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GO:0004528 phosphodiesterase I activity

Term Information

ID GO:0004528
Name phosphodiesterase I activity
Ontology Molecular Function
Definition Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
GONUTS GO:0004528 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact oligonucleate 5'-nucleotidohydrolase activity
exact orthophosphoric diester phosphohydrolase activity
broad phosphodiesterase activity
related 5'-nucleotide phosphodiesterase activity
exact 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
related 5'-exonuclease activity
related 5'-PDase activity
related 5'-PDE activity
related 5'-NPDase activity
related alkaline phosphodiesterase activity
related exonuclease I activity
related 5'-phosphodiesterase activity
exact nucleotide pyrophosphatase/phosphodiesterase I activity
exact PDE I activity
related 5'NPDE activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.4.1
MetaCyc 3.1.4.1-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004528:
Relationship To GO:0004528 Child Term Child Term Name
Regulates GO:1902799 regulation of phosphodiesterase I activity
Positively regulates GO:1902800 positive regulation of phosphodiesterase I activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004528. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004528 based on the entire annotation set Co-occurrence statistics for GO:0004528 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
2008-05-12 Deleted DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
2008-04-01 Updated RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2008-04-01 Updated RELATION is a GO:0004527 (exonuclease activity)
2007-09-06 Added SYNONYM exonuclease I activity
2007-09-06 Added SYNONYM nucleotide pyrophosphatase/phosphodiesterase I activity
2007-09-06 Added SYNONYM oligonucleate 5'-nucleotidohydrolase activity
2007-09-06 Added SYNONYM orthophosphoric diester phosphohydrolase activity
2007-09-06 Added SYNONYM phosphodiesterase activity
2007-09-06 Added SYNONYM 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
2007-09-06 Added SYNONYM 5'-NPDase activity
2007-09-06 Added SYNONYM 5'-PDE activity
2007-09-06 Added SYNONYM 5'-PDase activity
2007-09-06 Added SYNONYM 5'-exonuclease activity
2007-09-06 Added SYNONYM 5'-nucleotide phosphodiesterase activity
2007-09-06 Added SYNONYM 5'-phosphodiesterase activity
2007-09-06 Added SYNONYM 5'NPDE activity
2007-09-06 Added SYNONYM PDE I activity
2007-09-06 Added SYNONYM alkaline phosphodiesterase activity
2003-10-27 Added XREF MetaCyc:3.1.4.1-RXN
2003-04-24 Updated DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
2003-03-26 Updated DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligo-nucleotides.
2003-03-19 Updated TERM phosphodiesterase I activity
2002-11-27 Added DEFINITION Catalysis of the reaction: hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligo-nucleotides.
2002-02-06 Updated TERM phosphodiesterase I
2001-04-03 Updated TERM phosphodiesterase I
2001-03-30 Added XREF EC:3.1.4.1
2001-03-30 Added TERM phosphodiesterase I

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM phosphodiesterase I activity
2002-02-06 Updated TERM phosphodiesterase I
2001-04-03 Updated TERM phosphodiesterase I
2001-03-30 Added TERM phosphodiesterase I

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
2008-05-12 Deleted DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
2007-09-06 Added SYNONYM exonuclease I activity
2007-09-06 Added SYNONYM nucleotide pyrophosphatase/phosphodiesterase I activity
2007-09-06 Added SYNONYM oligonucleate 5'-nucleotidohydrolase activity
2007-09-06 Added SYNONYM orthophosphoric diester phosphohydrolase activity
2007-09-06 Added SYNONYM phosphodiesterase activity
2007-09-06 Added SYNONYM 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
2007-09-06 Added SYNONYM 5'-NPDase activity
2007-09-06 Added SYNONYM 5'-PDE activity
2007-09-06 Added SYNONYM 5'-PDase activity
2007-09-06 Added SYNONYM 5'-exonuclease activity
2007-09-06 Added SYNONYM 5'-nucleotide phosphodiesterase activity
2007-09-06 Added SYNONYM 5'-phosphodiesterase activity
2007-09-06 Added SYNONYM 5'NPDE activity
2007-09-06 Added SYNONYM PDE I activity
2007-09-06 Added SYNONYM alkaline phosphodiesterase activity
2003-04-24 Updated DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
2003-03-26 Updated DEFINITION Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligo-nucleotides.
2002-11-27 Added DEFINITION Catalysis of the reaction: hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligo-nucleotides.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2008-04-01 Updated RELATION is a GO:0004527 (exonuclease activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.1.4.1-RXN
2001-03-30 Added XREF EC:3.1.4.1
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