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GO:0004298 threonine-type endopeptidase activity

Term Information

ID GO:0004298
Name threonine-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
GONUTS GO:0004298 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow tricorn protease
narrow lens neutral proteinase
exact threonine endopeptidase activity
related 26S protease
narrow tricorn proteinase
related multicatalytic endopeptidase complex
narrow multicatalytic proteinase
narrow large multicatalytic protease
related MCP
related alkaline protease
related ingensin
narrow proteasome endopeptidase complex
related prosome
narrow multicatalytic proteinase (complex)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.25
InterPro IPR001353
InterPro IPR016295
InterPro IPR019982
InterPro IPR022281
InterPro IPR022296
InterPro IPR022483
InterPro IPR023332
InterPro IPR023333
UniProtKB-KW Threonine protease

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004298:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004298. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004298 based on the entire annotation set Co-occurrence statistics for GO:0004298 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-04-10 Added SYNONYM 26S protease
2011-04-10 Deleted SYNONYM 26S protease
2008-08-18 Added RELATION is a GO:0070003 (threonine-type peptidase activity)
2008-08-18 Added SYNONYM threonine endopeptidase activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-08-18 Updated TERM threonine-type endopeptidase activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
2007-12-14 Added SYNONYM 26S protease
2007-12-14 Added SYNONYM MCP
2007-12-14 Added SYNONYM alkaline protease
2007-12-14 Added SYNONYM ingensin
2007-12-14 Added SYNONYM large multicatalytic protease
2007-12-14 Added SYNONYM lens neutral proteinase
2007-12-14 Added SYNONYM multicatalytic endopeptidase complex
2007-12-14 Added SYNONYM multicatalytic proteinase
2007-12-14 Added SYNONYM multicatalytic proteinase (complex)
2007-12-14 Added SYNONYM prosome
2007-12-14 Added SYNONYM proteasome endopeptidase complex
2007-12-14 Added SYNONYM tricorn protease
2007-12-14 Added SYNONYM tricorn proteinase
2006-02-09 Added XREF EC:3.4.25
2006-02-09 Deleted XREF EC:3.4.25.-
2004-09-11 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2003-03-19 Updated TERM threonine endopeptidase activity
2002-02-06 Updated TERM threonine endopeptidase
2001-04-03 Updated TERM threonine endopeptidase
2001-03-30 Added XREF EC:3.4.25.-
2001-03-30 Added TERM threonine endopeptidase

Term

Timestamp Action Category Detail
2008-08-18 Updated TERM threonine-type endopeptidase activity
2003-03-19 Updated TERM threonine endopeptidase activity
2002-02-06 Updated TERM threonine endopeptidase
2001-04-03 Updated TERM threonine endopeptidase
2001-03-30 Added TERM threonine endopeptidase

Definition/synonyms

Timestamp Action Category Detail
2011-04-10 Added SYNONYM 26S protease
2011-04-10 Deleted SYNONYM 26S protease
2008-08-18 Added SYNONYM threonine endopeptidase activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.
2007-12-14 Added SYNONYM 26S protease
2007-12-14 Added SYNONYM MCP
2007-12-14 Added SYNONYM alkaline protease
2007-12-14 Added SYNONYM ingensin
2007-12-14 Added SYNONYM large multicatalytic protease
2007-12-14 Added SYNONYM lens neutral proteinase
2007-12-14 Added SYNONYM multicatalytic endopeptidase complex
2007-12-14 Added SYNONYM multicatalytic proteinase
2007-12-14 Added SYNONYM multicatalytic proteinase (complex)
2007-12-14 Added SYNONYM prosome
2007-12-14 Added SYNONYM proteasome endopeptidase complex
2007-12-14 Added SYNONYM tricorn protease
2007-12-14 Added SYNONYM tricorn proteinase
2004-09-11 Added DEFINITION Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles.

Relationships

Timestamp Action Category Detail
2008-08-18 Added RELATION is a GO:0070003 (threonine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.25
2006-02-09 Deleted XREF EC:3.4.25.-
2001-03-30 Added XREF EC:3.4.25.-
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