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GO:0004181 metallocarboxypeptidase activity

Term Information

ID GO:0004181
Name metallocarboxypeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GONUTS GO:0004181 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.4.17
InterPro IPR000834
InterPro IPR001333
InterPro IPR015567
InterPro IPR017141
InterPro IPR027062

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004182 carboxypeptidase A activity REPLACEDBY GO:0004181
GO:0004183 carboxypeptidase E activity REPLACEDBY GO:0004181
GO:0004184 lysine carboxypeptidase activity REPLACEDBY GO:0004181
GO:0004189 tubulinyl-Tyr carboxypeptidase activity REPLACEDBY GO:0004181
GO:0004226 Gly-X carboxypeptidase activity REPLACEDBY GO:0004181
GO:0008472 metallocarboxypeptidase D activity REPLACEDBY GO:0004181
GO:0031368 Pro-X metallocarboxypeptidase activity REPLACEDBY GO:0004181
GO:0043275 glutamate carboxypeptidase II activity REPLACEDBY GO:0004181
GO:0050424 alanine carboxypeptidase activity REPLACEDBY GO:0004181
GO:0050425 carboxypeptidase B activity REPLACEDBY GO:0004181

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004181:
Relationship To GO:0004181 Child Term Child Term Name
Is a GO:0009046 zinc D-Ala-D-Ala carboxypeptidase activity
Is a GO:0061473 murein tripeptide carboxypeptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004181. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004181 based on the entire annotation set Co-occurrence statistics for GO:0004181 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-04-01 Updated RELATION is a GO:0008235 (metalloexopeptidase activity)
2008-04-01 Updated RELATION is a GO:0004180 (carboxypeptidase activity)
2006-02-09 Added XREF EC:3.4.17
2006-02-09 Deleted XREF EC:3.4.17.-
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2003-03-19 Updated TERM metallocarboxypeptidase activity
2002-02-06 Updated TERM metallocarboxypeptidase
2001-04-03 Updated TERM metallocarboxypeptidase
2001-03-30 Added XREF EC:3.4.17.-
2001-03-30 Added TERM metallocarboxypeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM metallocarboxypeptidase activity
2002-02-06 Updated TERM metallocarboxypeptidase
2001-04-03 Updated TERM metallocarboxypeptidase
2001-03-30 Added TERM metallocarboxypeptidase

Definition/synonyms

Timestamp Action Category Detail
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.
2003-07-31 Added DEFINITION Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008235 (metalloexopeptidase activity)
2008-04-01 Updated RELATION is a GO:0004180 (carboxypeptidase activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3.4.17
2006-02-09 Deleted XREF EC:3.4.17.-
2001-03-30 Added XREF EC:3.4.17.-
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