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GO:0004467 long-chain fatty acid-CoA ligase activity

Term Information

ID GO:0004467
Name long-chain fatty acid-CoA ligase activity
Ontology Molecular Function
Definition Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
GONUTS GO:0004467 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related long-chain fatty acid activation
exact long-chain-fatty-acyl-CoA synthetase activity
exact long-chain acyl-CoA synthetase activity
narrow pristanoyl-CoA synthetase
exact long-chain acyl-coenzyme A synthetase activity
narrow long-chain acyl-CoA synthetase II
narrow long-chain acyl-CoA synthetase I
exact long-chain acyl CoA synthetase activity
exact long chain fatty acyl-CoA synthetase activity
exact long-chain-fatty-acid-CoA ligase activity
narrow oleoyl-CoA synthetase
narrow palmitoyl coenzyme A synthetase
narrow palmitoyl-CoA ligase
narrow palmitoyl-CoA synthase
exact long-chain fatty acyl coenzyme A synthetase activity
narrow stearoyl-CoA synthetase
related thiokinase
exact acyl-CoA synthetase activity
broad acyl-activating enzyme activity
exact fatty acid thiokinase (long-chain) activity
exact lignoceroyl-CoA synthase activity
narrow ACS3
narrow FAA1
exact LCFA synthetase activity
narrow arachidonyl-CoA synthetase
exact fatty acid thiokinase (long chain) activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 6.2.1.3
MetaCyc ACYLCOASYN-RXN
MetaCyc PWY-5143
UM-BBD_enzymeID e0025

