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GO:0004421 hydroxymethylglutaryl-CoA synthase activityCatalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
Term Information
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| Type | Synonym |
| exact | 3-hydroxy-3-methylglutaryl coenzyme A synthase activity |
| exact | 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity |
| exact | 3-hydroxy-3-methylglutaryl-CoA synthase activity |
| related | hydroxymethylglutaryl coenzyme A-condensing enzyme |
| exact | HMG-CoA synthase activity |
| exact | acetoacetyl coenzyme A transacetase activity |
| exact | beta-hydroxy-beta-methylglutaryl-CoA synthase activity |
| exact | hydroxymethylglutaryl coenzyme A synthase activity |
| exact | hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity |
| exact | (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) |
| exact | acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) |
| exact | 3-hydroxy-3-methylglutaryl CoA synthetase activity |
| exact | (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity |
| exact | 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity |
| Database | ID |
| MetaCyc | HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN |
| EC | 2.3.3.10 |
| INTERPRO | IPR013746 |
| INTERPRO | IPR000590 |
| INTERPRO | IPR013528 |
| INTERPRO | IPR010122 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||
![]() | GO:0003824 catalytic activity | ||||
![]() | ![]() | GO:0016740 transferase activity | |||
![]() | ![]() | ![]() | GO:0016746 transferase activity, transferring acyl groups | ||
![]() | ![]() | ![]() | ![]() | GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | |
![]() | ![]() | ![]() | ![]() | ![]() | GO:0004421 hydroxymethylglutaryl-CoA synthase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-22-04-02-35 |