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GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity

Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.

Term Information

ID GO:0004489
Name methylenetetrahydrofolate reductase (NADPH) activity
Ontology Molecular Function
Definition Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
Comment Includes EC 1.7.99.5.

Synonyms

Type Synonym
exact 5,10-methylenetetrahydrofolate reductase (FADH2) activity
broad N(5,10)-methylenetetrahydrofolate reductase activity
exact 5,10-CH2-H4folate reductase activity
exact 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
exact 5-methyltetrahydrofolate:NAD+ oxidoreductase activity
exact 5-methyltetrahydrofolate:NADP+ oxidoreductase activity
related MetF
exact N5,10-methylenetetrahydrofolate reductase activity
exact N5,N10-methylenetetrahydrofolate reductase activity
exact methylenetetrahydrofolate reductase (NADPH2)
related methylenetetrahydrofolate reductase [NAD(P)H]
broad N(5),N(10)-methylenetetrahydrofolate reductase activity
broad MTHFR activity
exact 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
exact 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
exact 5-methyltetrahydrofolate:NAD oxidoreductase activity
exact 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
exact 5,10-methylenetetrahydropteroylglutamate reductase activity
broad 5,10-methylenetetrahydrofolic acid reductase activity
broad 5,10-methylenetetrahydrofolate reductase activity
exact 5,10-methylenetetrahydrofolate reductase (NADPH) activity
related 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
exact 5,10-CH(2)-H(4)folate reductase activity
related 1.7.99.5
exact 5,10-methylenetetrahydrofolate reductase (FADH) activity
broad methylenetetrahydrofolic acid reductase activity
broad methylenetetrahydrofolate reductase activity
exact methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
related methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
exact methylenetetrahydrofolate reductase (NADPH(2)) activity

Cross-references associated with this term:

Database ID
INTERPRO IPR003171
MetaCyc 1.5.1.20-RXN
EC 1.5.1.20
INTERPRO IPR004621

This term can be used instead of these obsolete terms:

GO:0006133 5,10-methylenetetrahydrofolate oxidation (consider GO:0004489)

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Ancestor Chart

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Co-occurring Terms

Co-occurrence statistics

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