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GO:0004435 phosphatidylinositol phospholipase C activity

Term Information

ID GO:0004435
Name phosphatidylinositol phospholipase C activity
Ontology Molecular Function
Definition Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
GONUTS GO:0004435 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related phosphatidylinositol-4,5-bisphosphate hydrolysis
exact 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
exact 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
exact phosphoinositide phospholipase C activity
broad triphosphoinositide phosphodiesterase activity
exact phosphoinositidase C activity
broad monophosphatidylinositol phosphodiesterase activity
exact PI-PLC activity
exact 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.1.4.11
InterPro IPR001711
InterPro IPR009535
InterPro IPR014815
InterPro IPR016279
InterPro IPR016280
InterPro IPR028380
InterPro IPR028381
InterPro IPR028391
InterPro IPR028400
InterPro IPR028406
InterPro IPR028407
KEGG R03435
MetaCyc 3.1.4.11-RXN
RHEA 23915

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0007203 phosphatidylinositol-4,5-bisphosphate hydrolysis CONSIDER GO:0004435

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004435:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004435. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004435 based on the entire annotation set Co-occurrence statistics for GO:0004435 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-01-30 Updated TERM phosphatidylinositol phospholipase C activity
2011-01-30 Deleted SYNONYM phosphatidylinositol phospholipase C activity
2011-01-30 Added SYNONYM phosphoinositide phospholipase C activity
2010-10-11 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2010-10-11 Added XREF KEGG:R03435
2010-10-11 Added XREF RHEA:23915
2010-10-11 Deleted RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2010-10-07 Added RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2010-10-07 Deleted RELATION is a GO:0004434 (inositol or phosphatidylinositol phosphodiesterase activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2008-04-01 Updated RELATION is a GO:0004434 (inositol or phosphatidylinositol phosphodiesterase activity)
2008-04-01 Updated RELATION is a GO:0004629 (phospholipase C activity)
2007-11-08 Added SYNONYM 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
2007-09-06 Added SYNONYM phosphoinositidase C activity
2007-09-06 Added SYNONYM triphosphoinositide phosphodiesterase activity
2007-09-06 Added SYNONYM 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
2007-09-06 Added SYNONYM PI-PLC activity
2007-09-06 Added SYNONYM monophosphatidylinositol phosphodiesterase activity
2007-09-06 Added SYNONYM phosphatidylinositol phospholipase C activity
2007-08-09 Added SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2007-08-09 Added SYNONYM phosphatidylinositol-4,5-bisphosphate hydrolysis
2007-08-09 Deleted SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2007-08-09 Deleted SYNONYM phosphatidylinositol-4,5-bisphosphate hydrolysis
2005-08-10 Added SYNONYM phosphatidylinositol-4,5-bisphosphate hydrolysis
2004-04-19 Added SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2004-04-16 Deleted SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2003-10-27 Added SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2003-10-27 Added XREF MetaCyc:3.1.4.11-RXN
2003-09-10 Updated TERM phosphoinositide phospholipase C activity
2003-09-06 Updated TERM phosphoinositide phospholipase C
2003-03-19 Updated TERM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2002-02-06 Updated TERM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
2001-10-11 Updated TERM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
2001-04-03 Updated TERM 1-phosphatidylinositol-4,5-biphosphate phosphodiesterase
2001-03-30 Added XREF EC:3.1.4.11
2001-03-30 Added TERM 1-phosphatidylinositol-4,5-biphosphate phosphodiesterase

Term

Timestamp Action Category Detail
2011-01-30 Updated TERM phosphatidylinositol phospholipase C activity
2003-09-10 Updated TERM phosphoinositide phospholipase C activity
2003-09-06 Updated TERM phosphoinositide phospholipase C
2003-03-19 Updated TERM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2002-02-06 Updated TERM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
2001-10-11 Updated TERM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
2001-04-03 Updated TERM 1-phosphatidylinositol-4,5-biphosphate phosphodiesterase
2001-03-30 Added TERM 1-phosphatidylinositol-4,5-biphosphate phosphodiesterase

Definition/synonyms

Timestamp Action Category Detail
2011-01-30 Deleted SYNONYM phosphatidylinositol phospholipase C activity
2011-01-30 Added SYNONYM phosphoinositide phospholipase C activity
2010-10-11 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2008-05-13 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
2007-11-08 Added SYNONYM 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
2007-09-06 Added SYNONYM phosphoinositidase C activity
2007-09-06 Added SYNONYM triphosphoinositide phosphodiesterase activity
2007-09-06 Added SYNONYM 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity
2007-09-06 Added SYNONYM PI-PLC activity
2007-09-06 Added SYNONYM monophosphatidylinositol phosphodiesterase activity
2007-09-06 Added SYNONYM phosphatidylinositol phospholipase C activity
2007-08-09 Added SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2007-08-09 Added SYNONYM phosphatidylinositol-4,5-bisphosphate hydrolysis
2007-08-09 Deleted SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2007-08-09 Deleted SYNONYM phosphatidylinositol-4,5-bisphosphate hydrolysis
2005-08-10 Added SYNONYM phosphatidylinositol-4,5-bisphosphate hydrolysis
2004-04-19 Added SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2004-04-16 Deleted SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2003-10-27 Added SYNONYM 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Relationships

Timestamp Action Category Detail
2010-10-11 Deleted RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2010-10-07 Added RELATION is a GO:0008081 (phosphoric diester hydrolase activity)
2010-10-07 Deleted RELATION is a GO:0004434 (inositol or phosphatidylinositol phosphodiesterase activity)
2008-04-01 Updated RELATION is a GO:0004434 (inositol or phosphatidylinositol phosphodiesterase activity)
2008-04-01 Updated RELATION is a GO:0004629 (phospholipase C activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF KEGG:R03435
2010-10-11 Added XREF RHEA:23915
2003-10-27 Added XREF MetaCyc:3.1.4.11-RXN
2001-03-30 Added XREF EC:3.1.4.11
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