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GO:0004197 cysteine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.

Term Information

ID GO:0004197
Name cysteine-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Comment

Synonyms

Type Synonym
exact thiol endopeptidase activity
narrow lysosomal cysteine-type endopeptidase

Cross-references associated with this term:

Database ID
INTERPRO IPR015471
INTERPRO IPR001096
INTERPRO IPR016129
EC 3.4.22
INTERPRO IPR008739
INTERPRO IPR013614
INTERPRO IPR013193
INTERPRO IPR012599
INTERPRO IPR012600
INTERPRO IPR016510
INTERPRO IPR000317
INTERPRO IPR015470
INTERPRO IPR011600
INTERPRO IPR001456
INTERPRO IPR001309
INTERPRO IPR002138
INTERPRO IPR002398
INTERPRO IPR000169
INTERPRO IPR000199
INTERPRO IPR004134
INTERPRO IPR002620
INTERPRO IPR015469
INTERPRO IPR000855
INTERPRO IPR008738
INTERPRO IPR001665
INTERPRO IPR002704
INTERPRO IPR009466
INTERPRO IPR008741
INTERPRO IPR008742
INTERPRO IPR001490
INTERPRO IPR002868
INTERPRO IPR002540
INTERPRO IPR006473
INTERPRO IPR009669

This term can be used instead of these obsolete terms:

GO:0001509 legumain activity (replaced_by GO:0004197)
GO:0004213 cathepsin B activity (replaced_by GO:0004197)
GO:0010320 arginine/lysine endopeptidase activity (replaced_by GO:0004197)
GO:0004212 lysosomal cysteine-type endopeptidase (consider GO:0004197)
GO:0016946 cathepsin F activity (replaced_by GO:0004197)
GO:0030693 caspase activity (replaced_by GO:0004197)
GO:0031079 picornain 3C activity (replaced_by GO:0004197)
GO:0051404 clostripain activity (replaced_by GO:0004197)
GO:0004200 signaling (initiator) caspase activity (replaced_by GO:0004197)
GO:0004201 caspase-1 activity (replaced_by GO:0004197)
GO:0004202 caspase-2 activity (replaced_by GO:0004197)
GO:0004203 caspase-4 activity (replaced_by GO:0004197)
GO:0004204 caspase-5 activity (replaced_by GO:0004197)
GO:0004205 caspase-8 activity (replaced_by GO:0004197)
GO:0004206 caspase-10 activity (replaced_by GO:0004197)
GO:0004207 effector caspase activity (replaced_by GO:0004197)
GO:0004208 caspase-3 activity (replaced_by GO:0004197)
GO:0004209 caspase-6 activity (replaced_by GO:0004197)
GO:0004210 caspase-7 activity (replaced_by GO:0004197)
GO:0004211 caspase-9 activity (replaced_by GO:0004197)
GO:0004215 cathepsin H activity (replaced_by GO:0004197)
GO:0004216 cathepsin K activity (replaced_by GO:0004197)
GO:0004217 cathepsin L activity (replaced_by GO:0004197)
GO:0004218 cathepsin S activity (replaced_by GO:0004197)
GO:0008129 actinidain activity (replaced_by GO:0004197)
GO:0008423 bleomycin hydrolase activity (replaced_by GO:0004197)

Web service: term information

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GTerm?id=termID&format=format

Full details can be found on the QuickGO Web Services page.

Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0070011 peptidase activity, acting on L-amino acid peptides
GO:0004175 endopeptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0004197 cysteine-type endopeptidase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0004198 calcium-dependent cysteine-type endopeptidase activity
I GO:0070137 small conjugating protein-specific endopeptidase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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