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GO:0004252 serine-type endopeptidase activity

Term Information

ID GO:0004252
Name serine-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
GONUTS GO:0004252 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related blood coagulation factor activity
related serine elastase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.21
InterPro IPR000209
InterPro IPR000280
InterPro IPR000382
InterPro IPR000487
InterPro IPR000710
InterPro IPR000930
InterPro IPR001254
InterPro IPR001314
InterPro IPR001316
InterPro IPR001490
InterPro IPR001528
InterPro IPR001815
InterPro IPR001847
InterPro IPR001907
InterPro IPR001940
InterPro IPR001984
InterPro IPR002169
InterPro IPR002470
InterPro IPR002471
InterPro IPR002518
InterPro IPR002533
InterPro IPR002548
InterPro IPR002610
InterPro IPR002868
InterPro IPR002884
InterPro IPR003966
InterPro IPR004106
InterPro IPR005073
InterPro IPR005319
InterPro IPR006199
InterPro IPR006200
InterPro IPR006604
InterPro IPR008268
InterPro IPR008269
InterPro IPR008353
InterPro IPR008357
InterPro IPR008760
InterPro IPR010435
InterPro IPR011163
InterPro IPR011360
InterPro IPR011782
InterPro IPR011783
InterPro IPR012224
InterPro IPR012267
InterPro IPR013703
InterPro IPR014394
InterPro IPR014412
InterPro IPR015352
InterPro IPR017051
InterPro IPR017052
InterPro IPR017092
InterPro IPR017213
InterPro IPR017324
InterPro IPR017326
InterPro IPR017329
InterPro IPR018019
InterPro IPR018114
InterPro IPR018215
InterPro IPR018992
InterPro IPR021824
InterPro IPR022068
InterPro IPR022120
InterPro IPR022230
InterPro IPR022732
InterPro IPR022764
InterPro IPR023302
InterPro IPR023317
InterPro IPR023662
InterPro IPR024175
InterPro IPR026280
InterPro IPR027065
InterPro IPR027501
InterPro IPR027503
InterPro IPR027543

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0003801 blood coagulation factor activity CONSIDER GO:0004252
GO:0003802 coagulation factor VIIa activity REPLACEDBY GO:0004252
GO:0003803 coagulation factor IXa activity REPLACEDBY GO:0004252
GO:0003804 coagulation factor Xa activity REPLACEDBY GO:0004252
GO:0003805 coagulation factor XIa activity REPLACEDBY GO:0004252
GO:0003806 coagulation factor XIIa activity REPLACEDBY GO:0004252
GO:0003807 plasma kallikrein activity REPLACEDBY GO:0004252
GO:0003808 protein C (activated) activity REPLACEDBY GO:0004252
GO:0003809 thrombin activity REPLACEDBY GO:0004252
GO:0003812 alternative-complement-pathway C3/C5 convertase activity REPLACEDBY GO:0004252
GO:0003813 classical-complement-pathway C3/C5 convertase activity REPLACEDBY GO:0004252
GO:0003815 complement component C1r activity REPLACEDBY GO:0004252
GO:0003816 complement component C1s activity REPLACEDBY GO:0004252
GO:0003817 complement factor D activity REPLACEDBY GO:0004252
GO:0003818 complement factor I activity REPLACEDBY GO:0004252
GO:0004232 interstitial collagenase activity REPLACEDBY GO:0004252
GO:0004253 gamma-renin activity REPLACEDBY GO:0004252
GO:0004254 acylaminoacyl-peptidase activity REPLACEDBY GO:0004252
GO:0004261 cathepsin G activity REPLACEDBY GO:0004252
GO:0004262 cerevisin activity REPLACEDBY GO:0004252
GO:0004263 chymotrypsin activity REPLACEDBY GO:0004252
GO:0004275 enteropeptidase activity REPLACEDBY GO:0004252
GO:0004276 furin activity REPLACEDBY GO:0004252
GO:0004277 granzyme A activity REPLACEDBY GO:0004252
GO:0004278 granzyme B activity REPLACEDBY GO:0004252
GO:0004281 pancreatic elastase II activity REPLACEDBY GO:0004252
GO:0004283 plasmin activity REPLACEDBY GO:0004252
GO:0004284 acrosin activity REPLACEDBY GO:0004252
GO:0004285 proprotein convertase 1 activity REPLACEDBY GO:0004252
GO:0004286 proprotein convertase 2 activity REPLACEDBY GO:0004252
GO:0004287 prolyl oligopeptidase activity REPLACEDBY GO:0004252
GO:0004289 subtilase activity REPLACEDBY GO:0004252
GO:0004290 kexin activity REPLACEDBY GO:0004252
GO:0004291 subtilisin activity REPLACEDBY GO:0004252
GO:0004293 tissue kallikrein activity REPLACEDBY GO:0004252
GO:0004295 trypsin activity REPLACEDBY GO:0004252
GO:0008125 pancreatic elastase I activity REPLACEDBY GO:0004252
GO:0008130 neutrophil collagenase activity REPLACEDBY GO:0004252
GO:0008132 pancreatic elastase activity REPLACEDBY GO:0004252
GO:0008243 plasminogen activator activity REPLACEDBY GO:0004252
GO:0008439 monophenol monooxygenase activator activity REPLACEDBY GO:0004252
GO:0008462 endopeptidase Clp activity REPLACEDBY GO:0004252
GO:0008846 endopeptidase La activity REPLACEDBY GO:0004252
GO:0008931 murein DD-endopeptidase activity REPLACEDBY GO:0004252
GO:0008945 oligopeptidase B activity REPLACEDBY GO:0004252
GO:0008947 omptin activity REPLACEDBY GO:0004252
GO:0008981 protease IV activity REPLACEDBY GO:0004252
GO:0008991 serine-type signal peptidase activity REPLACEDBY GO:0004252
GO:0008992 repressor LexA activity REPLACEDBY GO:0004252
GO:0009004 signal peptidase I activity REPLACEDBY GO:0004252
GO:0016808 proprotein convertase activity REPLACEDBY GO:0004252
GO:0019132 C-terminal processing peptidase activity REPLACEDBY GO:0004252
GO:0030019 tryptase activity REPLACEDBY GO:0004252
GO:0030271 chymase activity REPLACEDBY GO:0004252
GO:0030403 collagenase 4 activity REPLACEDBY GO:0004252
GO:0030404 collagenase 3 activity REPLACEDBY GO:0004252
GO:0051405 microbial collagenase activity REPLACEDBY GO:0004252

