spacer

GO:0004185 serine-type carboxypeptidase activity

Term Information

ID GO:0004185
Name serine-type carboxypeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
GONUTS GO:0004185 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact serine carboxypeptidase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.16
InterPro IPR000667
InterPro IPR001563
InterPro IPR008442
InterPro IPR015567
InterPro IPR018202

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004258 vacuolar carboxypeptidase Y CONSIDER GO:0004185
GO:0004186 carboxypeptidase C activity REPLACEDBY GO:0004185
GO:0004187 carboxypeptidase D activity REPLACEDBY GO:0004185
GO:0004188 serine-type Pro-X carboxypeptidase activity REPLACEDBY GO:0004185

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004185:
Relationship To GO:0004185 Child Term Child Term Name
Is a GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Is a GO:0071972 peptidoglycan L,D-transpeptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004185. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004185 based on the entire annotation set Co-occurrence statistics for GO:0004185 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-08-18 Updated TERM serine-type carboxypeptidase activity
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Added SYNONYM serine carboxypeptidase activity
2008-08-18 Deleted RELATION is a GO:0008236 (serine-type peptidase activity)
2008-08-18 Added RELATION is a GO:0070008 (serine-type exopeptidase activity)
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-04-01 Updated RELATION is a GO:0008236 (serine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004180 (carboxypeptidase activity)
2007-06-27 Updated DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2006-02-09 Added XREF EC:3.4.16
2006-02-09 Deleted XREF EC:3.4.16.-
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a serine residue is at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a serine residue is at the active centre.
2003-03-19 Updated TERM serine carboxypeptidase activity
2002-02-06 Updated TERM serine carboxypeptidase
2001-04-03 Updated TERM serine carboxypeptidase
2001-03-30 Added XREF EC:3.4.16.-
2001-03-30 Added TERM serine carboxypeptidase

Term

Timestamp Action Category Detail
2008-08-18 Updated TERM serine-type carboxypeptidase activity
2003-03-19 Updated TERM serine carboxypeptidase activity
2002-02-06 Updated TERM serine carboxypeptidase
2001-04-03 Updated TERM serine carboxypeptidase
2001-03-30 Added TERM serine carboxypeptidase

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-08-18 Added SYNONYM serine carboxypeptidase activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2007-06-27 Updated DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
2003-11-26 Updated DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a serine residue is at the active center.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of carboxyl terminal peptide linkages in oligopeptides or polypeptides; a serine residue is at the active centre.

Relationships

Timestamp Action Category Detail
2008-08-18 Deleted RELATION is a GO:0008236 (serine-type peptidase activity)
2008-08-18 Added RELATION is a GO:0070008 (serine-type exopeptidase activity)
2008-04-01 Updated RELATION is a GO:0008236 (serine-type peptidase activity)
2008-04-01 Updated RELATION is a GO:0004180 (carboxypeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.16
2006-02-09 Deleted XREF EC:3.4.16.-
2001-03-30 Added XREF EC:3.4.16.-
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms