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GO:0004523 RNA-DNA hybrid ribonuclease activity

Term Information

ID GO:0004523
Name RNA-DNA hybrid ribonuclease activity
Ontology Molecular Function
Definition Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
Comment Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
Secondary IDs GO:0004524
GONUTS GO:0004523 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact ribonuclease H activity
narrow endoribonuclease0 H activity
related endoribonuclease H
related endoribonuclease H (calf thymus)
exact hybrid nuclease activity
exact hybrid ribonuclease activity
exact hybridase (ribonuclease H)
exact hybridase activity
exact RNA*DNA hybrid ribonucleotidohydrolase activity
exact RNase H activity
narrow RNase H1 activity
narrow RNase H2 activity
narrow RNase H3 activity
exact calf thymus ribonuclease H activity
narrow ribonuclease H1 activity
narrow ribonuclease H2 activity
narrow ribonuclease H3 activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.26.4
InterPro IPR001352
InterPro IPR001462
InterPro IPR002156
InterPro IPR004641
InterPro IPR004649
InterPro IPR017067
InterPro IPR017290
InterPro IPR020787
InterPro IPR021639
InterPro IPR022892
InterPro IPR022898
InterPro IPR023160
MetaCyc 3.1.26.4-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004523:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004523. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004523 based on the entire annotation set Co-occurrence statistics for GO:0004523 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-15 Updated TERM RNA-DNA hybrid ribonuclease activity
2013-12-15 Added SYNONYM ribonuclease H activity
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2008-04-01 Updated RELATION is a GO:0016891 (endoribonuclease activity, producing 5'-phosphomonoesters)
2007-11-08 Added SYNONYM RNA*DNA hybrid ribonucleotidohydrolase activity
2007-11-08 Added SYNONYM endoribonuclease H
2007-11-08 Added SYNONYM endoribonuclease H (calf thymus)
2007-11-08 Added SYNONYM hybrid nuclease activity
2007-11-08 Added SYNONYM hybrid ribonuclease activity
2007-11-08 Added SYNONYM hybridase (ribonuclease H)
2007-11-08 Added SYNONYM hybridase activity
2007-09-06 Added SYNONYM endoribonuclease0 H activity
2007-08-09 Added SYNONYM RNase H activity
2007-08-09 Added SYNONYM RNase H1 activity
2007-08-09 Added SYNONYM RNase H2 activity
2007-08-09 Added SYNONYM RNase H3 activity
2007-08-09 Added SYNONYM calf thymus ribonuclease H activity
2007-08-09 Added SYNONYM ribonuclease H1 activity
2007-08-09 Added SYNONYM ribonuclease H2 activity
2007-08-09 Added SYNONYM ribonuclease H3 activity
2007-08-09 Deleted SYNONYM RNase H activity
2007-08-09 Deleted SYNONYM RNase H1 activity
2007-08-09 Deleted SYNONYM RNase H2 activity
2007-08-09 Deleted SYNONYM RNase H3 activity
2007-08-09 Deleted SYNONYM calf thymus ribonuclease H activity
2007-08-09 Deleted SYNONYM ribonuclease H1 activity
2007-08-09 Deleted SYNONYM ribonuclease H2 activity
2007-08-09 Deleted SYNONYM ribonuclease H3 activity
2006-10-01 Added SYNONYM RNase H1 activity
2006-10-01 Added SYNONYM RNase H2 activity
2006-10-01 Added SYNONYM RNase H3 activity
2006-09-30 Added SECONDARY GO:0004524 (ribonuclease H1 activity)
2006-09-30 Added SYNONYM ribonuclease H1 activity
2006-09-30 Added SYNONYM ribonuclease H2 activity
2006-09-30 Added SYNONYM ribonuclease H3 activity
2004-07-12 Deleted SYNONYM ribonuclease H activity
2004-07-12 Added SYNONYM RNase H activity
2004-04-19 Added SYNONYM calf thymus ribonuclease H activity
2004-04-19 Added SYNONYM ribonuclease H activity
2004-04-16 Deleted SYNONYM calf thymus ribonuclease H activity
2004-04-16 Deleted SYNONYM ribonuclease H activity
2004-01-10 Added SYNONYM calf thymus ribonuclease H activity
2004-01-10 Updated TERM ribonuclease H activity
2004-01-07 Updated TERM calf thymus ribonuclease H activity
2004-01-07 Added SYNONYM ribonuclease H activity
2003-10-27 Added XREF MetaCyc:3.1.26.4-RXN
2003-03-19 Updated TERM ribonuclease H activity
2002-11-27 Updated DEFINITION Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2002-02-06 Updated TERM ribonuclease H
2001-08-06 Added DEFINITION Enzyme that catalyzes the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2001-04-03 Updated TERM ribonuclease H
2001-03-30 Added XREF EC:3.1.26.4
2001-03-30 Added TERM ribonuclease H

