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GO:0004308 exo-alpha-sialidase activity

Term Information

ID GO:0004308
Name exo-alpha-sialidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
GONUTS GO:0004308 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact neuraminidase activity
exact sialidase activity
exact acetylneuraminidase activity
exact acetylneuraminyl hydrolase activity
exact N-acylneuraminate glycohydrolase activity
exact alpha-neuraminidase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.2.1.18
InterPro IPR001860
InterPro IPR004124
InterPro IPR008377
InterPro IPR016285
InterPro IPR026856
InterPro IPR026944
InterPro IPR026945
InterPro IPR026946
MetaCyc 3.2.1.18-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004308:
Relationship To GO:0004308 Child Term Child Term Name
Regulates GO:1903015 regulation of exo-alpha-sialidase activity
Negatively regulates GO:1903016 negative regulation of exo-alpha-sialidase activity
Positively regulates GO:1903017 positive regulation of exo-alpha-sialidase activity
Is a GO:0052794 exo-alpha-(2->3)-sialidase activity
Is a GO:0052795 exo-alpha-(2->6)-sialidase activity
Is a GO:0052796 exo-alpha-(2->8)-sialidase activity
Regulates GO:0044866 modulation by host of viral exo-alpha-sialidase activity
Negatively regulates GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004308. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004308 based on the entire annotation set Co-occurrence statistics for GO:0004308 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
2008-04-01 Updated RELATION is a GO:0016997 (alpha-sialidase activity)
2007-11-08 Added SYNONYM acetylneuraminidase activity
2007-11-08 Added SYNONYM acetylneuraminyl hydrolase activity
2007-09-06 Deleted SYNONYM neuraminidase
2007-09-06 Added SYNONYM N-acylneuraminate glycohydrolase activity
2007-09-06 Added SYNONYM alpha-neuraminidase activity
2007-09-06 Added SYNONYM neuraminidase activity
2007-09-06 Added SYNONYM sialidase activity
2007-08-09 Added SYNONYM neuraminidase
2007-08-09 Deleted SYNONYM neuraminidase
2004-04-19 Added SYNONYM neuraminidase
2004-04-16 Deleted SYNONYM neuraminidase
2003-10-27 Added SYNONYM neuraminidase
2003-10-27 Added XREF MetaCyc:3.2.1.18-RXN
2003-08-18 Deleted SYNONYM neuraminidase
2003-03-19 Updated TERM exo-alpha-sialidase activity
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
2002-02-06 Updated TERM exo-alpha-sialidase
2001-04-03 Updated TERM exo-alpha-sialidase
2001-03-30 Added XREF EC:3.2.1.18
2001-03-30 Added SYNONYM neuraminidase
2001-03-30 Added TERM exo-alpha-sialidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM exo-alpha-sialidase activity
2002-02-06 Updated TERM exo-alpha-sialidase
2001-04-03 Updated TERM exo-alpha-sialidase
2001-03-30 Added TERM exo-alpha-sialidase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
2007-11-08 Added SYNONYM acetylneuraminidase activity
2007-11-08 Added SYNONYM acetylneuraminyl hydrolase activity
2007-09-06 Deleted SYNONYM neuraminidase
2007-09-06 Added SYNONYM N-acylneuraminate glycohydrolase activity
2007-09-06 Added SYNONYM alpha-neuraminidase activity
2007-09-06 Added SYNONYM neuraminidase activity
2007-09-06 Added SYNONYM sialidase activity
2007-08-09 Added SYNONYM neuraminidase
2007-08-09 Deleted SYNONYM neuraminidase
2004-04-19 Added SYNONYM neuraminidase
2004-04-16 Deleted SYNONYM neuraminidase
2003-10-27 Added SYNONYM neuraminidase
2003-08-18 Deleted SYNONYM neuraminidase
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
2001-03-30 Added SYNONYM neuraminidase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016997 (alpha-sialidase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.2.1.18-RXN
2001-03-30 Added XREF EC:3.2.1.18
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