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GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity

Term Information

ID GO:0004473
Name malate dehydrogenase (decarboxylating) (NADP+) activity
Ontology Molecular Function
Definition Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
Comment For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
GONUTS GO:0004473 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related 'malic' enzyme
exact malate dehydrogenase (decarboxylating, NADP)
exact L-malate:NADP oxidoreductase activity
exact (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
exact malate dehydrogenase (NADP, decarboxylating)
related NADP-specific malic enzyme
exact NADP-specific malate dehydrogenase activity
related NADP-linked decarboxylating malic enzyme
exact NADP-malic enzyme activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.40
InterPro IPR012188
KEGG R00216
MetaCyc MALIC-NADP-RXN
RHEA 18256

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004473:
Relationship To GO:0004473 Child Term Child Term Name
Regulates GO:1903218 regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
Negatively regulates GO:1903219 negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity
Positively regulates GO:1903220 positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004473. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004473 based on the entire annotation set Co-occurrence statistics for GO:0004473 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-23 Updated TERM malate dehydrogenase (decarboxylating) (NADP+) activity
2013-10-23 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2013-10-23 Added DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
2013-10-23 Added XREF KEGG:R00216
2011-09-16 Added XREF RHEA:18256
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0004470 (malic enzyme activity)
2007-11-08 Added SYNONYM 'malic' enzyme
2007-11-08 Added SYNONYM (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
2007-11-08 Added SYNONYM L-malate:NADP oxidoreductase activity
2007-11-08 Added SYNONYM NADP-linked decarboxylating malic enzyme
2007-11-08 Added SYNONYM NADP-specific malate dehydrogenase activity
2007-11-08 Added SYNONYM NADP-specific malic enzyme
2007-11-08 Added SYNONYM malate dehydrogenase (NADP, decarboxylating)
2007-11-08 Added SYNONYM malate dehydrogenase (decarboxylating, NADP)
2007-09-06 Added SYNONYM NADP-malic enzyme activity
2004-01-07 Updated TERM malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
2003-10-27 Added XREF MetaCyc:MALIC-NADP-RXN
2003-09-09 Updated TERM malate dehydrogenase (oxaloacetate-decarboxylating) (NADP) activity
2003-09-06 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP) activity
2003-03-19 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2002-02-06 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)
2001-08-06 Added DEFINITION Catalysis of a reaction between malate and NADP to produce pyruvate and NADPH.
2001-04-03 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)
2001-03-30 Added XREF EC:1.1.1.40
2001-03-30 Added TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)

Term

Timestamp Action Category Detail
2013-10-23 Updated TERM malate dehydrogenase (decarboxylating) (NADP+) activity
2004-01-07 Updated TERM malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
2003-09-09 Updated TERM malate dehydrogenase (oxaloacetate-decarboxylating) (NADP) activity
2003-09-06 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP) activity
2003-03-19 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) activity
2002-02-06 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)
2001-04-03 Updated TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)
2001-03-30 Added TERM malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)

Definition/synonyms

Timestamp Action Category Detail
2013-10-23 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2013-10-23 Added DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2007-11-08 Added SYNONYM 'malic' enzyme
2007-11-08 Added SYNONYM (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
2007-11-08 Added SYNONYM L-malate:NADP oxidoreductase activity
2007-11-08 Added SYNONYM NADP-linked decarboxylating malic enzyme
2007-11-08 Added SYNONYM NADP-specific malate dehydrogenase activity
2007-11-08 Added SYNONYM NADP-specific malic enzyme
2007-11-08 Added SYNONYM malate dehydrogenase (NADP, decarboxylating)
2007-11-08 Added SYNONYM malate dehydrogenase (decarboxylating, NADP)
2007-09-06 Added SYNONYM NADP-malic enzyme activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.
2001-08-06 Added DEFINITION Catalysis of a reaction between malate and NADP to produce pyruvate and NADPH.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0004470 (malic enzyme activity)

Cross-references

Timestamp Action Category Detail
2013-10-23 Added XREF KEGG:R00216
2011-09-16 Added XREF RHEA:18256
2003-10-27 Added XREF MetaCyc:MALIC-NADP-RXN
2001-03-30 Added XREF EC:1.1.1.40
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