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GO:0004527 exonuclease activity

Term Information

ID GO:0004527
Name exonuclease activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
Secondary IDs GO:0008857
GONUTS GO:0004527 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow exonuclease IX activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR001616
InterPro IPR003701
InterPro IPR004859
InterPro IPR006055
UniProtKB-KW Exonuclease

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004527:
Relationship To GO:0004527 Child Term Child Term Name
Is a GO:0004528 phosphodiesterase I activity
Is a GO:0004529 exodeoxyribonuclease activity
Is a GO:0004532 exoribonuclease activity
Is a GO:0008408 3'-5' exonuclease activity
Is a GO:0008409 5'-3' exonuclease activity
Is a GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
Is a GO:0016797 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Symbol
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004527. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004527 based on the entire annotation set Co-occurrence statistics for GO:0004527 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-17 Added SYNONYM exonuclease IX activity
2010-10-17 Added SECONDARY GO:0008857 (exonuclease IX activity)
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2003-03-19 Updated TERM exonuclease activity
2002-02-06 Updated TERM exonuclease
2001-08-06 Added DEFINITION Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2001-04-03 Updated TERM exonuclease
2001-03-30 Added TERM exonuclease

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM exonuclease activity
2002-02-06 Updated TERM exonuclease
2001-04-03 Updated TERM exonuclease
2001-03-30 Added TERM exonuclease

Definition/synonyms

Timestamp Action Category Detail
2010-10-17 Added SYNONYM exonuclease IX activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
2001-08-06 Added DEFINITION Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)

Other

Timestamp Action Category Detail
2010-10-17 Added SECONDARY GO:0008857 (exonuclease IX activity)
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