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GO:0004517 nitric-oxide synthase activity

Term Information

ID GO:0004517
Name nitric-oxide synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
GONUTS GO:0004517 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NO synthase activity
related endothelium-derived relaxation factor-forming enzyme activity
exact nitric oxide synthase activity
exact nitric-oxide synthetase activity
exact nitric oxide synthetase activity
exact NADPH-diaphorase activity
related endothelium-derived relaxing factor synthase activity
exact L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.14.13.39
InterPro IPR004030
InterPro IPR012144
InterPro IPR017142
MetaCyc NITRIC-OXIDE-SYNTHASE-RXN
RHEA 24668

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004517:
Relationship To GO:0004517 Child Term Child Term Name
Regulates GO:0030235 nitric-oxide synthase regulator activity
Regulates GO:0050999 regulation of nitric-oxide synthase activity
Positively regulates GO:0051000 positive regulation of nitric-oxide synthase activity
Negatively regulates GO:0051001 negative regulation of nitric-oxide synthase activity
Capable of GO:1903958 nitric-oxide synthase complex
Negatively regulates GO:0036487 nitric-oxide synthase inhibitor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004517. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004517 based on the entire annotation set Co-occurrence statistics for GO:0004517 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:24668
2008-05-13 Added DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
2008-04-01 Updated RELATION is a GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
2007-12-14 Added SYNONYM L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
2007-12-14 Added SYNONYM nitric oxide synthetase activity
2007-09-06 Added SYNONYM NADPH-diaphorase activity
2007-09-06 Added SYNONYM NO synthase activity
2007-09-06 Added SYNONYM endothelium-derived relaxation factor-forming enzyme activity
2007-09-06 Added SYNONYM endothelium-derived relaxing factor synthase activity
2007-09-06 Added SYNONYM nitric-oxide synthetase activity
2007-08-09 Added SYNONYM nitric oxide synthase activity
2007-08-09 Deleted SYNONYM nitric oxide synthase activity
2006-01-26 Updated DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
2004-04-19 Added SYNONYM nitric oxide synthase activity
2004-04-16 Deleted SYNONYM nitric oxide synthase activity
2003-10-27 Added SYNONYM nitric oxide synthase activity
2003-10-27 Added XREF MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
2003-10-24 Updated DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP.
2003-09-13 Updated TERM nitric-oxide synthase activity
2003-03-19 Updated TERM nitric oxide synthase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + N NADP.
2002-02-06 Updated TERM nitric oxide synthase
2001-04-03 Updated TERM nitric oxide synthase
2001-03-30 Added XREF EC:1.14.13.39
2001-03-30 Added TERM nitric oxide synthase

Term

Timestamp Action Category Detail
2003-09-13 Updated TERM nitric-oxide synthase activity
2003-03-19 Updated TERM nitric oxide synthase activity
2002-02-06 Updated TERM nitric oxide synthase
2001-04-03 Updated TERM nitric oxide synthase
2001-03-30 Added TERM nitric oxide synthase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
2007-12-14 Added SYNONYM L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity
2007-12-14 Added SYNONYM nitric oxide synthetase activity
2007-09-06 Added SYNONYM NADPH-diaphorase activity
2007-09-06 Added SYNONYM NO synthase activity
2007-09-06 Added SYNONYM endothelium-derived relaxation factor-forming enzyme activity
2007-09-06 Added SYNONYM endothelium-derived relaxing factor synthase activity
2007-09-06 Added SYNONYM nitric-oxide synthetase activity
2007-08-09 Added SYNONYM nitric oxide synthase activity
2007-08-09 Deleted SYNONYM nitric oxide synthase activity
2006-01-26 Updated DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
2004-04-19 Added SYNONYM nitric oxide synthase activity
2004-04-16 Deleted SYNONYM nitric oxide synthase activity
2003-10-27 Added SYNONYM nitric oxide synthase activity
2003-10-24 Updated DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP.
2002-11-27 Added DEFINITION Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + N NADP.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:24668
2003-10-27 Added XREF MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
2001-03-30 Added XREF EC:1.14.13.39
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