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GO:0004221 ubiquitin thiolesterase activityCatalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
Term Information
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| Type | Synonym |
| exact | ubiquitin-C-terminal-thioester hydrolase activity |
| narrow | ubiquitinyl hydrolase 1 activity |
| exact | ubiquitin carboxy-terminal esterase activity |
| exact | ubiquitin thioesterase activity |
| related | ubiquitin C-terminal hydrolase activity |
| related | ubiquitin carboxy-terminal hydrolase activity |
| Database | ID |
| EC | 3.1.2.15 |
| MetaCyc | UBIQUITIN-THIOLESTERASE-RXN |
| INTERPRO | IPR001394 |
| INTERPRO | IPR001578 |
| INTERPRO | IPR018200 |
| INTERPRO | IPR015054 |
| INTERPRO | IPR006615 |
GO:0008581 ubiquitin-specific protease 5 activity |
(replaced_by GO:0004221) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||
![]() | GO:0003824 catalytic activity | ||||
![]() | ![]() | GO:0016787 hydrolase activity | |||
![]() | ![]() | ![]() | GO:0016788 hydrolase activity, acting on ester bonds | ||
![]() | ![]() | ![]() | ![]() | GO:0016790 thiolester hydrolase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | GO:0004221 ubiquitin thiolesterase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-8.ebi.ac.uk |
| Uptime | 17:46 13/10/2009 |
| Data version | 2009-11-21-04-03-45 |