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GO:0004198 calcium-dependent cysteine-type endopeptidase activity

Term Information

ID GO:0004198
Name calcium-dependent cysteine-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
GONUTS GO:0004198 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow calpain activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR001300
InterPro IPR022684
InterPro IPR029531
InterPro IPR029539
InterPro IPR029643

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004198:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004198. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004198 based on the entire annotation set Co-occurrence statistics for GO:0004198 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-04-01 Updated RELATION is a GO:0004197 (cysteine-type endopeptidase activity)
2007-10-25 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2007-09-13 Added SYNONYM calpain activity
2007-09-13 Deleted XREF MetaCyc:3.4.22.17-RXN
2007-09-13 Deleted XREF EC:3.4.22.17
2007-09-13 Updated TERM calcium-dependent cysteine-type endopeptidase activity
2003-10-27 Added XREF MetaCyc:3.4.22.17-RXN
2003-03-19 Updated TERM calpain activity
2002-11-27 Added DEFINITION Catalysis of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.
2002-02-06 Updated TERM calpain
2001-04-03 Updated TERM calpain
2001-03-30 Added XREF EC:3.4.22.17
2001-03-30 Added TERM calpain

Term

Timestamp Action Category Detail
2007-09-13 Updated TERM calcium-dependent cysteine-type endopeptidase activity
2003-03-19 Updated TERM calpain activity
2002-02-06 Updated TERM calpain
2001-04-03 Updated TERM calpain
2001-03-30 Added TERM calpain

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2007-10-25 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.
2007-09-13 Added SYNONYM calpain activity
2002-11-27 Added DEFINITION Catalysis of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004197 (cysteine-type endopeptidase activity)

Cross-references

Timestamp Action Category Detail
2007-09-13 Deleted XREF MetaCyc:3.4.22.17-RXN
2007-09-13 Deleted XREF EC:3.4.22.17
2003-10-27 Added XREF MetaCyc:3.4.22.17-RXN
2001-03-30 Added XREF EC:3.4.22.17
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