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GO:0004421 hydroxymethylglutaryl-CoA synthase activity

Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Term Information

ID GO:0004421
Name hydroxymethylglutaryl-CoA synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
Comment Note that this function was formerly EC:4.1.3.5.

Synonyms

Type Synonym
exact 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
exact 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
exact 3-hydroxy-3-methylglutaryl-CoA synthase activity
related hydroxymethylglutaryl coenzyme A-condensing enzyme
exact HMG-CoA synthase activity
exact acetoacetyl coenzyme A transacetase activity
exact beta-hydroxy-beta-methylglutaryl-CoA synthase activity
exact hydroxymethylglutaryl coenzyme A synthase activity
exact hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
exact (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
exact acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
exact 3-hydroxy-3-methylglutaryl CoA synthetase activity
exact (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
exact 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity

Cross-references associated with this term:

Database ID
MetaCyc HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
EC 2.3.3.10
INTERPRO IPR013746
INTERPRO IPR000590
INTERPRO IPR013528
INTERPRO IPR010122

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
GO:0004421 hydroxymethylglutaryl-CoA synthase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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