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GO:0004497 monooxygenase activity

Term Information

ID GO:0004497
Name monooxygenase activity
Ontology Molecular Function
Definition Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
GONUTS GO:0004497 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related hydroxylase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_pir462

Cross-references

Database ID
InterPro IPR000323
InterPro IPR000689
InterPro IPR001273
InterPro IPR002103
InterPro IPR002397
InterPro IPR002399
InterPro IPR002402
InterPro IPR002403
InterPro IPR003454
InterPro IPR008068
InterPro IPR016215
InterPro IPR018301
InterPro IPR019914
InterPro IPR020469
UniProtKB-KW Monooxygenase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004497:
Relationship To GO:0004497 Child Term Child Term Name
Is a GO:0018690 4-methoxybenzoate monooxygenase (O-demethylating) activity
Is a GO:0019135 deoxyhypusine monooxygenase activity
Is a GO:0047096 androst-4-ene-3,17-dione monooxygenase activity
Is a GO:0047097 phylloquinone monooxygenase (2,3-epoxidizing) activity
Is a GO:0047546 2-hydroxypyridine 5-monooxygenase activity
Is a GO:0047563 3-hydroxybenzoate 2-monooxygenase activity
Is a GO:0047882 estradiol 6-beta-monooxygenase activity
Is a GO:0050056 linalool 8-monooxygenase activity
Is a GO:0050212 progesterone 11-alpha-monooxygenase activity
Is a GO:0050214 progesterone monooxygenase activity
Is a GO:0050292 steroid 9-alpha-monooxygenase activity
Is a GO:0050603 thiophene-2-carbonyl-CoA monooxygenase activity
Is a GO:0045289 luciferin monooxygenase activity
Is a GO:0018591 methyl tertiary butyl ether 3-monooxygenase activity
Is a GO:0018592 4-nitrocatechol 4-monooxygenase activity
Is a GO:0018593 4-chlorophenoxyacetate monooxygenase activity
Is a GO:0018594 tert-butanol 2-monooxygenase activity
Is a GO:0018595 alpha-pinene monooxygenase activity
Is a GO:0018597 ammonia monooxygenase activity
Is a GO:0018599 2-hydroxyisobutyrate 3-monooxygenase activity
Is a GO:0018679 dibenzothiophene-5,5-dioxide monooxygenase activity
Is a GO:0031172 ornithine N5-monooxygenase activity
Is a GO:0018529 nitrilotriacetate monooxygenase activity
Is a GO:0008389 coumarin 7-hydroxylase activity
Is a GO:0008391 arachidonic acid monooxygenase activity
Is a GO:0008395 steroid hydroxylase activity
Is a GO:0008399 naphthalene hydroxylase activity
Is a GO:0008401 retinoic acid 4-hydroxylase activity
Is a GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity
Is a GO:0046409 p-coumarate 3-hydroxylase activity
Is a GO:0046424 ferulate 5-hydroxylase activity
Is a GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
Is a GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Is a GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Is a GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
Is a GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Is a GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
Is a GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
Is a GO:0097259 20-aldehyde-leukotriene B4 20-monooxygenase activity
Regulates GO:0032768 regulation of monooxygenase activity
Negatively regulates GO:0032769 negative regulation of monooxygenase activity
Positively regulates GO:0032770 positive regulation of monooxygenase activity
Is a GO:0052694 jasmonoyl-isoleucine-12-hydroxylase activity
Is a GO:0052608 echinenone 3-hydroxylase activity
Is a GO:0052609 4-ketotorulene 3-hydroxylase activity
Is a GO:0052610 beta-cryptoxanthin hydroxylase activity
Is a GO:0052611 beta-carotene 3-hydroxylase activity
Is a GO:0052612 adonirubin 3-hydroxylase activity
Is a GO:0052613 canthaxanthin 3-hydroxylase activity
Is a GO:0010291 carotene beta-ring hydroxylase activity
Is a GO:0072374 carotene epsilon hydroxylase activity
Is a GO:0080014 thalianol hydroxylase activity
Is a GO:0071614 linoleic acid epoxygenase activity
Is a GO:0052722 fatty acid in-chain hydroxylase activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004497. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004497 based on the entire annotation set Co-occurrence statistics for GO:0004497 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2009-12-06 Added SYNONYM hydroxylase activity
2008-06-09 Added SLIM goslim_pir
2008-05-13 Added DEFINITION Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2008-05-12 Deleted DEFINITION Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2008-04-01 Updated RELATION is a GO:0016491 (oxidoreductase activity)
2004-11-09 Updated DEFINITION Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2004-11-09 Deleted SYNONYM unspecific monooxygenase activity
2004-11-09 Deleted XREF MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
2004-11-09 Deleted XREF EC:1.14.14.1
2004-11-09 Deleted SECONDARY GO:0050381 (unspecific monooxygenase activity)
2004-08-20 Updated DEFINITION Catalysis of the incorporation of only one atom of oxygen from dioxygen (O2) into the donor.
2004-04-16 Added SYNONYM unspecific monooxygenase activity
2004-04-16 Added SECONDARY GO:0050381 (unspecific monooxygenase activity)
2004-04-16 Added XREF MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
2004-04-16 Added XREF EC:1.14.14.1
2003-10-23 Updated DEFINITION Catalysis of the incorporation by an oxidoreductase of only one atom of oxygen from dioxygen (O2) into the donor.
2003-08-05 Updated DEFINITION Catalysis of the incorporation by an oxidoreductase of only one atom of oxygen from dioxygen into the donor.
2003-03-19 Updated TERM monooxygenase activity
2002-11-27 Added DEFINITION Catalysis by an oxidoreductase of the incorporation of only one atom of oxygen from dioxygen into the donor.
2002-02-06 Updated TERM monooxygenase
2001-04-03 Updated TERM monooxygenase
2001-03-30 Added TERM monooxygenase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM monooxygenase activity
2002-02-06 Updated TERM monooxygenase
2001-04-03 Updated TERM monooxygenase
2001-03-30 Added TERM monooxygenase

Definition/synonyms

Timestamp Action Category Detail
2009-12-06 Added SYNONYM hydroxylase activity
2008-05-13 Added DEFINITION Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2008-05-12 Deleted DEFINITION Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2004-11-09 Updated DEFINITION Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
2004-11-09 Deleted SYNONYM unspecific monooxygenase activity
2004-08-20 Updated DEFINITION Catalysis of the incorporation of only one atom of oxygen from dioxygen (O2) into the donor.
2004-04-16 Added SYNONYM unspecific monooxygenase activity
2003-10-23 Updated DEFINITION Catalysis of the incorporation by an oxidoreductase of only one atom of oxygen from dioxygen (O2) into the donor.
2003-08-05 Updated DEFINITION Catalysis of the incorporation by an oxidoreductase of only one atom of oxygen from dioxygen into the donor.
2002-11-27 Added DEFINITION Catalysis by an oxidoreductase of the incorporation of only one atom of oxygen from dioxygen into the donor.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016491 (oxidoreductase activity)

Cross-references

Timestamp Action Category Detail
2004-11-09 Deleted XREF MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
2004-11-09 Deleted XREF EC:1.14.14.1
2004-04-16 Added XREF MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
2004-04-16 Added XREF EC:1.14.14.1

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_pir
2008-06-09 Added SLIM goslim_pir
2004-11-09 Deleted SECONDARY GO:0050381 (unspecific monooxygenase activity)
2004-04-16 Added SECONDARY GO:0050381 (unspecific monooxygenase activity)
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