spacer

GO:0004519 endonuclease activity

Term Information

ID GO:0004519
Name endonuclease activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
GONUTS GO:0004519 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR001044
InterPro IPR001982
InterPro IPR002711
InterPro IPR003060
InterPro IPR003154
InterPro IPR004042
InterPro IPR004230
InterPro IPR004579
InterPro IPR004593
InterPro IPR004601
InterPro IPR004603
InterPro IPR004613
InterPro IPR004860
InterPro IPR006167
InterPro IPR006350
InterPro IPR007281
InterPro IPR007409
InterPro IPR007560
InterPro IPR007581
InterPro IPR007869
InterPro IPR009614
InterPro IPR009933
InterPro IPR010270
InterPro IPR011337
InterPro IPR013396
InterPro IPR020847
InterPro IPR020848
InterPro IPR023520
InterPro IPR023713
InterPro IPR024622
InterPro IPR027434
InterPro IPR028629
UniProtKB-KW Endonuclease

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008845 endonuclease VIII activity CONSIDER GO:0004519
GO:0016541 intein CONSIDER GO:0004519

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004519:
Relationship To GO:0004519 Child Term Child Term Name
Is a GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
Is a GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
Is a GO:0004520 endodeoxyribonuclease activity
Is a GO:0004521 endoribonuclease activity
Is a GO:0043765 T/G mismatch-specific endonuclease activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004519. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004519 based on the entire annotation set Co-occurrence statistics for GO:0004519 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)
2007-10-16 Deleted SYNONYM intein
2007-09-10 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM intein
2007-08-09 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM intein
2005-08-10 Added SYNONYM endonuclease VIII activity
2005-08-10 Added SYNONYM intein
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2003-03-19 Updated TERM endonuclease activity
2002-02-06 Updated TERM endonuclease
2001-08-06 Added DEFINITION Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2001-04-03 Updated TERM endonuclease
2001-03-30 Added TERM endonuclease

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM endonuclease activity
2002-02-06 Updated TERM endonuclease
2001-04-03 Updated TERM endonuclease
2001-03-30 Added TERM endonuclease

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2007-10-16 Deleted SYNONYM intein
2007-09-10 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM intein
2007-08-09 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Deleted SYNONYM intein
2005-08-10 Added SYNONYM endonuclease VIII activity
2005-08-10 Added SYNONYM intein
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
2001-08-06 Added DEFINITION Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004518 (nuclease activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
11ms