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004467:
Relationship To GO:0004467 Child Term Child Term Name
Is a GO:0090432 myristoyl-CoA ligase activity
Is a GO:0090433 palmitoyl-CoA ligase activity
Is a GO:0090434 oleoyl-CoA ligase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004467. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004467 based on the entire annotation set Co-occurrence statistics for GO:0004467 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-07-28 Added RELATION part of GO:0001676 (long-chain fatty acid metabolic process)
2012-06-20 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
2012-06-20 Deleted DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
2012-02-04 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
2012-02-04 Deleted DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2011-09-22 Deleted SYNONYM long-chain fatty acid-CoA ligase activity
2010-05-13 Updated TERM long-chain fatty acid-CoA ligase activity
2010-05-13 Added SYNONYM long-chain-fatty-acid-CoA ligase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2008-04-01 Updated RELATION is a GO:0015645 (fatty acid ligase activity)
2008-01-07 Added SYNONYM long-chain fatty acid-CoA ligase activity
2007-12-14 Added SYNONYM FAA1
2007-12-14 Added SYNONYM LCFA synthetase activity
2007-12-14 Added SYNONYM arachidonyl-CoA synthetase
2007-12-14 Added SYNONYM fatty acid thiokinase (long chain) activity
2007-12-14 Added SYNONYM ACS3
2007-12-14 Added SYNONYM long chain fatty acyl-CoA synthetase activity
2007-12-14 Added SYNONYM long-chain acyl CoA synthetase activity
2007-12-14 Added SYNONYM long-chain acyl-CoA synthetase I
2007-12-14 Added SYNONYM long-chain acyl-CoA synthetase II
2007-12-14 Added SYNONYM long-chain acyl-coenzyme A synthetase activity
2007-12-14 Added SYNONYM long-chain fatty acyl coenzyme A synthetase activity
2007-12-14 Added SYNONYM oleoyl-CoA synthetase
2007-12-14 Added SYNONYM palmitoyl coenzyme A synthetase
2007-12-14 Added SYNONYM palmitoyl-CoA ligase
2007-12-14 Added SYNONYM palmitoyl-CoA synthase
2007-12-14 Added SYNONYM pristanoyl-CoA synthetase
2007-12-14 Added SYNONYM stearoyl-CoA synthetase
2007-12-14 Added SYNONYM thiokinase
2007-11-08 Added SYNONYM long-chain acyl-CoA synthetase activity
2007-11-08 Added SYNONYM long-chain-fatty-acyl-CoA synthetase activity
2007-11-08 Deleted SYNONYM long-chain acyl-CoA synthetase
2007-11-08 Deleted SYNONYM long-chain-fatty-acyl-CoA synthetase
2007-09-06 Added SYNONYM acyl-CoA synthetase activity
2007-09-06 Added SYNONYM acyl-activating enzyme activity
2007-09-06 Added SYNONYM fatty acid thiokinase (long-chain) activity
2007-09-06 Added SYNONYM lignoceroyl-CoA synthase activity
2007-09-06 Deleted SYNONYM acyl-CoA synthetase
2007-08-09 Added SYNONYM acyl-CoA synthetase
2007-08-09 Added SYNONYM long-chain acyl-CoA synthetase
2007-08-09 Added SYNONYM long-chain fatty acid activation
2007-08-09 Added SYNONYM long-chain-fatty-acyl-CoA synthetase
2007-08-09 Deleted SYNONYM acyl-CoA synthetase
2007-08-09 Deleted SYNONYM long-chain acyl-CoA synthetase
2007-08-09 Deleted SYNONYM long-chain fatty acid activation
2007-08-09 Deleted SYNONYM long-chain-fatty-acyl-CoA synthetase
2007-07-22 Added XREF MetaCyc:PWY-5143
2005-12-01 Added SYNONYM long-chain fatty acid activation
2005-11-29 Updated DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2004-04-19 Added SYNONYM acyl-CoA synthetase
2004-04-19 Added SYNONYM long-chain acyl-CoA synthetase
2004-04-19 Added SYNONYM long-chain-fatty-acyl-CoA synthetase
2004-04-16 Deleted SYNONYM acyl-CoA synthetase
2004-04-16 Deleted SYNONYM long-chain acyl-CoA synthetase
2004-04-16 Deleted SYNONYM long-chain-fatty-acyl-CoA synthetase
2003-10-27 Added SYNONYM acyl-CoA synthetase
2003-10-27 Added SYNONYM long-chain acyl-CoA synthetase
2003-10-27 Added SYNONYM long-chain-fatty-acyl-CoA synthetase
2003-10-27 Added XREF UM-BBD_enzymeID:e0025
2003-10-27 Added XREF MetaCyc:ACYLCOASYN-RXN
2003-09-06 Updated TERM long-chain-fatty-acid-CoA ligase activity
2003-03-19 Updated TERM long-chain-fatty-acid-CoA-ligase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
2002-02-06 Updated TERM long-chain-fatty-acid-CoA-ligase
2001-04-03 Updated TERM long-chain-fatty-acid-CoA-ligase
2001-03-30 Added XREF EC:6.2.1.3
2001-03-30 Added TERM long-chain-fatty-acid-CoA-ligase

Term

Timestamp Action Category Detail
2010-05-13 Updated TERM long-chain fatty acid-CoA ligase activity
2003-09-06 Updated TERM long-chain-fatty-acid-CoA ligase activity
2003-03-19 Updated TERM long-chain-fatty-acid-CoA-ligase activity
2002-02-06 Updated TERM long-chain-fatty-acid-CoA-ligase
2001-04-03 Updated TERM long-chain-fatty-acid-CoA-ligase
2001-03-30 Added TERM long-chain-fatty-acid-CoA-ligase

