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GO:0004303 estradiol 17-beta-dehydrogenase activity

Term Information

ID GO:0004303
Name estradiol 17-beta-dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
GONUTS GO:0004303 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact estradiol dehydrogenase activity
broad 17-beta-HSD activity
exact 17-beta-estradiol dehydrogenase activity
exact estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
exact 17beta-estradiol dehydrogenase activity
related 17beta-HSD
exact 17beta,20alpha-hydroxysteroid dehydrogenase activity
exact estradiol 17beta-dehydrogenase activity
broad 20alpha-hydroxysteroid dehydrogenase
exact 17beta-hydroxysteroid dehydrogenase activity
exact estrogen 17-oxidoreductase activity
broad 17-beta-hydroxysteroid dehydrogenase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.62
InterPro IPR011348
MetaCyc ESTRADIOL-17-BETA-DEHYDROGENASE-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004303:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004303. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004303 based on the entire annotation set Co-occurrence statistics for GO:0004303 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
2008-04-01 Updated RELATION is a GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2007-11-08 Added SYNONYM 17beta,20alpha-hydroxysteroid dehydrogenase activity
2007-11-08 Added SYNONYM 17beta-HSD
2007-11-08 Added SYNONYM 17beta-estradiol dehydrogenase activity
2007-11-08 Added SYNONYM 17beta-hydroxysteroid dehydrogenase activity
2007-11-08 Added SYNONYM 20alpha-hydroxysteroid dehydrogenase
2007-11-08 Added SYNONYM estradiol 17beta-dehydrogenase activity
2007-11-08 Added SYNONYM estradiol dehydrogenase activity
2007-11-08 Added SYNONYM estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
2007-09-06 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2007-09-06 Added SYNONYM 17-beta-HSD activity
2007-09-06 Added SYNONYM 17-beta-estradiol dehydrogenase activity
2007-09-06 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase activity
2007-09-06 Added SYNONYM estrogen 17-oxidoreductase activity
2007-08-09 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2007-08-09 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2004-04-19 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2004-04-16 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2003-10-27 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2003-10-27 Added XREF MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
2003-09-09 Updated TERM estradiol 17-beta-dehydrogenase activity
2003-08-21 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2003-03-19 Updated TERM estradiol 17 beta-dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
2002-02-06 Updated TERM estradiol 17 beta-dehydrogenase
2001-04-03 Updated TERM estradiol 17 beta-dehydrogenase
2001-03-30 Added XREF EC:1.1.1.62
2001-03-30 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2001-03-30 Added TERM estradiol 17 beta-dehydrogenase

Term

Timestamp Action Category Detail
2003-09-09 Updated TERM estradiol 17-beta-dehydrogenase activity
2003-03-19 Updated TERM estradiol 17 beta-dehydrogenase activity
2002-02-06 Updated TERM estradiol 17 beta-dehydrogenase
2001-04-03 Updated TERM estradiol 17 beta-dehydrogenase
2001-03-30 Added TERM estradiol 17 beta-dehydrogenase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
2007-11-08 Added SYNONYM 17beta,20alpha-hydroxysteroid dehydrogenase activity
2007-11-08 Added SYNONYM 17beta-HSD
2007-11-08 Added SYNONYM 17beta-estradiol dehydrogenase activity
2007-11-08 Added SYNONYM 17beta-hydroxysteroid dehydrogenase activity
2007-11-08 Added SYNONYM 20alpha-hydroxysteroid dehydrogenase
2007-11-08 Added SYNONYM estradiol 17beta-dehydrogenase activity
2007-11-08 Added SYNONYM estradiol dehydrogenase activity
2007-11-08 Added SYNONYM estradiol-17beta:NAD(P)+ 17-oxidoreductase activity
2007-09-06 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2007-09-06 Added SYNONYM 17-beta-HSD activity
2007-09-06 Added SYNONYM 17-beta-estradiol dehydrogenase activity
2007-09-06 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase activity
2007-09-06 Added SYNONYM estrogen 17-oxidoreductase activity
2007-08-09 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2007-08-09 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2004-04-19 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2004-04-16 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2003-10-27 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase
2003-08-21 Deleted SYNONYM 17-beta-hydroxysteroid dehydrogenase
2002-11-27 Added DEFINITION Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
2001-03-30 Added SYNONYM 17-beta-hydroxysteroid dehydrogenase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.1.1.62
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