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GO:0004222 metalloendopeptidase activity

Term Information

ID GO:0004222
Name metalloendopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GONUTS GO:0004222 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact metalloendoproteinase activity
exact metalloendoprotease activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.24
InterPro IPR000013
InterPro IPR000395
InterPro IPR000642
InterPro IPR000718
InterPro IPR000841
InterPro IPR001193
InterPro IPR001384
InterPro IPR001431
InterPro IPR001506
InterPro IPR001567
InterPro IPR001570
InterPro IPR001577
InterPro IPR001590
InterPro IPR001818
InterPro IPR001842
InterPro IPR001915
InterPro IPR002036
InterPro IPR002870
InterPro IPR004387
InterPro IPR004438
InterPro IPR005072
InterPro IPR005936
InterPro IPR006586
InterPro IPR008006
InterPro IPR008294
InterPro IPR008915
InterPro IPR009220
InterPro IPR010294
InterPro IPR011505
InterPro IPR011546
InterPro IPR011844
InterPro IPR012314
InterPro IPR012500
InterPro IPR012928
InterPro IPR013856
InterPro IPR015446
InterPro IPR016293
InterPro IPR016294
InterPro IPR017368
InterPro IPR018497
InterPro IPR019165
InterPro IPR019503
InterPro IPR021158
InterPro IPR021190
InterPro IPR021805
InterPro IPR022450
InterPro IPR022919
InterPro IPR023091
InterPro IPR023612
InterPro IPR027053
InterPro IPR028687
InterPro IPR028688
InterPro IPR028693
InterPro IPR028697
InterPro IPR028700
InterPro IPR028705
InterPro IPR028707
InterPro IPR028708
InterPro IPR028709
InterPro IPR028711
InterPro IPR028716
InterPro IPR028718
InterPro IPR028723
InterPro IPR028726
InterPro IPR028729
InterPro IPR028733
InterPro IPR028735
InterPro IPR028736
InterPro IPR029463
InterPro IPR029727
InterPro IPR029733
InterPro IPR029734
InterPro IPR029735
InterPro IPR029737
InterPro IPR029837
InterPro IPR030433

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004241 alpha-mitochondrial processing peptidase CONSIDER GO:0004222
GO:0004242 beta-mitochondrial processing peptidase CONSIDER GO:0004222
GO:0004228 gelatinase A activity REPLACEDBY GO:0004222
GO:0004229 gelatinase B activity REPLACEDBY GO:0004222
GO:0004231 insulysin activity REPLACEDBY GO:0004222
GO:0004234 macrophage elastase activity REPLACEDBY GO:0004222
GO:0004235 matrilysin activity REPLACEDBY GO:0004222
GO:0004238 meprin A activity REPLACEDBY GO:0004222
GO:0004240 mitochondrial processing peptidase activity REPLACEDBY GO:0004222
GO:0004243 mitochondrial intermediate peptidase activity REPLACEDBY GO:0004222
GO:0004245 neprilysin activity REPLACEDBY GO:0004222
GO:0004247 saccharolysin activity REPLACEDBY GO:0004222
GO:0004248 stromelysin 1 activity REPLACEDBY GO:0004222
GO:0004249 stromelysin 3 activity REPLACEDBY GO:0004222
GO:0008133 collagenase activity REPLACEDBY GO:0004222
GO:0008319 prenyl protein specific endopeptidase activity REPLACEDBY GO:0004222
GO:0008450 O-sialoglycoprotein endopeptidase activity REPLACEDBY GO:0004222
GO:0008487 prenyl-dependent CAAX protease activity REPLACEDBY GO:0004222
GO:0008533 astacin activity REPLACEDBY GO:0004222
GO:0008944 oligopeptidase A activity REPLACEDBY GO:0004222
GO:0008975 pitrilysin activity REPLACEDBY GO:0004222
GO:0016511 endothelin-converting enzyme activity REPLACEDBY GO:0004222
GO:0016512 endothelin-converting enzyme 1 activity REPLACEDBY GO:0004222
GO:0016919 nardilysin activity REPLACEDBY GO:0004222
GO:0017026 procollagen C-endopeptidase activity REPLACEDBY GO:0004222
GO:0017074 procollagen N-endopeptidase activity REPLACEDBY GO:0004222
GO:0030303 stromelysin 2 activity REPLACEDBY GO:0004222
GO:0030402 matrilysin-2 activity REPLACEDBY GO:0004222
GO:0030405 matrix metalloproteinase 19 activity REPLACEDBY GO:0004222
GO:0030406 matrix metalloproteinase 25 activity REPLACEDBY GO:0004222
GO:0033264 bontoxilysin activity REPLACEDBY GO:0004222
GO:0042029 fibrolase activity REPLACEDBY GO:0004222

