spacer

GO:0004386 helicase activity

Term Information

ID GO:0004386
Name helicase activity
Ontology Molecular Function
Definition Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
Comment Note that most helicases catalyze processive duplex unwinding.
GONUTS GO:0004386 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_candida89
goslim_pir462
goslim_yeast169
goslim_generic149
goslim_aspergillus85

Cross-references

Database ID
InterPro IPR003840
InterPro IPR004004
InterPro IPR007502
InterPro IPR010003
InterPro IPR012562
InterPro IPR013237
InterPro IPR018999
UniProtKB-KW Helicase

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004386:
Relationship To GO:0004386 Child Term Child Term Name
Is a GO:0003678 DNA helicase activity
Is a GO:0003724 RNA helicase activity
Is a GO:0033677 DNA/RNA helicase activity
Regulates GO:0051095 regulation of helicase activity
Positively regulates GO:0051096 positive regulation of helicase activity
Negatively regulates GO:0051097 negative regulation of helicase activity
Is a GO:0070035 purine NTP-dependent helicase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004386. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004386 based on the entire annotation set Co-occurrence statistics for GO:0004386 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2010-09-03 Deleted DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix.
2010-09-03 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
2008-10-02 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix.
2008-10-02 Deleted DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2008-10-02 Added RELATION is a GO:0017111 (nucleoside-triphosphatase activity)
2008-10-02 Deleted RELATION is a GO:0003824 (catalytic activity)
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2008-05-12 Deleted DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)
2004-09-29 Updated TERM helicase activity
2003-03-19 Updated TERM helicase activity
2002-11-27 Added DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2002-02-06 Updated TERM helicase
2001-04-03 Updated TERM helicase
2001-03-30 Added TERM helicase

Term

Timestamp Action Category Detail
2004-09-29 Updated TERM helicase activity
2003-03-19 Updated TERM helicase activity
2002-02-06 Updated TERM helicase
2001-04-03 Updated TERM helicase
2001-03-30 Added TERM helicase

Definition/synonyms

Timestamp Action Category Detail
2010-09-03 Deleted DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix.
2010-09-03 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.
2008-10-02 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix.
2008-10-02 Deleted DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2008-05-13 Added DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2008-05-12 Deleted DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.
2002-11-27 Added DEFINITION Catalysis of the unwinding of a DNA or RNA duplex.

Relationships

Timestamp Action Category Detail
2008-10-02 Added RELATION is a GO:0017111 (nucleoside-triphosphatase activity)
2008-10-02 Deleted RELATION is a GO:0003824 (catalytic activity)
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_candida
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms