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GO:0004421 hydroxymethylglutaryl-CoA synthase activity

Term Information

ID GO:0004421
Name hydroxymethylglutaryl-CoA synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
Comment Note that this function was formerly EC:4.1.3.5.
GONUTS GO:0004421 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
exact (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
exact 3-hydroxy-3-methylglutaryl-CoA synthase activity
exact 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
exact 3-hydroxy-3-methylglutaryl CoA synthetase activity
exact (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
exact hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
exact hydroxymethylglutaryl coenzyme A synthase activity
exact beta-hydroxy-beta-methylglutaryl-CoA synthase activity
exact acetoacetyl coenzyme A transacetase activity
exact HMG-CoA synthase activity
exact 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
exact acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
related hydroxymethylglutaryl coenzyme A-condensing enzyme

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.3.3.10
InterPro IPR000590
InterPro IPR010122
InterPro IPR013528
InterPro IPR013746
KEGG R01978
MetaCyc HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
RHEA 10191

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004421:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004421. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004421 based on the entire annotation set Co-occurrence statistics for GO:0004421 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2010-10-11 Added DEFINITION Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
2010-10-11 Added XREF KEGG:R01978
2010-10-11 Added XREF RHEA:10191
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2008-04-01 Updated RELATION is a GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
2007-11-08 Added SYNONYM (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
2007-11-08 Added SYNONYM acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2007-11-08 Added SYNONYM hydroxymethylglutaryl coenzyme A-condensing enzyme
2007-09-06 Added SYNONYM HMG-CoA synthase activity
2007-09-06 Added SYNONYM acetoacetyl coenzyme A transacetase activity
2007-09-06 Added SYNONYM beta-hydroxy-beta-methylglutaryl-CoA synthase activity
2007-09-06 Added SYNONYM hydroxymethylglutaryl coenzyme A synthase activity
2007-09-06 Added SYNONYM hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
2007-09-06 Added SYNONYM (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl CoA synthetase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl-CoA synthase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2003-10-27 Added XREF MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
2003-09-05 Added XREF EC:2.3.3.10
2003-09-05 Deleted XREF EC:4.1.3.5
2003-03-19 Updated TERM hydroxymethylglutaryl-CoA synthase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + CoA = acetyl-CoA + H2O + acetoacetyl-CoA.
2002-02-06 Updated TERM hydroxymethylglutaryl-CoA synthase
2001-08-06 Added DEFINITION Enzyme that catalyzes the formation of hydroxymethylglutaryl-CoA (HMG-CoA) from acteyl-CoA and acetoacetyl-CoA.
2001-04-03 Updated TERM hydroxymethylglutaryl-CoA synthase
2001-03-30 Added XREF EC:4.1.3.5
2001-03-30 Added TERM hydroxymethylglutaryl-CoA synthase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM hydroxymethylglutaryl-CoA synthase activity
2002-02-06 Updated TERM hydroxymethylglutaryl-CoA synthase
2001-04-03 Updated TERM hydroxymethylglutaryl-CoA synthase
2001-03-30 Added TERM hydroxymethylglutaryl-CoA synthase

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2010-10-11 Added DEFINITION Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2007-11-08 Added SYNONYM (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
2007-11-08 Added SYNONYM acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2007-11-08 Added SYNONYM hydroxymethylglutaryl coenzyme A-condensing enzyme
2007-09-06 Added SYNONYM HMG-CoA synthase activity
2007-09-06 Added SYNONYM acetoacetyl coenzyme A transacetase activity
2007-09-06 Added SYNONYM beta-hydroxy-beta-methylglutaryl-CoA synthase activity
2007-09-06 Added SYNONYM hydroxymethylglutaryl coenzyme A synthase activity
2007-09-06 Added SYNONYM hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity
2007-09-06 Added SYNONYM (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl CoA synthetase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl coenzyme A synthase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl coenzyme A synthetase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl-CoA synthase activity
2007-09-06 Added SYNONYM 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
2002-11-27 Updated DEFINITION Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + CoA = acetyl-CoA + H2O + acetoacetyl-CoA.
2001-08-06 Added DEFINITION Enzyme that catalyzes the formation of hydroxymethylglutaryl-CoA (HMG-CoA) from acteyl-CoA and acetoacetyl-CoA.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF KEGG:R01978
2010-10-11 Added XREF RHEA:10191
2003-10-27 Added XREF MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
2003-09-05 Added XREF EC:2.3.3.10
2003-09-05 Deleted XREF EC:4.1.3.5
2001-03-30 Added XREF EC:4.1.3.5
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