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GO:0004190 aspartic-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.

Term Information

ID GO:0004190
Name aspartic-type endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Comment

Synonyms

Type Synonym
exact aspartic endopeptidase activity
exact aspartic protease activity
exact carboxyl protease activity
exact aspartyl protease activity

Cross-references associated with this term:

Database ID
INTERPRO IPR019103
INTERPRO IPR009119
INTERPRO IPR009120
EC 3.4.23
INTERPRO IPR000696
INTERPRO IPR001461
INTERPRO IPR012848
INTERPRO IPR000250
INTERPRO IPR001995
INTERPRO IPR001872
INTERPRO IPR001641
INTERPRO IPR000588
INTERPRO IPR009007
INTERPRO IPR007369
INTERPRO IPR000045
INTERPRO IPR005081
INTERPRO IPR001969

This term can be used instead of these obsolete terms:

GO:0004191 barrierpepsin activity (replaced_by GO:0004190)
GO:0004192 cathepsin D activity (replaced_by GO:0004190)
GO:0004193 cathepsin E activity (replaced_by GO:0004190)
GO:0004194 pepsin A activity (replaced_by GO:0004190)
GO:0004195 renin activity (replaced_by GO:0004190)
GO:0004196 saccharopepsin activity (replaced_by GO:0004190)
GO:0009005 signal peptidase II activity (replaced_by GO:0004190)
GO:0009049 aspartic-type signal peptidase activity (replaced_by GO:0004190)
GO:0030602 chymosin activity (replaced_by GO:0004190)
GO:0046560 scytalidopepsin B activity (replaced_by GO:0004190)
GO:0046561 penicillopepsin activity (replaced_by GO:0004190)
GO:0008978 prepilin peptidase activity (replaced_by GO:0004190)

Web service: term information

Use this URI template to access this data as a service:

GTerm?id=termID&format=format

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0070011 peptidase activity, acting on L-amino acid peptides
GO:0070001 aspartic-type peptidase activity
GO:0004175 endopeptidase activity
GO:0004190 aspartic-type endopeptidase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0042500 aspartic endopeptidase activity, intramembrane cleaving

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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