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GO:0004525 ribonuclease III activity

Term Information

ID GO:0004525
Name ribonuclease III activity
Ontology Molecular Function
Definition Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
PMID:11157775 PMID:15242644
GONUTS GO:0004525 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow pre-mRNA 3'-end processing endonuclease
exact ribonuclease 3 activity
exact RNase III activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.26.3
InterPro IPR000999
InterPro IPR011907
MetaCyc 3.1.26.3-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004525:
Relationship To GO:0004525 Child Term Child Term Name
Is a GO:0016443 bidentate ribonuclease III activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004525. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004525 based on the entire annotation set Co-occurrence statistics for GO:0004525 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-01-21 Added RELATION is a GO:0032296 (double-stranded RNA-specific ribonuclease activity)
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2008-04-01 Updated RELATION is a GO:0016891 (endoribonuclease activity, producing 5'-phosphomonoesters)
2007-09-06 Added SYNONYM RNase III activity
2007-09-06 Added SYNONYM ribonuclease 3 activity
2007-08-09 Added SYNONYM pre-mRNA 3'-end processing endonuclease
2007-08-09 Deleted SYNONYM pre-mRNA 3'-end processing endonuclease
2007-01-18 Added SYNONYM pre-mRNA 3'-end processing endonuclease
2006-02-03 Updated DEFINITION Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2003-10-27 Added XREF MetaCyc:3.1.26.3-RXN
2003-03-19 Updated TERM ribonuclease III activity
2002-11-27 Updated DEFINITION Catalysis of the endonucleolytic cleavage of RNA to 5'-phosphomonoesters; cleaves multimeric tRNA precursor at the spacer region; also involved in processing of precursor rRNA, hnRNA and early T7-mRNA; also cleaves double-stranded DNA.
2002-02-06 Updated TERM ribonuclease III
2001-08-06 Added DEFINITION Enzyme that catalyzes the endonucleolytic cleavage of RNA to 5'-phosphomonoesters; cleaves multimeric tRNA precursor at the spacer region; also involved in processing of precursor rRNA, hnRNA and early T7-mRNA; also cleaves double-stranded DNA.
2001-04-03 Updated TERM ribonuclease III
2001-03-30 Added XREF EC:3.1.26.3
2001-03-30 Added TERM ribonuclease III

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM ribonuclease III activity
2002-02-06 Updated TERM ribonuclease III
2001-04-03 Updated TERM ribonuclease III
2001-03-30 Added TERM ribonuclease III

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2007-09-06 Added SYNONYM RNase III activity
2007-09-06 Added SYNONYM ribonuclease 3 activity
2007-08-09 Added SYNONYM pre-mRNA 3'-end processing endonuclease
2007-08-09 Deleted SYNONYM pre-mRNA 3'-end processing endonuclease
2007-01-18 Added SYNONYM pre-mRNA 3'-end processing endonuclease
2006-02-03 Updated DEFINITION Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
2002-11-27 Updated DEFINITION Catalysis of the endonucleolytic cleavage of RNA to 5'-phosphomonoesters; cleaves multimeric tRNA precursor at the spacer region; also involved in processing of precursor rRNA, hnRNA and early T7-mRNA; also cleaves double-stranded DNA.
2001-08-06 Added DEFINITION Enzyme that catalyzes the endonucleolytic cleavage of RNA to 5'-phosphomonoesters; cleaves multimeric tRNA precursor at the spacer region; also involved in processing of precursor rRNA, hnRNA and early T7-mRNA; also cleaves double-stranded DNA.

Relationships

Timestamp Action Category Detail
2014-01-21 Added RELATION is a GO:0032296 (double-stranded RNA-specific ribonuclease activity)
2008-04-01 Updated RELATION is a GO:0016891 (endoribonuclease activity, producing 5'-phosphomonoesters)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.1.26.3-RXN
2001-03-30 Added XREF EC:3.1.26.3
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