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GO:0004252 serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Term Information

ID	GO:0004252
Name	serine-type endopeptidase activity
Ontology	Molecular Function
Definition	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Comment

Synonyms

Type	Synonym
related	blood coagulation factor activity

Cross-references associated with this term:

Database	ID
INTERPRO	IPR008353
INTERPRO	IPR008357
INTERPRO	IPR008268
INTERPRO	IPR008269
INTERPRO	IPR000930
INTERPRO	IPR006604
INTERPRO	IPR005319
INTERPRO	IPR011357
INTERPRO	IPR011358
INTERPRO	IPR011360
INTERPRO	IPR011361
INTERPRO	IPR001907
INTERPRO	IPR001940
INTERPRO	IPR014394
INTERPRO	IPR013192
INTERPRO	IPR001316
INTERPRO	IPR017329
INTERPRO	IPR000280
INTERPRO	IPR006199
INTERPRO	IPR006200
INTERPRO	IPR000177
INTERPRO	IPR000209
INTERPRO	IPR017324
INTERPRO	IPR017326
INTERPRO	IPR011782
INTERPRO	IPR011783
INTERPRO	IPR012051
INTERPRO	IPR012267
INTERPRO	IPR004093
INTERPRO	IPR004106
INTERPRO	IPR001984
INTERPRO	IPR002169
INTERPRO	IPR012224
INTERPRO	IPR018114
INTERPRO	IPR011165
INTERPRO	IPR011164
INTERPRO	IPR011163
EC	3.4.21
INTERPRO	IPR002884
INTERPRO	IPR013703
INTERPRO	IPR001254
INTERPRO	IPR001314
INTERPRO	IPR003966
INTERPRO	IPR010435
INTERPRO	IPR002533
INTERPRO	IPR002548
INTERPRO	IPR008741
INTERPRO	IPR008742
INTERPRO	IPR001490
INTERPRO	IPR002868
INTERPRO	IPR017213
INTERPRO	IPR017092
INTERPRO	IPR018992
INTERPRO	IPR001815
INTERPRO	IPR001847
INTERPRO	IPR002470
INTERPRO	IPR002471
INTERPRO	IPR013510
INTERPRO	IPR013661
INTERPRO	IPR018215
INTERPRO	IPR008760
INTERPRO	IPR000710
INTERPRO	IPR008124
INTERPRO	IPR010259
INTERPRO	IPR013193
INTERPRO	IPR017051
INTERPRO	IPR015352
INTERPRO	IPR000487
INTERPRO	IPR005073

This term can be used instead of these obsolete terms:

