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GO:0004498 calcidiol 1-monooxygenase activity

Term Information

ID GO:0004498
Name calcidiol 1-monooxygenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
GONUTS GO:0004498 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact 25-hydroxycholecalciferol 1-hydroxylase activity
exact calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
exact 25-hydroxyvitamin D3 1alpha-hydroxylase activity
exact 25-hydroxycholecalciferol 1alpha-hydroxylase activity
exact 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
exact 25-hydroxy D3-1alpha-hydroxylase activity
exact 25-hydroxyvitamin D-1 alpha hydroxylase activity
exact 25-hydroxycholecalciferol-1-hydroxylase activity
exact 25-hydroxycholecalciferol 1-monooxygenase activity
exact 25-OHD-1 alpha-hydroxylase activity
narrow cytochrome P450 CYP27B
related 1-hydroxylase-25-hydroxyvitamin D3 activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.14.13.13
KEGG R03610
MetaCyc CALCIDIOL-1-MONOOXYGENASE-RXN
RHEA 20576

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004498:
Relationship To GO:0004498 Child Term Child Term Name
Negatively regulates GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
Regulates GO:0060558 regulation of calcidiol 1-monooxygenase activity
Positively regulates GO:0060559 positive regulation of calcidiol 1-monooxygenase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004498. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004498 based on the entire annotation set Co-occurrence statistics for GO:0004498 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-05-17 Added RELATION part of GO:0036378 (calcitriol biosynthetic process from calciol)
2011-10-28 Added SYNONYM 1-hydroxylase-25-hydroxyvitamin D3 activity
2011-10-28 Deleted SYNONYM 1-hydroxylase-25-hydroxyvitamin D3
2010-10-11 Added DEFINITION Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2010-10-11 Added XREF KEGG:R03610
2010-10-11 Added XREF RHEA:20576
2008-05-13 Added DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2008-04-01 Updated RELATION is a GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
2007-11-08 Added SYNONYM 1-hydroxylase-25-hydroxyvitamin D3
2007-11-08 Added SYNONYM 25-hydroxy D3-1alpha-hydroxylase activity
2007-11-08 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
2007-11-08 Added SYNONYM 25-hydroxycholecalciferol 1alpha-hydroxylase activity
2007-11-08 Added SYNONYM 25-hydroxyvitamin D3 1alpha-hydroxylase activity
2007-11-08 Added SYNONYM calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
2007-11-08 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2007-09-06 Added SYNONYM 25-OHD-1 alpha-hydroxylase activity
2007-09-06 Added SYNONYM 25-hydroxycholecalciferol 1-monooxygenase activity
2007-09-06 Added SYNONYM 25-hydroxycholecalciferol-1-hydroxylase activity
2007-09-06 Added SYNONYM 25-hydroxyvitamin D-1 alpha hydroxylase activity
2007-08-09 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2007-08-09 Added SYNONYM 25-hydroxycholecalciferol 1-hydroxylase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP27B
2007-08-09 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2007-08-09 Deleted SYNONYM 25-hydroxycholecalciferol 1-hydroxylase activity
2007-08-09 Deleted SYNONYM cytochrome P450 CYP27B
2004-04-19 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2004-04-19 Added SYNONYM 25-hydroxycholecalciferol 1-hydroxylase activity
2004-04-19 Added SYNONYM cytochrome P450 CYP27B
2004-04-16 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2004-04-16 Deleted SYNONYM cytochrome P450 CYP27B
2003-10-27 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2003-10-27 Added SYNONYM cytochrome P450 CYP27B
2003-10-27 Added XREF MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
2003-08-21 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2003-08-21 Deleted SYNONYM cytochrome P450 CYP27B
2003-03-19 Updated TERM calcidiol 1-monooxygenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2002-02-06 Updated TERM calcidiol 1-monooxygenase
2001-04-03 Updated TERM calcidiol 1-monooxygenase
2001-03-30 Added XREF EC:1.14.13.13
2001-03-30 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2001-03-30 Added SYNONYM cytochrome P450 CYP27B
2001-03-30 Added TERM calcidiol 1-monooxygenase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM calcidiol 1-monooxygenase activity
2002-02-06 Updated TERM calcidiol 1-monooxygenase
2001-04-03 Updated TERM calcidiol 1-monooxygenase
2001-03-30 Added TERM calcidiol 1-monooxygenase

Definition/synonyms

Timestamp Action Category Detail
2011-10-28 Added SYNONYM 1-hydroxylase-25-hydroxyvitamin D3 activity
2011-10-28 Deleted SYNONYM 1-hydroxylase-25-hydroxyvitamin D3
2010-10-11 Added DEFINITION Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2008-05-13 Added DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2007-11-08 Added SYNONYM 1-hydroxylase-25-hydroxyvitamin D3
2007-11-08 Added SYNONYM 25-hydroxy D3-1alpha-hydroxylase activity
2007-11-08 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase activity
2007-11-08 Added SYNONYM 25-hydroxycholecalciferol 1alpha-hydroxylase activity
2007-11-08 Added SYNONYM 25-hydroxyvitamin D3 1alpha-hydroxylase activity
2007-11-08 Added SYNONYM calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
2007-11-08 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2007-09-06 Added SYNONYM 25-OHD-1 alpha-hydroxylase activity
2007-09-06 Added SYNONYM 25-hydroxycholecalciferol 1-monooxygenase activity
2007-09-06 Added SYNONYM 25-hydroxycholecalciferol-1-hydroxylase activity
2007-09-06 Added SYNONYM 25-hydroxyvitamin D-1 alpha hydroxylase activity
2007-08-09 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2007-08-09 Added SYNONYM 25-hydroxycholecalciferol 1-hydroxylase activity
2007-08-09 Added SYNONYM cytochrome P450 CYP27B
2007-08-09 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2007-08-09 Deleted SYNONYM 25-hydroxycholecalciferol 1-hydroxylase activity
2007-08-09 Deleted SYNONYM cytochrome P450 CYP27B
2004-04-19 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2004-04-19 Added SYNONYM 25-hydroxycholecalciferol 1-hydroxylase activity
2004-04-19 Added SYNONYM cytochrome P450 CYP27B
2004-04-16 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2004-04-16 Deleted SYNONYM cytochrome P450 CYP27B
2003-10-27 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2003-10-27 Added SYNONYM cytochrome P450 CYP27B
2003-08-21 Deleted SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2003-08-21 Deleted SYNONYM cytochrome P450 CYP27B
2002-11-27 Added DEFINITION Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.
2001-03-30 Added SYNONYM 25-hydroxy vitamin D3 1-alpha-hydroxylase
2001-03-30 Added SYNONYM cytochrome P450 CYP27B

Relationships

Timestamp Action Category Detail
2013-05-17 Added RELATION part of GO:0036378 (calcitriol biosynthetic process from calciol)
2008-04-01 Updated RELATION is a GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF KEGG:R03610
2010-10-11 Added XREF RHEA:20576
2003-10-27 Added XREF MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
2001-03-30 Added XREF EC:1.14.13.13
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