spacer

GO:0004448 isocitrate dehydrogenase activity

Term Information

ID GO:0004448
Name isocitrate dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
GONUTS GO:0004448 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact beta-ketoglutaric-isocitric carboxylase activity
related IDP3
exact isocitric dehydrogenase activity
exact oxalosuccinate carboxylase activity
exact oxalosuccinate decarboxylase activity
exact oxalsuccinic decarboxylase activity
exact isocitric acid dehydrogenase activity
related IDP1
related IDP2
exact IDH activity
exact IDP activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.-
MetaCyc ISOCITDEH-RXN

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004448:
Relationship To GO:0004448 Child Term Child Term Name
Is a GO:0004449 isocitrate dehydrogenase (NAD+) activity
Is a GO:0004450 isocitrate dehydrogenase (NADP+) activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004448. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004448 based on the entire annotation set Co-occurrence statistics for GO:0004448 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:ISOCITDEH-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2007-11-26 Added SYNONYM IDP1
2007-11-26 Added SYNONYM IDP2
2007-11-26 Added SYNONYM IDP3
2007-09-06 Added SYNONYM oxalsuccinic decarboxylase activity
2007-09-06 Added SYNONYM IDH activity
2007-09-06 Added SYNONYM IDP activity
2007-09-06 Added SYNONYM beta-ketoglutaric-isocitric carboxylase activity
2007-09-06 Added SYNONYM isocitric acid dehydrogenase activity
2007-09-06 Added SYNONYM isocitric dehydrogenase activity
2007-09-06 Added SYNONYM oxalosuccinate carboxylase activity
2007-09-06 Added SYNONYM oxalosuccinate decarboxylase activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
2003-03-26 Added DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + carbon dioxide + reduced acceptor.
2003-03-19 Updated TERM isocitrate dehydrogenase activity
2002-02-06 Updated TERM isocitrate dehydrogenase
2001-04-03 Updated TERM isocitrate dehydrogenase
2001-03-30 Added XREF EC:1.1.1.-
2001-03-30 Added TERM isocitrate dehydrogenase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM isocitrate dehydrogenase activity
2002-02-06 Updated TERM isocitrate dehydrogenase
2001-04-03 Updated TERM isocitrate dehydrogenase
2001-03-30 Added TERM isocitrate dehydrogenase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
2007-11-26 Added SYNONYM IDP1
2007-11-26 Added SYNONYM IDP2
2007-11-26 Added SYNONYM IDP3
2007-09-06 Added SYNONYM oxalsuccinic decarboxylase activity
2007-09-06 Added SYNONYM IDH activity
2007-09-06 Added SYNONYM IDP activity
2007-09-06 Added SYNONYM beta-ketoglutaric-isocitric carboxylase activity
2007-09-06 Added SYNONYM isocitric acid dehydrogenase activity
2007-09-06 Added SYNONYM isocitric dehydrogenase activity
2007-09-06 Added SYNONYM oxalosuccinate carboxylase activity
2007-09-06 Added SYNONYM oxalosuccinate decarboxylase activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.
2003-03-26 Added DEFINITION Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + carbon dioxide + reduced acceptor.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:ISOCITDEH-RXN
2001-03-30 Added XREF EC:1.1.1.-
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
16ms