GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity
Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
Term Information
GO:0004489
methylenetetrahydrofolate reductase (NADPH) activity
Molecular Function
Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.
Includes EC 1.7.99.5.
Type
Synonym
exact
5,10-methylenetetrahydrofolate reductase (FADH2) activity
broad
N(5,10)-methylenetetrahydrofolate reductase activity
exact
5,10-CH2-H4folate reductase activity
exact
5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity
exact
5-methyltetrahydrofolate:NAD+ oxidoreductase activity
exact
5-methyltetrahydrofolate:NADP+ oxidoreductase activity
related
MetF
exact
N5,10-methylenetetrahydrofolate reductase activity
exact
N5,N10-methylenetetrahydrofolate reductase activity
exact
methylenetetrahydrofolate reductase (NADPH2)
related
methylenetetrahydrofolate reductase [NAD(P)H]
broad
N(5),N(10)-methylenetetrahydrofolate reductase activity
broad
MTHFR activity
exact
5-methyltetrahydrofolate:NADP(+) oxidoreductase activity
exact
5-methyltetrahydrofolate:NAD(+) oxidoreductase activity
exact
5-methyltetrahydrofolate:NAD oxidoreductase activity
exact
5-methyltetrahydrofolate:(acceptor) oxidoreductase activity
exact
5,10-methylenetetrahydropteroylglutamate reductase activity
broad
5,10-methylenetetrahydrofolic acid reductase activity
broad
5,10-methylenetetrahydrofolate reductase activity
exact
5,10-methylenetetrahydrofolate reductase (NADPH) activity
related
5,10-methylenetetrahydrofolate reductase (FADH(2)) activity
exact
5,10-CH(2)-H(4)folate reductase activity
related
1.7.99.5
exact
5,10-methylenetetrahydrofolate reductase (FADH) activity
broad
methylenetetrahydrofolic acid reductase activity
broad
methylenetetrahydrofolate reductase activity
exact
methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity
related
methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity
exact
methylenetetrahydrofolate reductase (NADPH(2)) activity
Cross-references associated with this term:
Database
ID
INTERPRO
IPR003171
MetaCyc
1.5.1.20-RXN
EC
1.5.1.20
INTERPRO
IPR004621
This term can be used instead of these obsolete terms:
GO:0006133 5,10-methylenetetrahydrofolate oxidation
(consider GO:0004489)
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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity
Relationship key
Code
p art of
i s a
r egulates
+ ve regulates
- ve regulates
Child Terms
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Protein Annotation
Co-occurring Terms
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