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GO:0004463 leukotriene-A4 hydrolase activity

Term Information

ID GO:0004463
Name leukotriene-A4 hydrolase activity
Ontology Molecular Function
Definition Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
GONUTS GO:0004463 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact LTA-4 hydrolase activity
exact (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
exact leukotriene A(4) hydrolase activity
exact LTA4 hydrolase activity
exact leukotriene A4 hydrolase activity
related LTA4H

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.3.2.6
InterPro IPR012777
KEGG R03057
MetaCyc LEUKOTRIENE-A4-HYDROLASE-RXN
RHEA 22327

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004463:
Relationship To GO:0004463 Child Term Child Term Name
Is a GO:0008908 isochorismatase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004463. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004463 based on the entire annotation set Co-occurrence statistics for GO:0004463 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2010-10-11 Added DEFINITION Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
2010-10-11 Added XREF RHEA:22327
2010-10-11 Added XREF KEGG:R03057
2008-05-13 Added DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2008-04-01 Updated RELATION is a GO:0016803 (ether hydrolase activity)
2008-04-01 Deleted SYNONYM leukotriene-A4 hydrolase activity
2007-11-08 Added SYNONYM LTA4H
2007-11-08 Added SYNONYM leukotriene A4 hydrolase activity
2007-11-08 Added SYNONYM (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
2007-11-08 Added SYNONYM LTA4 hydrolase activity
2007-10-01 Added SYNONYM leukotriene-A4 hydrolase activity
2007-09-26 Deleted SYNONYM leukotriene-A4 hydrolase activity
2007-09-06 Added SYNONYM LTA-4 hydrolase activity
2007-09-06 Added SYNONYM leukotriene A(4) hydrolase activity
2007-09-06 Added SYNONYM leukotriene-A4 hydrolase activity
2003-10-27 Added XREF MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN
2003-03-19 Updated TERM leukotriene-A4 hydrolase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2002-02-06 Updated TERM leukotriene-A4 hydrolase
2001-04-03 Updated TERM leukotriene-A4 hydrolase
2001-03-30 Added XREF EC:3.3.2.6
2001-03-30 Added TERM leukotriene-A4 hydrolase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM leukotriene-A4 hydrolase activity
2002-02-06 Updated TERM leukotriene-A4 hydrolase
2001-04-03 Updated TERM leukotriene-A4 hydrolase
2001-03-30 Added TERM leukotriene-A4 hydrolase

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2010-10-11 Added DEFINITION Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).
2008-05-13 Added DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
2008-04-01 Deleted SYNONYM leukotriene-A4 hydrolase activity
2007-11-08 Added SYNONYM LTA4H
2007-11-08 Added SYNONYM leukotriene A4 hydrolase activity
2007-11-08 Added SYNONYM (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
2007-11-08 Added SYNONYM LTA4 hydrolase activity
2007-10-01 Added SYNONYM leukotriene-A4 hydrolase activity
2007-09-26 Deleted SYNONYM leukotriene-A4 hydrolase activity
2007-09-06 Added SYNONYM LTA-4 hydrolase activity
2007-09-06 Added SYNONYM leukotriene A(4) hydrolase activity
2007-09-06 Added SYNONYM leukotriene-A4 hydrolase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016803 (ether hydrolase activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:22327
2010-10-11 Added XREF KEGG:R03057
2003-10-27 Added XREF MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN
2001-03-30 Added XREF EC:3.3.2.6
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