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GO:0004508 steroid 17-alpha-monooxygenase activity

Term Information

ID GO:0004508
Name steroid 17-alpha-monooxygenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
GONUTS GO:0004508 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact steroid 17alpha-hydroxylase activity
exact steroid 17alpha-monooxygenase activity
exact steroid 17alphahydroxylase/17,20 lyase activity
exact steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
narrow cytochrome p450 XVIIA1 activity
exact steroid 17-alpha-hydroxylase/17,20 lyase activity
narrow cytochrome P450 CYP17
exact steroid 17-alpha-hydroxylase activity
exact 17alpha-hydroxylase-C17,20 lyase activity
related cytochrome P-450 (P-45017alpha,lyase)
related cytochrome P45017alpha
exact steroid 17-alpha-hydroxylase-C17-20 lyase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.14.99.9
MetaCyc STEROID-17-ALPHA-MONOOXYGENASE-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004508:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004508. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004508 based on the entire annotation set Co-occurrence statistics for GO:0004508 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2007-11-08 Added SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2007-11-08 Added SYNONYM cytochrome P-450 (P-45017alpha,lyase)
2007-11-08 Added SYNONYM cytochrome P45017alpha
2007-11-08 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase activity
2007-11-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2007-11-08 Added SYNONYM steroid 17alpha-monooxygenase activity
2007-11-08 Added SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2007-11-08 Added SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2007-11-08 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-09-06 Added SYNONYM cytochrome p450 XVIIA1 activity
2007-09-06 Added SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP17
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-08-09 Deleted SYNONYM cytochrome P450 CYP17
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2005-03-22 Updated DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2004-04-19 Added SYNONYM cytochrome P450 CYP17
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase activity
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2004-04-16 Deleted SYNONYM cytochrome P450 CYP17
2004-04-16 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-10-27 Added SYNONYM cytochrome P450 CYP17
2003-10-27 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-10-27 Added XREF MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
2003-08-22 Updated DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2003-08-21 Deleted SYNONYM cytochrome P450 CYP17
2003-08-21 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-03-19 Updated TERM steroid 17-alpha-monooxygenase activity
2003-03-19 Deleted SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
2002-12-06 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2002-11-27 Added DEFINITION Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.
2002-02-06 Updated TERM steroid 17-alpha-monooxygenase
2001-04-03 Updated TERM steroid 17-alpha-monooxygenase
2001-03-30 Added XREF EC:1.14.99.9
2001-03-30 Added SYNONYM cytochrome P450 CYP17
2001-03-30 Added SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
2001-03-30 Added TERM steroid 17-alpha-monooxygenase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM steroid 17-alpha-monooxygenase activity
2002-02-06 Updated TERM steroid 17-alpha-monooxygenase
2001-04-03 Updated TERM steroid 17-alpha-monooxygenase
2001-03-30 Added TERM steroid 17-alpha-monooxygenase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2007-11-08 Added SYNONYM 17alpha-hydroxylase-C17,20 lyase activity
2007-11-08 Added SYNONYM cytochrome P-450 (P-45017alpha,lyase)
2007-11-08 Added SYNONYM cytochrome P45017alpha
2007-11-08 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase activity
2007-11-08 Added SYNONYM steroid 17alpha-hydroxylase activity
2007-11-08 Added SYNONYM steroid 17alpha-monooxygenase activity
2007-11-08 Added SYNONYM steroid 17alphahydroxylase/17,20 lyase activity
2007-11-08 Added SYNONYM steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
2007-11-08 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-09-06 Added SYNONYM cytochrome p450 XVIIA1 activity
2007-09-06 Added SYNONYM steroid 17-alpha-hydroxylase/17,20 lyase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP17
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2007-08-09 Deleted SYNONYM cytochrome P450 CYP17
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase activity
2007-08-09 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2005-03-22 Updated DEFINITION Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
2004-04-19 Added SYNONYM cytochrome P450 CYP17
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase activity
2004-04-19 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2004-04-16 Deleted SYNONYM cytochrome P450 CYP17
2004-04-16 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-10-27 Added SYNONYM cytochrome P450 CYP17
2003-10-27 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-08-22 Updated DEFINITION Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O.
2003-08-21 Deleted SYNONYM cytochrome P450 CYP17
2003-08-21 Deleted SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2003-03-19 Deleted SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase
2002-12-06 Added SYNONYM steroid 17-alpha-hydroxylase-C17-20 lyase
2002-11-27 Added DEFINITION Catalysis of the reaction: arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.
2001-03-30 Added SYNONYM cytochrome P450 CYP17
2001-03-30 Added SYNONYM steroid 17-alpha-hydroxylase/C17-20 lyase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.99.9
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