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GO:0004463 leukotriene-A4 hydrolase activity

Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.

Term Information

ID GO:0004463
Name leukotriene-A4 hydrolase activity
Ontology Molecular Function
Definition Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
Comment

Synonyms

Type Synonym
exact leukotriene A4 hydrolase activity
exact LTA-4 hydrolase activity
exact leukotriene A(4) hydrolase activity
exact (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity
exact LTA4 hydrolase activity
related LTA4H

Cross-references associated with this term:

Database ID
INTERPRO IPR012777
MetaCyc LEUKOTRIENE-A4-HYDROLASE-RXN
EC 3.3.2.6

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016801 hydrolase activity, acting on ether bonds
GO:0016803 ether hydrolase activity
GO:0004463 leukotriene-A4 hydrolase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0008908 isochorismatase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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