007-08-09 Added SYNONYM secreted phospholipase A2 activity
2007-08-09 Deleted SYNONYM cytosolic phospholipase A2 activity
2007-08-09 Deleted SYNONYM secreted phospholipase A2 activity
2005-08-10 Added SYNONYM cytosolic phospholipase A2 activity
2005-08-10 Added SYNONYM secreted phospholipase A2 activity
2003-10-27 Added XREF MetaCyc:PHOSPHOLIPASE-A2-RXN
2003-08-29 Updated DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2003-03-19 Updated TERM phospholipase A2 activity
2002-11-27 Added DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
2002-02-06 Updated TERM phospholipase A2
2001-04-03 Updated TERM phospholipase A2
2001-03-30 Added XREF EC:3.1.1.4
2001-03-30 Added TERM phospholipase A2

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM phospholipase A2 activity
2002-02-06 Updated TERM phospholipase A2
2001-04-03 Updated TERM phospholipase A2
2001-03-30 Added TERM phospholipase A2

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2008-04-01 Deleted SYNONYM phospholipase A2 activity
2007-12-14 Added SYNONYM phospholipase A
2007-10-01 Added SYNONYM phospholipase A2 activity
2007-09-10 Deleted SYNONYM phospholipase A2 activity
2007-09-06 Added SYNONYM lecithinase A activity
2007-09-06 Added SYNONYM phosphatidase activity
2007-09-06 Added SYNONYM phosphatidolipase activity
2007-09-06 Added SYNONYM phosphatidylcholine 2-acylhydrolase activity
2007-09-06 Added SYNONYM phospholipase A2 activity
2007-08-09 Added SYNONYM cytosolic phospholipase A2 activity
2007-08-09 Added SYNONYM secreted phospholipase A2 activity
2007-08-09 Deleted SYNONYM cytosolic phospholipase A2 activity
2007-08-09 Deleted SYNONYM secreted phospholipase A2 activity
2005-08-10 Added SYNONYM cytosolic phospholipase A2 activity
2005-08-10 Added SYNONYM secreted phospholipase A2 activity
2003-08-29 Updated DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2002-11-27 Added DEFINITION Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

Relationships

Timestamp Action Category Detail
2011-05-03 Added RELATION is a GO:0052689 (carboxylic ester hydrolase activity)
2011-05-03 Deleted RELATION is a GO:0004091 (carboxylesterase activity)
2008-04-01 Updated RELATION is a GO:0004091 (carboxylesterase activity)
2008-04-01 Updated RELATION is a GO:0004620 (phospholipase activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:15804
2003-10-27 Added XREF MetaCyc:PHOSPHOLIPASE-A2-RXN
2001-03-30 Added XREF EC:3.1.1.4
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