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GO:0004312 fatty acid synthase activity

Term Information

ID GO:0004312
Name fatty acid synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
GONUTS GO:0004312 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
exact fatty-acid synthase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.3.1.85
InterPro IPR003965
InterPro IPR023102
MetaCyc FATTY-ACID-SYNTHASE-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004312:
Relationship To GO:0004312 Child Term Child Term Name
Is a GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity
Is a GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
Is a GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
Is a GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Is a GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
Is a GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
Is a GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
Is a GO:0009922 fatty acid elongase activity
Is a GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004312. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004312 based on the entire annotation set Co-occurrence statistics for GO:0004312 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-07-31 Added RELATION is a GO:0016747 (transferase activity, transferring acyl groups other than amino-acyl groups)
2011-07-31 Deleted RELATION is a GO:0008415 (acyltransferase activity)
2010-05-13 Added SYNONYM fatty-acid synthase activity
2010-05-13 Updated TERM fatty acid synthase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2008-04-01 Updated RELATION is a GO:0008415 (acyltransferase activity)
2007-11-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2003-10-27 Added XREF MetaCyc:FATTY-ACID-SYNTHASE-RXN
2003-10-24 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2003-03-19 Updated TERM fatty-acid synthase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
2002-02-06 Updated TERM fatty-acid synthase
2001-04-03 Updated TERM fatty-acid synthase
2001-03-30 Added XREF EC:2.3.1.85
2001-03-30 Added TERM fatty-acid synthase

Term

Timestamp Action Category Detail
2010-05-13 Updated TERM fatty acid synthase activity
2003-03-19 Updated TERM fatty-acid synthase activity
2002-02-06 Updated TERM fatty-acid synthase
2001-04-03 Updated TERM fatty-acid synthase
2001-03-30 Added TERM fatty-acid synthase

Definition/synonyms

Timestamp Action Category Detail
2010-05-13 Added SYNONYM fatty-acid synthase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2007-11-08 Added SYNONYM acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2003-10-24 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
2002-11-27 Added DEFINITION Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + H+ = long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.

Relationships

Timestamp Action Category Detail
2011-07-31 Added RELATION is a GO:0016747 (transferase activity, transferring acyl groups other than amino-acyl groups)
2011-07-31 Deleted RELATION is a GO:0008415 (acyltransferase activity)
2008-04-01 Updated RELATION is a GO:0008415 (acyltransferase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:FATTY-ACID-SYNTHASE-RXN
2001-03-30 Added XREF EC:2.3.1.85
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