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004252:
Relationship To GO:0004252 Child Term Child Term Name
Negatively regulates GO:0004867 serine-type endopeptidase inhibitor activity
Regulates GO:1900003 regulation of serine-type endopeptidase activity
Negatively regulates GO:1900004 negative regulation of serine-type endopeptidase activity
Positively regulates GO:1900005 positive regulation of serine-type endopeptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
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Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Date
Assigned By
Product Form ID
Name
Synonym
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004252. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004252 based on the entire annotation set Co-occurrence statistics for GO:0004252 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-14 Added SYNONYM serine elastase activity
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-04-01 Updated RELATION is a GO:0008236 (serine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
2007-11-08 Deleted SYNONYM serine protease activity
2007-08-09 Added SYNONYM blood coagulation factor activity
2007-08-09 Added SYNONYM serine protease activity
2007-08-09 Deleted SYNONYM blood coagulation factor activity
2007-08-09 Deleted SYNONYM serine protease activity
2007-06-27 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2006-02-09 Added XREF EC:3.4.21
2006-02-09 Deleted XREF EC:3.4.21.-
2005-08-10 Added SYNONYM blood coagulation factor activity
2004-09-11 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a reaction mechanism involving a serine residue (and a histidine residue) at the active center of the enzyme.
2004-04-19 Added SYNONYM serine protease activity
2004-04-16 Deleted SYNONYM serine protease activity
2004-01-08 Added SYNONYM serine protease activity
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active centre of the enzyme.
2003-03-19 Updated TERM serine-type endopeptidase activity
2002-02-06 Updated TERM serine-type endopeptidase
2001-04-03 Updated TERM serine-type endopeptidase
2001-03-30 Added XREF EC:3.4.21.-
2001-03-30 Added TERM serine-type endopeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM serine-type endopeptidase activity
2002-02-06 Updated TERM serine-type endopeptidase
2001-04-03 Updated TERM serine-type endopeptidase
2001-03-30 Added TERM serine-type endopeptidase

Definition/synonyms

Timestamp Action Category Detail
2013-12-14 Added SYNONYM serine elastase activity
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2007-11-08 Deleted SYNONYM serine protease activity
2007-08-09 Added SYNONYM blood coagulation factor activity
2007-08-09 Added SYNONYM serine protease activity
2007-08-09 Deleted SYNONYM blood coagulation factor activity
2007-08-09 Deleted SYNONYM serine protease activity
2007-06-27 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2005-08-10 Added SYNONYM blood coagulation factor activity
2004-09-11 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a reaction mechanism involving a serine residue (and a histidine residue) at the active center of the enzyme.
2004-04-19 Added SYNONYM serine protease activity
2004-04-16 Deleted SYNONYM serine protease activity
2004-01-08 Added SYNONYM serine protease activity
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active centre of the enzyme.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008236 (serine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.21
2006-02-09 Deleted XREF EC:3.4.21.-
2001-03-30 Added XREF EC:3.4.21.-
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