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GO:0004435 phosphoinositide phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Term Information

ID GO:0004435
Name phosphoinositide phospholipase C activity
Ontology Molecular Function
Definition Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Comment

Synonyms

Type Synonym
exact 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
related phosphatidylinositol-4,5-bisphosphate hydrolysis
exact 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
broad triphosphoinositide phosphodiesterase activity
exact phosphoinositidase C activity
exact phosphatidylinositol phospholipase C activity
broad monophosphatidylinositol phosphodiesterase activity
exact PI-PLC activity
exact 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR016279
INTERPRO IPR001192
EC 3.1.4.11
MetaCyc 3.1.4.11-RXN
INTERPRO IPR009535
INTERPRO IPR001711
INTERPRO IPR014815

This term can be used instead of these obsolete terms:

GO:0007203 phosphatidylinositol-4,5-bisphosphate hydrolysis (consider GO:0004435)

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Ancestor Chart

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016298 lipase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0004620 phospholipase activity
GO:0004434 inositol or phosphatidylinositol phosphodiesterase activity
GO:0004629 phospholipase C activity
GO:0004435 phosphoinositide phospholipase C activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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