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GO:0004232 interstitial collagenase activity

This term is obsolete.
This term was made obsolete because it represents a gene product.

Term Information

ID GO:0004232
Name interstitial collagenase activity
Ontology Molecular Function
Definition OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
Comment This term was made obsolete because it represents a gene product.
GONUTS GO:0004232 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact MMP-1
exact matrix metalloproteinase 1
exact vertebrate collagenase activity

Replaced by

This term is obsolete - try one of these terms:
Advice GO Identifier Ontology GO Term Name
Replaced by GO:0004252 Molecular Function serine-type endopeptidase activity

Cross-references

Database ID
EC 3.4.24.7
MetaCyc 3.4.24.7-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004232:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004232. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004232 based on the entire annotation set Co-occurrence statistics for GO:0004232 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-08 Deleted RELATION is a GO:0008369 (obsolete molecular function)
2010-06-08 Updated TERM interstitial collagenase activity
2008-11-08 Added OBSOLETION replaced_by GO:0004252 (serine-type endopeptidase activity)
2008-10-21 Deleted OBSOLETION replaced_by GO:0004252 (serine-type endopeptidase activity)
2008-08-18 Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 Deleted DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 Deleted RELATION is a GO:0008133 (collagenase activity)
2008-08-18 Added RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 Added OBSOLETION replaced_by GO:0004252 (serine-type endopeptidase activity)
2008-05-13 Added DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-05-12 Deleted DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-04-01 Updated RELATION is a GO:0008133 (collagenase activity)
2007-11-08 Added SYNONYM vertebrate collagenase activity
2007-08-09 Added SYNONYM MMP-1
2007-08-09 Added SYNONYM matrix metalloproteinase 1
2007-08-09 Deleted SYNONYM MMP-1
2007-08-09 Deleted SYNONYM matrix metalloproteinase 1
2004-04-19 Added SYNONYM MMP-1
2004-04-19 Added SYNONYM matrix metalloproteinase 1
2004-04-16 Deleted SYNONYM MMP-1
2004-04-16 Deleted SYNONYM matrix metalloproteinase 1
2003-10-27 Added SYNONYM MMP-1
2003-10-27 Added SYNONYM matrix metalloproteinase 1
2003-10-27 Added XREF MetaCyc:3.4.24.7-RXN
2003-08-18 Deleted SYNONYM MMP-1
2003-08-18 Deleted SYNONYM matrix metalloproteinase 1
2003-03-19 Updated TERM interstitial collagenase activity
2002-11-27 Added DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2002-02-06 Updated TERM interstitial collagenase
2001-10-01 Added SYNONYM MMP-1
2001-10-01 Added SYNONYM matrix metalloproteinase 1
2001-04-03 Updated TERM interstitial collagenase
2001-03-30 Added XREF EC:3.4.24.7
2001-03-30 Added TERM interstitial collagenase

Term

Timestamp Action Category Detail
2010-06-08 Updated TERM interstitial collagenase activity
2003-03-19 Updated TERM interstitial collagenase activity
2002-02-06 Updated TERM interstitial collagenase
2001-04-03 Updated TERM interstitial collagenase
2001-03-30 Added TERM interstitial collagenase

Obsoletions

Timestamp Action Category Detail
2008-11-08 Added OBSOLETION replaced_by GO:0004252 (serine-type endopeptidase activity)
2008-10-21 Deleted OBSOLETION replaced_by GO:0004252 (serine-type endopeptidase activity)
2008-08-18 Added OBSOLETION replaced_by GO:0004252 (serine-type endopeptidase activity)

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Added DEFINITION OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-08-18 Deleted DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-05-13 Added DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2008-05-12 Deleted DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2007-11-08 Added SYNONYM vertebrate collagenase activity
2007-08-09 Added SYNONYM MMP-1
2007-08-09 Added SYNONYM matrix metalloproteinase 1
2007-08-09 Deleted SYNONYM MMP-1
2007-08-09 Deleted SYNONYM matrix metalloproteinase 1
2004-04-19 Added SYNONYM MMP-1
2004-04-19 Added SYNONYM matrix metalloproteinase 1
2004-04-16 Deleted SYNONYM MMP-1
2004-04-16 Deleted SYNONYM matrix metalloproteinase 1
2003-10-27 Added SYNONYM MMP-1
2003-10-27 Added SYNONYM matrix metalloproteinase 1
2003-08-18 Deleted SYNONYM MMP-1
2003-08-18 Deleted SYNONYM matrix metalloproteinase 1
2002-11-27 Added DEFINITION Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue.
2001-10-01 Added SYNONYM MMP-1
2001-10-01 Added SYNONYM matrix metalloproteinase 1

Relationships

Timestamp Action Category Detail
2010-06-08 Deleted RELATION is a GO:0008369 (obsolete molecular function)
2008-08-18 Deleted RELATION is a GO:0008133 (collagenase activity)
2008-08-18 Added RELATION is a GO:0008369 (obsolete molecular function)
2008-04-01 Updated RELATION is a GO:0008133 (collagenase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:3.4.24.7-RXN
2001-03-30 Added XREF EC:3.4.24.7
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