spacer

GO:0004383 guanylate cyclase activity

Term Information

ID GO:0004383
Name guanylate cyclase activity
Ontology Molecular Function
Definition Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
GONUTS GO:0004383 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact guanyl cyclase activity
narrow receptor guanylate cyclase activity
exact guanylyl cyclase activity
exact GTP diphosphate-lyase (cyclizing) activity
exact GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 4.6.1.2
InterPro IPR011645
MetaCyc GUANYLCYC-RXN
RHEA 13668

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008075 receptor guanylate cyclase activity CONSIDER GO:0004383

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004383:
Relationship To GO:0004383 Child Term Child Term Name
Regulates GO:0030249 guanylate cyclase regulator activity
Positively regulates GO:0030250 guanylate cyclase activator activity
Negatively regulates GO:0030251 guanylate cyclase inhibitor activity
Regulates GO:0031282 regulation of guanylate cyclase activity
Negatively regulates GO:0031283 negative regulation of guanylate cyclase activity
Positively regulates GO:0031284 positive regulation of guanylate cyclase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004383. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004383 based on the entire annotation set Co-occurrence statistics for GO:0004383 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:13668
2010-06-15 Added RELATION part of GO:0006182 (cGMP biosynthetic process)
2010-06-14 Deleted RELATION part of GO:0006182 (cGMP biosynthetic process)
2010-06-08 Added RELATION part of GO:0006182 (cGMP biosynthetic process)
2008-05-13 Added DEFINITION Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2008-04-01 Updated RELATION is a GO:0009975 (cyclase activity)
2008-04-01 Updated RELATION is a GO:0016849 (phosphorus-oxygen lyase activity)
2007-12-14 Added SYNONYM GTP diphosphate-lyase (cyclizing) activity
2007-12-14 Added SYNONYM GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
2007-09-06 Added SYNONYM guanyl cyclase activity
2007-08-09 Added SYNONYM guanylyl cyclase activity
2007-08-09 Added SYNONYM receptor guanylate cyclase activity
2007-08-09 Deleted SYNONYM guanylyl cyclase activity
2007-08-09 Deleted SYNONYM receptor guanylate cyclase activity
2005-08-10 Added SYNONYM receptor guanylate cyclase activity
2004-12-12 Added SYNONYM guanylyl cyclase activity
2003-10-27 Added XREF MetaCyc:GUANYLCYC-RXN
2003-03-19 Updated TERM guanylate cyclase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2002-02-06 Updated TERM guanylate cyclase
2001-04-03 Updated TERM guanylate cyclase
2001-03-30 Added XREF EC:4.6.1.2
2001-03-30 Added TERM guanylate cyclase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM guanylate cyclase activity
2002-02-06 Updated TERM guanylate cyclase
2001-04-03 Updated TERM guanylate cyclase
2001-03-30 Added TERM guanylate cyclase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2007-12-14 Added SYNONYM GTP diphosphate-lyase (cyclizing) activity
2007-12-14 Added SYNONYM GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity
2007-09-06 Added SYNONYM guanyl cyclase activity
2007-08-09 Added SYNONYM guanylyl cyclase activity
2007-08-09 Added SYNONYM receptor guanylate cyclase activity
2007-08-09 Deleted SYNONYM guanylyl cyclase activity
2007-08-09 Deleted SYNONYM receptor guanylate cyclase activity
2005-08-10 Added SYNONYM receptor guanylate cyclase activity
2004-12-12 Added SYNONYM guanylyl cyclase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0006182 (cGMP biosynthetic process)
2010-06-14 Deleted RELATION part of GO:0006182 (cGMP biosynthetic process)
2010-06-08 Added RELATION part of GO:0006182 (cGMP biosynthetic process)
2008-04-01 Updated RELATION is a GO:0009975 (cyclase activity)
2008-04-01 Updated RELATION is a GO:0016849 (phosphorus-oxygen lyase activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:13668
2003-10-27 Added XREF MetaCyc:GUANYLCYC-RXN
2001-03-30 Added XREF EC:4.6.1.2
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
15ms