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GO:0004353 glutamate dehydrogenase [NAD(P)+] activity

Term Information

ID GO:0004353
Name glutamate dehydrogenase [NAD(P)+] activity
Ontology Molecular Function
Definition Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
Comment Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
GONUTS GO:0004353 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
broad glutamic dehydrogenase activity
exact L-glutamate:NAD(P)+ oxidoreductase (deaminating)
related glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
related glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.4.1.3
MetaCyc GLUTAMATE-DEHYDROGENASE-NADP+-RXN
MetaCyc GLUTAMATE-SYN2-PWY

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0019268 glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) REPLACEDBY GO:0004353

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004353:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004353. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004353 based on the entire annotation set Co-occurrence statistics for GO:0004353 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-05-21 Deleted XREF MetaCyc:GLUTAMATE-DEHYDROGENASE-(NAD(P)+)-RXN
2009-05-21 Added XREF MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
2008-05-13 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
2008-04-01 Updated RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)
2007-11-08 Added SYNONYM L-glutamate:NAD(P)+ oxidoreductase (deaminating)
2007-09-06 Added SYNONYM glutamic dehydrogenase activity
2007-08-09 Added SYNONYM glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
2007-08-09 Added SYNONYM glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
2007-08-09 Deleted SYNONYM glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
2007-08-09 Deleted SYNONYM glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
2007-01-15 Added SYNONYM glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
2005-08-10 Added SYNONYM glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
2004-05-21 Updated DEFINITION Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
2004-01-07 Updated TERM glutamate dehydrogenase [NAD(P)+] activity
2003-11-14 Added XREF MetaCyc:GLUTAMATE-SYN2-PWY
2003-10-30 Updated DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2003-10-27 Added XREF MetaCyc:GLUTAMATE-DEHYDROGENASE-(NAD(P)+)-RXN
2003-09-06 Updated TERM glutamate dehydrogenase [NAD(P)] activity
2003-03-19 Updated TERM glutamate dehydrogenase (NAD(P)+) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + ammonia + NADPH + H+.
2002-02-06 Updated TERM glutamate dehydrogenase (NAD(P)+)
2001-04-03 Updated TERM glutamate dehydrogenase (NAD(P)+)
2001-03-30 Added XREF EC:1.4.1.3
2001-03-30 Added TERM glutamate dehydrogenase (NAD(P)+)

Term

Timestamp Action Category Detail
2004-01-07 Updated TERM glutamate dehydrogenase [NAD(P)+] activity
2003-09-06 Updated TERM glutamate dehydrogenase [NAD(P)] activity
2003-03-19 Updated TERM glutamate dehydrogenase (NAD(P)+) activity
2002-02-06 Updated TERM glutamate dehydrogenase (NAD(P)+)
2001-04-03 Updated TERM glutamate dehydrogenase (NAD(P)+)
2001-03-30 Added TERM glutamate dehydrogenase (NAD(P)+)

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
2007-11-08 Added SYNONYM L-glutamate:NAD(P)+ oxidoreductase (deaminating)
2007-09-06 Added SYNONYM glutamic dehydrogenase activity
2007-08-09 Added SYNONYM glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
2007-08-09 Added SYNONYM glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
2007-08-09 Deleted SYNONYM glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
2007-08-09 Deleted SYNONYM glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
2007-01-15 Added SYNONYM glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
2005-08-10 Added SYNONYM glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)
2004-05-21 Updated DEFINITION Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.
2003-10-30 Updated DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.
2002-11-27 Added DEFINITION Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + ammonia + NADPH + H+.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2009-05-21 Deleted XREF MetaCyc:GLUTAMATE-DEHYDROGENASE-(NAD(P)+)-RXN
2009-05-21 Added XREF MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
2003-11-14 Added XREF MetaCyc:GLUTAMATE-SYN2-PWY
2003-10-27 Added XREF MetaCyc:GLUTAMATE-DEHYDROGENASE-(NAD(P)+)-RXN
2001-03-30 Added XREF EC:1.4.1.3
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