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004222:
Relationship To GO:0004222 Child Term Child Term Name
Negatively regulates GO:0008191 metalloendopeptidase inhibitor activity
Is a GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Assigned By
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004222. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004222 based on the entire annotation set Co-occurrence statistics for GO:0004222 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-11-23 Deleted SYNONYM metalloprotease
2008-11-23 Deleted SYNONYM metalloproteinase
2008-11-23 Added SYNONYM metalloendoprotease activity
2008-11-23 Added SYNONYM metalloendoproteinase activity
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
2008-04-01 Updated RELATION is a GO:0008237 (metallopeptidase activity)
2007-08-09 Added SYNONYM metalloprotease
2007-08-09 Added SYNONYM metalloproteinase
2007-08-09 Deleted SYNONYM metalloprotease
2007-08-09 Deleted SYNONYM metalloproteinase
2006-02-09 Added XREF EC:3.4.24
2006-02-09 Deleted XREF EC:3.4.24.-
2004-04-19 Added SYNONYM metalloprotease
2004-04-19 Added SYNONYM metalloproteinase
2004-04-16 Deleted SYNONYM metalloprotease
2004-04-16 Deleted SYNONYM metalloproteinase
2003-07-31 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2003-04-12 Updated DEFINITION Enzymes within subclass EC:3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites.
2003-03-19 Updated TERM metalloendopeptidase activity
2002-11-27 Added DEFINITION Enzymes within subclass EC 3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites.
2002-02-06 Updated TERM metalloendopeptidase
2001-08-28 Added SYNONYM metalloprotease
2001-08-28 Added SYNONYM metalloproteinase
2001-04-03 Updated TERM metalloendopeptidase
2001-03-30 Added XREF EC:3.4.24.-
2001-03-30 Added TERM metalloendopeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM metalloendopeptidase activity
2002-02-06 Updated TERM metalloendopeptidase
2001-04-03 Updated TERM metalloendopeptidase
2001-03-30 Added TERM metalloendopeptidase

Definition/synonyms

Timestamp Action Category Detail
2008-11-23 Deleted SYNONYM metalloprotease
2008-11-23 Deleted SYNONYM metalloproteinase
2008-11-23 Added SYNONYM metalloendoprotease activity
2008-11-23 Added SYNONYM metalloendoproteinase activity
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2007-08-09 Added SYNONYM metalloprotease
2007-08-09 Added SYNONYM metalloproteinase
2007-08-09 Deleted SYNONYM metalloprotease
2007-08-09 Deleted SYNONYM metalloproteinase
2004-04-19 Added SYNONYM metalloprotease
2004-04-19 Added SYNONYM metalloproteinase
2004-04-16 Deleted SYNONYM metalloprotease
2004-04-16 Deleted SYNONYM metalloproteinase
2003-07-31 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites.
2003-04-12 Updated DEFINITION Enzymes within subclass EC:3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites.
2002-11-27 Added DEFINITION Enzymes within subclass EC 3.4, peptide hydrolases, that hydrolyze nonterminal peptide linkages in oligopeptides or polypeptides, and that contain a chelated metal ion as an essential catalytic activity at their active sites.
2001-08-28 Added SYNONYM metalloprotease
2001-08-28 Added SYNONYM metalloproteinase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
2008-04-01 Updated RELATION is a GO:0008237 (metallopeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.24
2006-02-09 Deleted XREF EC:3.4.24.-
2001-03-30 Added XREF EC:3.4.24.-
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