spacer

GO:0004518 nuclease activity

Term Information

ID GO:0004518
Name nuclease activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of ester linkages within nucleic acids.
Comment Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
GONUTS GO:0004518 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_generic149
goslim_plant100
goslim_yeast169
goslim_chembl309

Cross-references

Database ID
EC 3.1.-.-
InterPro IPR002071
InterPro IPR003729
InterPro IPR004808
InterPro IPR006084
InterPro IPR006085
InterPro IPR006086
InterPro IPR006166
InterPro IPR007346
InterPro IPR011604
InterPro IPR011805
InterPro IPR011856
InterPro IPR012585
InterPro IPR020819
InterPro IPR027050
InterPro IPR027521
UniProtKB-KW Excision nuclease
UniProtKB-KW Nuclease

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004518:
Relationship To GO:0004518 Child Term Child Term Name
Is a GO:0004519 endonuclease activity
Is a GO:0004527 exonuclease activity
Is a GO:0004536 deoxyribonuclease activity
Is a GO:0004540 ribonuclease activity
Is a GO:0008946 oligonucleotidase activity
Regulates GO:0032069 regulation of nuclease activity
Negatively regulates GO:0032074 negative regulation of nuclease activity
Positively regulates GO:0032075 positive regulation of nuclease activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004518. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004518 based on the entire annotation set Co-occurrence statistics for GO:0004518 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_plant
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2012-01-26 Added RELATION part of GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
2011-08-14 Added SLIM goslim_yeast
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_generic
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids.
2008-04-01 Updated RELATION is a GO:0016788 (hydrolase activity, acting on ester bonds)
2003-03-19 Updated TERM nuclease activity
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids.
2002-02-06 Updated TERM nuclease
2001-08-06 Added DEFINITION Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids.
2001-04-03 Updated TERM nuclease
2001-03-30 Added XREF EC:3.1.-.-
2001-03-30 Added TERM nuclease

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM nuclease activity
2002-02-06 Updated TERM nuclease
2001-04-03 Updated TERM nuclease
2001-03-30 Added TERM nuclease

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids.
2002-11-27 Updated DEFINITION Catalysis of the hydrolysis of ester linkages within nucleic acids.
2001-08-06 Added DEFINITION Any enzyme that catalyzes the hydrolysis of ester linkages within nucleic acids.

Relationships

Timestamp Action Category Detail
2012-01-26 Added RELATION part of GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
2008-04-01 Updated RELATION is a GO:0016788 (hydrolase activity, acting on ester bonds)

Cross-references

Timestamp Action Category Detail
2001-03-30 Added XREF EC:3.1.-.-

Other

Timestamp Action Category Detail
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_plant
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-08-14 Added SLIM goslim_yeast
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_generic
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
18ms