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GO:0004190 aspartic-type endopeptidase activity

Term Information

ID GO:0004190
Name aspartic-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
GONUTS GO:0004190 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact aspartate protease activity
exact carboxyl protease activity
exact aspartyl protease activity
exact aspartic protease activity
exact aspartic endopeptidase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.23
InterPro IPR000045
InterPro IPR000250
InterPro IPR000588
InterPro IPR000696
InterPro IPR001108
InterPro IPR001461
InterPro IPR001641
InterPro IPR001872
InterPro IPR001969
InterPro IPR001995
InterPro IPR005081
InterPro IPR006639
InterPro IPR007369
InterPro IPR009119
InterPro IPR009120
InterPro IPR009121
InterPro IPR012848
InterPro IPR019103
InterPro IPR020080
InterPro IPR023619
UniProtKB-KW Aspartyl protease

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004191 barrierpepsin activity REPLACEDBY GO:0004190
GO:0004192 cathepsin D activity REPLACEDBY GO:0004190
GO:0004193 cathepsin E activity REPLACEDBY GO:0004190
GO:0004194 pepsin A activity REPLACEDBY GO:0004190
GO:0004195 renin activity REPLACEDBY GO:0004190
GO:0004196 saccharopepsin activity REPLACEDBY GO:0004190
GO:0008978 prepilin peptidase activity REPLACEDBY GO:0004190
GO:0009005 signal peptidase II activity REPLACEDBY GO:0004190
GO:0009049 aspartic-type signal peptidase activity REPLACEDBY GO:0004190
GO:0030602 chymosin activity REPLACEDBY GO:0004190
GO:0046560 scytalidopepsin B activity REPLACEDBY GO:0004190
GO:0046561 penicillopepsin activity REPLACEDBY GO:0004190

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004190:
Relationship To GO:0004190 Child Term Child Term Name
Is a GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
Negatively regulates GO:0019828 aspartic-type endopeptidase inhibitor activity
Is a GO:1902944 aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004190. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004190 based on the entire annotation set Co-occurrence statistics for GO:0004190 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-11 Added SYNONYM aspartate protease activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-08-18 Added RELATION is a GO:0070001 (aspartic-type peptidase activity)
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)
2007-08-09 Added SYNONYM aspartic endopeptidase activity
2007-08-09 Added SYNONYM aspartic protease activity
2007-08-09 Added SYNONYM aspartyl protease activity
2007-08-09 Added SYNONYM carboxyl protease activity
2007-08-09 Deleted SYNONYM aspartic endopeptidase activity
2007-08-09 Deleted SYNONYM aspartic protease activity
2007-08-09 Deleted SYNONYM aspartyl protease activity
2007-08-09 Deleted SYNONYM carboxyl protease activity
2006-02-09 Added XREF EC:3.4.23
2006-02-09 Deleted XREF EC:3.4.23.-
2004-04-19 Added SYNONYM aspartic endopeptidase activity
2004-04-19 Added SYNONYM aspartic protease activity
2004-04-19 Added SYNONYM aspartyl protease activity
2004-04-19 Added SYNONYM carboxyl protease activity
2004-04-16 Deleted SYNONYM aspartic endopeptidase activity
2004-04-16 Deleted SYNONYM aspartic protease activity
2004-04-16 Deleted SYNONYM aspartyl protease activity
2004-04-16 Deleted SYNONYM carboxyl protease activity
2004-01-08 Added SYNONYM aspartic endopeptidase activity
2004-01-08 Added SYNONYM aspartic protease activity
2004-01-08 Added SYNONYM aspartyl protease activity
2004-01-08 Added SYNONYM carboxyl protease activity
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2003-03-19 Updated TERM aspartic-type endopeptidase activity
2002-02-06 Updated TERM aspartic-type endopeptidase
2001-04-03 Updated TERM aspartic-type endopeptidase
2001-03-30 Added XREF EC:3.4.23.-
2001-03-30 Added TERM aspartic-type endopeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM aspartic-type endopeptidase activity
2002-02-06 Updated TERM aspartic-type endopeptidase
2001-04-03 Updated TERM aspartic-type endopeptidase
2001-03-30 Added TERM aspartic-type endopeptidase

Definition/synonyms

Timestamp Action Category Detail
2012-01-11 Added SYNONYM aspartate protease activity
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.
2007-08-09 Added SYNONYM aspartic endopeptidase activity
2007-08-09 Added SYNONYM aspartic protease activity
2007-08-09 Added SYNONYM aspartyl protease activity
2007-08-09 Added SYNONYM carboxyl protease activity
2007-08-09 Deleted SYNONYM aspartic endopeptidase activity
2007-08-09 Deleted SYNONYM aspartic protease activity
2007-08-09 Deleted SYNONYM aspartyl protease activity
2007-08-09 Deleted SYNONYM carboxyl protease activity
2004-04-19 Added SYNONYM aspartic endopeptidase activity
2004-04-19 Added SYNONYM aspartic protease activity
2004-04-19 Added SYNONYM aspartyl protease activity
2004-04-19 Added SYNONYM carboxyl protease activity
2004-04-16 Deleted SYNONYM aspartic endopeptidase activity
2004-04-16 Deleted SYNONYM aspartic protease activity
2004-04-16 Deleted SYNONYM aspartyl protease activity
2004-04-16 Deleted SYNONYM carboxyl protease activity
2004-01-08 Added SYNONYM aspartic endopeptidase activity
2004-01-08 Added SYNONYM aspartic protease activity
2004-01-08 Added SYNONYM aspartyl protease activity
2004-01-08 Added SYNONYM carboxyl protease activity
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.

Relationships

Timestamp Action Category Detail
2008-08-18 Added RELATION is a GO:0070001 (aspartic-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004175 (endopeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.23
2006-02-09 Deleted XREF EC:3.4.23.-
2001-03-30 Added XREF EC:3.4.23.-
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