Definition/synonyms

Timestamp Action Category Detail
2012-06-20 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
2012-06-20 Deleted DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
2012-02-04 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
2012-02-04 Deleted DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2011-09-22 Deleted SYNONYM long-chain fatty acid-CoA ligase activity
2010-05-13 Added SYNONYM long-chain-fatty-acid-CoA ligase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2008-01-07 Added SYNONYM long-chain fatty acid-CoA ligase activity
2007-12-14 Added SYNONYM FAA1
2007-12-14 Added SYNONYM LCFA synthetase activity
2007-12-14 Added SYNONYM arachidonyl-CoA synthetase
2007-12-14 Added SYNONYM fatty acid thiokinase (long chain) activity
2007-12-14 Added SYNONYM ACS3
2007-12-14 Added SYNONYM long chain fatty acyl-CoA synthetase activity
2007-12-14 Added SYNONYM long-chain acyl CoA synthetase activity
2007-12-14 Added SYNONYM long-chain acyl-CoA synthetase I
2007-12-14 Added SYNONYM long-chain acyl-CoA synthetase II
2007-12-14 Added SYNONYM long-chain acyl-coenzyme A synthetase activity
2007-12-14 Added SYNONYM long-chain fatty acyl coenzyme A synthetase activity
2007-12-14 Added SYNONYM oleoyl-CoA synthetase
2007-12-14 Added SYNONYM palmitoyl coenzyme A synthetase
2007-12-14 Added SYNONYM palmitoyl-CoA ligase
2007-12-14 Added SYNONYM palmitoyl-CoA synthase
2007-12-14 Added SYNONYM pristanoyl-CoA synthetase
2007-12-14 Added SYNONYM stearoyl-CoA synthetase
2007-12-14 Added SYNONYM thiokinase
2007-11-08 Added SYNONYM long-chain acyl-CoA synthetase activity
2007-11-08 Added SYNONYM long-chain-fatty-acyl-CoA synthetase activity
2007-11-08 Deleted SYNONYM long-chain acyl-CoA synthetase
2007-11-08 Deleted SYNONYM long-chain-fatty-acyl-CoA synthetase
2007-09-06 Added SYNONYM acyl-CoA synthetase activity
2007-09-06 Added SYNONYM acyl-activating enzyme activity
2007-09-06 Added SYNONYM fatty acid thiokinase (long-chain) activity
2007-09-06 Added SYNONYM lignoceroyl-CoA synthase activity
2007-09-06 Deleted SYNONYM acyl-CoA synthetase
2007-08-09 Added SYNONYM acyl-CoA synthetase
2007-08-09 Added SYNONYM long-chain acyl-CoA synthetase
2007-08-09 Added SYNONYM long-chain fatty acid activation
2007-08-09 Added SYNONYM long-chain-fatty-acyl-CoA synthetase
2007-08-09 Deleted SYNONYM acyl-CoA synthetase
2007-08-09 Deleted SYNONYM long-chain acyl-CoA synthetase
2007-08-09 Deleted SYNONYM long-chain fatty acid activation
2007-08-09 Deleted SYNONYM long-chain-fatty-acyl-CoA synthetase
2005-12-01 Added SYNONYM long-chain fatty acid activation
2005-11-29 Updated DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
2004-04-19 Added SYNONYM acyl-CoA synthetase
2004-04-19 Added SYNONYM long-chain acyl-CoA synthetase
2004-04-19 Added SYNONYM long-chain-fatty-acyl-CoA synthetase
2004-04-16 Deleted SYNONYM acyl-CoA synthetase
2004-04-16 Deleted SYNONYM long-chain acyl-CoA synthetase
2004-04-16 Deleted SYNONYM long-chain-fatty-acyl-CoA synthetase
2003-10-27 Added SYNONYM acyl-CoA synthetase
2003-10-27 Added SYNONYM long-chain acyl-CoA synthetase
2003-10-27 Added SYNONYM long-chain-fatty-acyl-CoA synthetase
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.

Relationships

Timestamp Action Category Detail
2012-07-28 Added RELATION part of GO:0001676 (long-chain fatty acid metabolic process)
2008-04-01 Updated RELATION is a GO:0015645 (fatty acid ligase activity)

Cross-references

Timestamp Action Category Detail
2007-07-22 Added XREF MetaCyc:PWY-5143
2003-10-27 Added XREF UM-BBD_enzymeID:e0025
2003-10-27 Added XREF MetaCyc:ACYLCOASYN-RXN
2001-03-30 Added XREF EC:6.2.1.3
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