spacer

GO:0004449 isocitrate dehydrogenase (NAD+) activity

Term Information

ID GO:0004449
Name isocitrate dehydrogenase (NAD+) activity
Ontology Molecular Function
Definition Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
GONUTS GO:0004449 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact nicotinamide adenine dinucleotide isocitrate dehydrogenase activity
exact isocitrate dehydrogenase (NAD) activity
exact NAD-specific isocitrate dehydrogenase activity
exact NAD-linked isocitrate dehydrogenase activity
exact NAD isocitric dehydrogenase activity
exact NAD isocitrate dehydrogenase activity
exact NAD dependent isocitrate dehydrogenase activity
exact isocitrate:NAD+ oxidoreductase (decarboxylating)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.41
InterPro IPR004434
MetaCyc ISOCITRATE-DEHYDROGENASE-NAD+-RXN
RHEA 23635

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004449:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004449. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004449 based on the entire annotation set Co-occurrence statistics for GO:0004449 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:23635
2009-05-21 Deleted XREF MetaCyc:ISOCITRATE-DEHYDROGENASE-(NAD+)-RXN
2009-05-21 Added XREF MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
2008-04-01 Updated RELATION is a GO:0004448 (isocitrate dehydrogenase activity)
2007-11-08 Added SYNONYM isocitrate:NAD+ oxidoreductase (decarboxylating)
2007-09-06 Added SYNONYM NAD dependent isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM NAD isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM NAD isocitric dehydrogenase activity
2007-09-06 Added SYNONYM NAD-linked isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM NAD-specific isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM isocitrate dehydrogenase (NAD) activity
2007-09-06 Added SYNONYM nicotinamide adenine dinucleotide isocitrate dehydrogenase activity
2004-01-07 Updated TERM isocitrate dehydrogenase (NAD+) activity
2003-10-27 Added XREF MetaCyc:ISOCITRATE-DEHYDROGENASE-(NAD+)-RXN
2003-10-23 Updated DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
2003-09-06 Updated TERM isocitrate dehydrogenase (NAD) activity
2003-03-19 Updated TERM isocitrate dehydrogenase (NAD+) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + carbon dioxide + NADH + H+.
2002-02-06 Updated TERM isocitrate dehydrogenase (NAD+)
2001-04-03 Updated TERM isocitrate dehydrogenase (NAD+)
2001-03-30 Added XREF EC:1.1.1.41
2001-03-30 Added TERM isocitrate dehydrogenase (NAD+)

Term

Timestamp Action Category Detail
2004-01-07 Updated TERM isocitrate dehydrogenase (NAD+) activity
2003-09-06 Updated TERM isocitrate dehydrogenase (NAD) activity
2003-03-19 Updated TERM isocitrate dehydrogenase (NAD+) activity
2002-02-06 Updated TERM isocitrate dehydrogenase (NAD+)
2001-04-03 Updated TERM isocitrate dehydrogenase (NAD+)
2001-03-30 Added TERM isocitrate dehydrogenase (NAD+)

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
2007-11-08 Added SYNONYM isocitrate:NAD+ oxidoreductase (decarboxylating)
2007-09-06 Added SYNONYM NAD dependent isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM NAD isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM NAD isocitric dehydrogenase activity
2007-09-06 Added SYNONYM NAD-linked isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM NAD-specific isocitrate dehydrogenase activity
2007-09-06 Added SYNONYM isocitrate dehydrogenase (NAD) activity
2007-09-06 Added SYNONYM nicotinamide adenine dinucleotide isocitrate dehydrogenase activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.
2002-11-27 Added DEFINITION Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + carbon dioxide + NADH + H+.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004448 (isocitrate dehydrogenase activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:23635
2009-05-21 Deleted XREF MetaCyc:ISOCITRATE-DEHYDROGENASE-(NAD+)-RXN
2009-05-21 Added XREF MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN
2003-10-27 Added XREF MetaCyc:ISOCITRATE-DEHYDROGENASE-(NAD+)-RXN
2001-03-30 Added XREF EC:1.1.1.41
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms