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GO:0004506 squalene monooxygenase activity

Term Information

ID GO:0004506
Name squalene monooxygenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
GONUTS GO:0004506 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
exact squalene epoxidase activity
exact squalene 2,3-oxidocyclase activity
exact squalene oxydocyclase activity
exact squalene-2,3-epoxidase activity
exact squalene-2,3-epoxide cyclase activity
exact squalene hydroxylase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.14.13.132
InterPro IPR013698
KEGG R02874
MetaCyc SQUALENE-MONOOXYGENASE-RXN
RHEA 25285

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004506:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004506. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004506 based on the entire annotation set Co-occurrence statistics for GO:0004506 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-10-29 Deleted RELATION is a GO:0004497 (monooxygenase activity)
2012-03-01 Deleted DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2012-03-01 Added DEFINITION Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
2012-03-01 Added SYNONYM squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
2012-03-01 Deleted SYNONYM squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
2012-03-01 Added XREF KEGG:R02874
2012-03-01 Added XREF RHEA:25285
2012-03-01 Added XREF EC:1.14.13.132
2012-03-01 Deleted XREF RHEA:21943
2012-03-01 Deleted XREF EC:1.14.99.7
2012-03-01 Added RELATION is a GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
2012-03-01 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2011-09-16 Added XREF RHEA:21943
2008-05-13 Added DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2008-05-12 Deleted DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2008-04-01 Updated RELATION is a GO:0004497 (monooxygenase activity)
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2007-11-08 Added SYNONYM squalene 2,3-oxidocyclase activity
2007-11-08 Added SYNONYM squalene oxydocyclase activity
2007-11-08 Added SYNONYM squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
2007-11-08 Added SYNONYM squalene-2,3-epoxidase activity
2007-11-08 Added SYNONYM squalene-2,3-epoxide cyclase activity
2007-09-06 Added SYNONYM squalene epoxidase activity
2007-08-09 Added SYNONYM squalene hydroxylase activity
2007-08-09 Deleted SYNONYM squalene hydroxylase activity
2004-04-19 Added SYNONYM squalene hydroxylase activity
2003-10-27 Added XREF MetaCyc:SQUALENE-MONOOXYGENASE-RXN
2003-03-19 Updated TERM squalene monooxygenase activity
2002-11-27 Updated DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2002-02-06 Updated TERM squalene monooxygenase
2001-08-06 Added DEFINITION Enzyme that catalyzes the formation of a 2,3-epoxide in squalene.
2001-04-03 Updated TERM squalene monooxygenase
2001-03-30 Added XREF EC:1.14.99.7
2001-03-30 Added TERM squalene monooxygenase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM squalene monooxygenase activity
2002-02-06 Updated TERM squalene monooxygenase
2001-04-03 Updated TERM squalene monooxygenase
2001-03-30 Added TERM squalene monooxygenase

Definition/synonyms

Timestamp Action Category Detail
2012-03-01 Deleted DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2012-03-01 Added DEFINITION Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+).
2012-03-01 Added SYNONYM squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity
2012-03-01 Deleted SYNONYM squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
2008-05-13 Added DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2008-05-12 Deleted DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2007-11-08 Added SYNONYM squalene 2,3-oxidocyclase activity
2007-11-08 Added SYNONYM squalene oxydocyclase activity
2007-11-08 Added SYNONYM squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
2007-11-08 Added SYNONYM squalene-2,3-epoxidase activity
2007-11-08 Added SYNONYM squalene-2,3-epoxide cyclase activity
2007-09-06 Added SYNONYM squalene epoxidase activity
2007-08-09 Added SYNONYM squalene hydroxylase activity
2007-08-09 Deleted SYNONYM squalene hydroxylase activity
2004-04-19 Added SYNONYM squalene hydroxylase activity
2002-11-27 Updated DEFINITION Catalysis of the formation of a 2,3-epoxide in squalene.
2001-08-06 Added DEFINITION Enzyme that catalyzes the formation of a 2,3-epoxide in squalene.

Relationships

Timestamp Action Category Detail
2012-10-29 Deleted RELATION is a GO:0004497 (monooxygenase activity)
2012-03-01 Added RELATION is a GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
2012-03-01 Deleted RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0004497 (monooxygenase activity)
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)

Cross-references

Timestamp Action Category Detail
2012-03-01 Added XREF KEGG:R02874
2012-03-01 Added XREF RHEA:25285
2012-03-01 Added XREF EC:1.14.13.132
2012-03-01 Deleted XREF RHEA:21943
2012-03-01 Deleted XREF EC:1.14.99.7
2011-09-16 Added XREF RHEA:21943
2003-10-27 Added XREF MetaCyc:SQUALENE-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.99.7
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