Term

Timestamp Action Category Detail
2013-12-15 Updated TERM RNA-DNA hybrid ribonuclease activity
2004-01-10 Updated TERM ribonuclease H activity
2004-01-07 Updated TERM calf thymus ribonuclease H activity
2003-03-19 Updated TERM ribonuclease H activity
2002-02-06 Updated TERM ribonuclease H
2001-04-03 Updated TERM ribonuclease H
2001-03-30 Added TERM ribonuclease H

Definition/synonyms

Timestamp Action Category Detail
2013-12-15 Added SYNONYM ribonuclease H activity
2008-05-13 Added DEFINITION Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2008-05-12 Deleted DEFINITION Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2007-11-08 Added SYNONYM RNA*DNA hybrid ribonucleotidohydrolase activity
2007-11-08 Added SYNONYM endoribonuclease H
2007-11-08 Added SYNONYM endoribonuclease H (calf thymus)
2007-11-08 Added SYNONYM hybrid nuclease activity
2007-11-08 Added SYNONYM hybrid ribonuclease activity
2007-11-08 Added SYNONYM hybridase (ribonuclease H)
2007-11-08 Added SYNONYM hybridase activity
2007-09-06 Added SYNONYM endoribonuclease0 H activity
2007-08-09 Added SYNONYM RNase H activity
2007-08-09 Added SYNONYM RNase H1 activity
2007-08-09 Added SYNONYM RNase H2 activity
2007-08-09 Added SYNONYM RNase H3 activity
2007-08-09 Added SYNONYM calf thymus ribonuclease H activity
2007-08-09 Added SYNONYM ribonuclease H1 activity
2007-08-09 Added SYNONYM ribonuclease H2 activity
2007-08-09 Added SYNONYM ribonuclease H3 activity
2007-08-09 Deleted SYNONYM RNase H activity
2007-08-09 Deleted SYNONYM RNase H1 activity
2007-08-09 Deleted SYNONYM RNase H2 activity
2007-08-09 Deleted SYNONYM RNase H3 activity
2007-08-09 Deleted SYNONYM calf thymus ribonuclease H activity
2007-08-09 Deleted SYNONYM ribonuclease H1 activity
2007-08-09 Deleted SYNONYM ribonuclease H2 activity
2007-08-09 Deleted SYNONYM ribonuclease H3 activity
2006-10-01 Added SYNONYM RNase H1 activity
2006-10-01 Added SYNONYM RNase H2 activity
2006-10-01 Added SYNONYM RNase H3 activity
2006-09-30 Added SYNONYM ribonuclease H1 activity
2006-09-30 Added SYNONYM ribonuclease H2 activity
2006-09-30 Added SYNONYM ribonuclease H3 activity
2004-07-12 Deleted SYNONYM ribonuclease H activity
2004-07-12 Added SYNONYM RNase H activity
2004-04-19 Added SYNONYM calf thymus ribonuclease H activity
2004-04-19 Added SYNONYM ribonuclease H activity
2004-04-16 Deleted SYNONYM calf thymus ribonuclease H activity
2004-04-16 Deleted SYNONYM ribonuclease H activity
2004-01-10 Added SYNONYM calf thymus ribonuclease H activity
2004-01-07 Added SYNONYM ribonuclease H activity
2002-11-27 Updated DEFINITION Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
2001-08-06 Added DEFINITION Enzyme that catalyzes the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016891 (endoribonuclease activity, producing 5'-phosphomonoesters)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.1.26.4-RXN
2001-03-30 Added XREF EC:3.1.26.4

Other

Timestamp Action Category Detail
2006-09-30 Added SECONDARY GO:0004524 (ribonuclease H1 activity)
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