spacer

GO:0004197 cysteine-type endopeptidase activity

Term Information

ID GO:0004197
Name cysteine-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
GONUTS GO:0004197 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact thiol endopeptidase activity
narrow caspase activity
narrow metacaspase activity
narrow lysosomal cysteine-type endopeptidase

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.22
InterPro IPR000199
InterPro IPR000317
InterPro IPR000855
InterPro IPR001309
InterPro IPR001456
InterPro IPR001490
InterPro IPR001665
InterPro IPR002138
InterPro IPR002398
InterPro IPR002518
InterPro IPR002540
InterPro IPR002704
InterPro IPR002868
InterPro IPR003951
InterPro IPR004134
InterPro IPR006473
InterPro IPR008043
InterPro IPR008738
InterPro IPR008739
InterPro IPR008741
InterPro IPR009466
InterPro IPR009669
InterPro IPR011600
InterPro IPR012599
InterPro IPR012600
InterPro IPR013614
InterPro IPR014827
InterPro IPR014828
InterPro IPR014829
InterPro IPR014838
InterPro IPR015470
InterPro IPR015471
InterPro IPR016510
InterPro IPR021590
InterPro IPR021824
InterPro IPR021981
InterPro IPR022120
InterPro IPR022230
InterPro IPR022245
InterPro IPR022733
InterPro IPR032915
InterPro IPR032916
InterPro IPR033159
InterPro IPR033165
InterPro IPR033170
InterPro IPR033171
InterPro IPR033174
InterPro IPR033176
InterPro IPR033474
InterPro IPR033476
InterPro IPR033540

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004212 obsolete lysosomal cysteine-type endopeptidase CONSIDER GO:0004197
GO:0010320 obsolete arginine/lysine endopeptidase activity CONSIDER GO:0004197
GO:0001509 obsolete legumain activity REPLACEDBY GO:0004197
GO:0004200 obsolete signaling (initiator) caspase activity REPLACEDBY GO:0004197
GO:0004201 obsolete caspase-1 activity REPLACEDBY GO:0004197
GO:0004202 obsolete caspase-2 activity REPLACEDBY GO:0004197
GO:0004203 obsolete caspase-4 activity REPLACEDBY GO:0004197
GO:0004204 obsolete caspase-5 activity REPLACEDBY GO:0004197
GO:0004205 obsolete caspase-8 activity REPLACEDBY GO:0004197
GO:0004206 obsolete caspase-10 activity REPLACEDBY GO:0004197
GO:0004207 obsolete effector caspase activity REPLACEDBY GO:0004197
GO:0004208 obsolete caspase-3 activity REPLACEDBY GO:0004197
GO:0004209 obsolete caspase-6 activity REPLACEDBY GO:0004197
GO:0004210 obsolete caspase-7 activity REPLACEDBY GO:0004197
GO:0004211 obsolete caspase-9 activity REPLACEDBY GO:0004197
GO:0004213 obsolete cathepsin B activity REPLACEDBY GO:0004197
GO:0004215 obsolete cathepsin H activity REPLACEDBY GO:0004197
GO:0004216 obsolete cathepsin K activity REPLACEDBY GO:0004197
GO:0004217 obsolete cathepsin L activity REPLACEDBY GO:0004197
GO:0004218 obsolete cathepsin S activity REPLACEDBY GO:0004197
GO:0008129 obsolete actinidain activity REPLACEDBY GO:0004197
GO:0008423 obsolete bleomycin hydrolase activity REPLACEDBY GO:0004197
GO:0016946 obsolete cathepsin F activity REPLACEDBY GO:0004197
GO:0030693 obsolete caspase activity REPLACEDBY GO:0004197
GO:0031079 obsolete picornain 3C activity REPLACEDBY GO:0004197
GO:0051404 obsolete clostripain activity REPLACEDBY GO:0004197

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004197:
Relationship To GO:0004197 Child Term Child Term Name
Negatively regulates GO:2000117 negative regulation of cysteine-type endopeptidase activity
Is a GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Regulates GO:2000116 regulation of cysteine-type endopeptidase activity
Is a GO:0070137 ubiquitin-like protein-specific endopeptidase activity
Is a GO:0097299 cysteine-type endopeptidase activity involved in plant-type hypersensitive response
Positively regulates GO:2001056 positive regulation of cysteine-type endopeptidase activity
Is a GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Capable of GO:0008303 caspase complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004197. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004197 based on the entire annotation set Co-occurrence statistics for GO:0004197 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-11-02 Added SYNONYM caspase activity
2011-11-02 Added SYNONYM metacaspase activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-04-01 Updated RELATION is a GO:0008234 (cysteine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
2007-11-08 Added SYNONYM thiol endopeptidase activity
2007-11-08 Deleted SYNONYM thiol endopeptidase
2007-08-09 Added SYNONYM lysosomal cysteine-type endopeptidase
2007-08-09 Added SYNONYM thiol endopeptidase
2007-08-09 Deleted SYNONYM lysosomal cysteine-type endopeptidase
2007-08-09 Deleted SYNONYM thiol endopeptidase
2006-02-09 Added XREF EC:3.4.22
2006-02-09 Deleted XREF EC:3.4.22.-
2005-08-10 Added SYNONYM lysosomal cysteine-type endopeptidase
2004-04-19 Added SYNONYM thiol endopeptidase
2004-04-16 Deleted SYNONYM thiol endopeptidase
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active centre.
2003-03-19 Updated TERM cysteine-type endopeptidase activity
2003-03-19 Deleted SYNONYM thiol protease
2002-11-05 Added SYNONYM thiol endopeptidase
2002-02-06 Updated TERM cysteine-type endopeptidase
2001-04-03 Updated TERM cysteine-type endopeptidase
2001-03-30 Added XREF EC:3.4.22.-
2001-03-30 Added SYNONYM thiol protease
2001-03-30 Added TERM cysteine-type endopeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM cysteine-type endopeptidase activity
2002-02-06 Updated TERM cysteine-type endopeptidase
2001-04-03 Updated TERM cysteine-type endopeptidase
2001-03-30 Added TERM cysteine-type endopeptidase

Definition/synonyms

Timestamp Action Category Detail
2011-11-02 Added SYNONYM caspase activity
2011-11-02 Added SYNONYM metacaspase activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2007-11-08 Added SYNONYM thiol endopeptidase activity
2007-11-08 Deleted SYNONYM thiol endopeptidase
2007-08-09 Added SYNONYM lysosomal cysteine-type endopeptidase
2007-08-09 Added SYNONYM thiol endopeptidase
2007-08-09 Deleted SYNONYM lysosomal cysteine-type endopeptidase
2007-08-09 Deleted SYNONYM thiol endopeptidase
2005-08-10 Added SYNONYM lysosomal cysteine-type endopeptidase
2004-04-19 Added SYNONYM thiol endopeptidase
2004-04-16 Deleted SYNONYM thiol endopeptidase
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active centre.
2003-03-19 Deleted SYNONYM thiol protease
2002-11-05 Added SYNONYM thiol endopeptidase
2001-03-30 Added SYNONYM thiol protease

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008234 (cysteine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.22
2006-02-09 Deleted XREF EC:3.4.22.-
2001-03-30 Added XREF EC:3.4.22.-
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
23ms