GO:0004277 granzyme A activity	(replaced_by GO:0004252)
GO:0004278 granzyme B activity	(replaced_by GO:0004252)
GO:0004281 pancreatic elastase II activity	(replaced_by GO:0004252)
GO:0004283 plasmin activity	(replaced_by GO:0004252)
GO:0004284 acrosin activity	(replaced_by GO:0004252)
GO:0004285 proprotein convertase 1 activity	(replaced_by GO:0004252)
GO:0004286 proprotein convertase 2 activity	(replaced_by GO:0004252)
GO:0004287 prolyl oligopeptidase activity	(replaced_by GO:0004252)
GO:0004289 subtilase activity	(replaced_by GO:0004252)
GO:0004290 kexin activity	(replaced_by GO:0004252)
GO:0004291 subtilisin activity	(replaced_by GO:0004252)
GO:0004293 tissue kallikrein activity	(replaced_by GO:0004252)
GO:0004295 trypsin activity	(replaced_by GO:0004252)
GO:0008125 pancreatic elastase I activity	(replaced_by GO:0004252)
GO:0008130 neutrophil collagenase activity	(replaced_by GO:0004252)
GO:0008132 pancreatic elastase activity	(replaced_by GO:0004252)
GO:0008243 plasminogen activator activity	(replaced_by GO:0004252)
GO:0008439 monophenol monooxygenase activator activity	(replaced_by GO:0004252)
GO:0008462 endopeptidase Clp activity	(replaced_by GO:0004252)
GO:0008846 endopeptidase La activity	(replaced_by GO:0004252)
GO:0008931 murein DD-endopeptidase activity	(replaced_by GO:0004252)
GO:0008945 oligopeptidase B activity	(replaced_by GO:0004252)
GO:0008947 omptin activity	(replaced_by GO:0004252)
GO:0003802 coagulation factor VIIa activity	(replaced_by GO:0004252)
GO:0003803 coagulation factor IXa activity	(replaced_by GO:0004252)
GO:0003804 coagulation factor Xa activity	(replaced_by GO:0004252)
GO:0003805 coagulation factor XIa activity	(replaced_by GO:0004252)
GO:0003806 coagulation factor XIIa activity	(replaced_by GO:0004252)
GO:0003807 plasma kallikrein activity	(replaced_by GO:0004252)
GO:0003808 protein C (activated) activity	(replaced_by GO:0004252)
GO:0003809 thrombin activity	(replaced_by GO:0004252)
GO:0003812 alternative-complement-pathway C3/C5 convertase activity	(replaced_by GO:0004252)
GO:0003813 classical-complement-pathway C3/C5 convertase activity	(replaced_by GO:0004252)
GO:0003815 complement component C1r activity	(replaced_by GO:0004252)
GO:0003816 complement component C1s activity	(replaced_by GO:0004252)
GO:0003817 complement factor D activity	(replaced_by GO:0004252)
GO:0003818 complement factor I activity	(replaced_by GO:0004252)
GO:0003801 blood coagulation factor activity	(consider GO:0004252)
GO:0008981 protease IV activity	(replaced_by GO:0004252)
GO:0008991 serine-type signal peptidase activity	(replaced_by GO:0004252)
GO:0008992 repressor LexA activity	(replaced_by GO:0004252)
GO:0009004 signal peptidase I activity	(replaced_by GO:0004252)
GO:0016808 proprotein convertase activity	(replaced_by GO:0004252)
GO:0019132 C-terminal processing peptidase activity	(replaced_by GO:0004252)
GO:0030019 tryptase activity	(replaced_by GO:0004252)
GO:0030271 chymase activity	(replaced_by GO:0004252)
GO:0030403 collagenase 4 activity	(replaced_by GO:0004252)
GO:0030404 collagenase 3 activity	(replaced_by GO:0004252)
GO:0051405 microbial collagenase activity	(replaced_by GO:0004252)
GO:0004232 interstitial collagenase activity	(replaced_by GO:0004252)
GO:0004253 gamma-renin activity	(replaced_by GO:0004252)
GO:0004254 acylaminoacyl-peptidase activity	(replaced_by GO:0004252)
GO:0004261 cathepsin G activity	(replaced_by GO:0004252)
GO:0004262 cerevisin activity	(replaced_by GO:0004252)
GO:0004263 chymotrypsin activity	(replaced_by GO:0004252)
GO:0004275 enteropeptidase activity	(replaced_by GO:0004252)
GO:0004276 furin activity	(replaced_by GO:0004252)

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GO:0003674 molecular_function

GO:0003824 catalytic activity

GO:0016787 hydrolase activity

GO:0008233 peptidase activity

GO:0017171 serine hydrolase activity

GO:0070011 peptidase activity, acting on L-amino acid peptides

GO:0004175 endopeptidase activity

GO:0008236 serine-type peptidase activity

GO:0004252 serine-type endopeptidase activity

Relationship key

Code	Relationship
	part of
	is a
	regulates
	+ve regulates
	-ve regulates

Child Terms

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Protein Annotation

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GAnnotation?format=tsv&limit=max-number-of-rows{&gz}{&q=advanced query}{&field=value{,value}}

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Co-occurring Terms

Co-occurrence statistics

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