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GO:0004175 endopeptidase activity

Term Information

ID GO:0004175
Name endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
Secondary IDs GO:0016809
GONUTS GO:0004175 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related elastase activity
narrow proteasome endopeptidase activity
broad proteinase
exact endoprotease activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR000036
InterPro IPR000243
InterPro IPR000426
InterPro IPR016050
InterPro IPR019983
InterPro IPR020079

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004299 proteasome endopeptidase activity CONSIDER GO:0004175
GO:0016025 proteasome endopeptidase regulator CONSIDER GO:0004175
GO:0016026 proteasome endopeptidase core CONSIDER GO:0004175
GO:0004234 macrophage elastase activity REPLACEDBY GO:0004175
GO:0004244 mitochondrial inner membrane peptidase activity REPLACEDBY GO:0004175
GO:0008717 D-alanyl-D-alanine endopeptidase activity REPLACEDBY GO:0004175
GO:0010320 arginine/lysine endopeptidase activity REPLACEDBY GO:0004175
GO:0042708 elastase activity REPLACEDBY GO:0004175

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004175:
Relationship To GO:0004175 Child Term Child Term Name
Is a GO:0004222 metalloendopeptidase activity
Is a GO:0004197 cysteine-type endopeptidase activity
Is a GO:0004298 threonine-type endopeptidase activity
Is a GO:0004190 aspartic-type endopeptidase activity
Negatively regulates GO:0004866 endopeptidase inhibitor activity
Is a GO:0004252 serine-type endopeptidase activity
Positively regulates GO:0010950 positive regulation of endopeptidase activity
Negatively regulates GO:0010951 negative regulation of endopeptidase activity
Regulates GO:0052548 regulation of endopeptidase activity
Positively regulates GO:0061133 endopeptidase activator activity
Regulates GO:0061135 endopeptidase regulator activity
Is a GO:0070007 glutamic-type endopeptidase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004175. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004175 based on the entire annotation set Co-occurrence statistics for GO:0004175 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-14 Added SYNONYM elastase activity
2010-05-16 Deleted SYNONYM proteasome endopeptidase regulator
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)
2007-11-08 Added SYNONYM endoprotease activity
2007-11-08 Deleted SYNONYM endoprotease
2007-10-04 Deleted SYNONYM proteasome endopeptidase core
2007-08-09 Added SYNONYM endoprotease
2007-08-09 Added SYNONYM proteasome endopeptidase activity
2007-08-09 Added SYNONYM proteasome endopeptidase core
2007-08-09 Added SYNONYM proteasome endopeptidase regulator
2007-08-09 Added SYNONYM proteinase
2007-08-09 Deleted SYNONYM endoprotease
2007-08-09 Deleted SYNONYM proteasome endopeptidase activity
2007-08-09 Deleted SYNONYM proteasome endopeptidase core
2007-08-09 Deleted SYNONYM proteasome endopeptidase regulator
2007-08-09 Deleted SYNONYM proteinase
2005-08-10 Added SYNONYM proteasome endopeptidase activity
2005-08-10 Added SYNONYM proteasome endopeptidase core
2005-08-10 Added SYNONYM proteasome endopeptidase regulator
2004-04-19 Added SYNONYM endoprotease
2004-04-19 Added SYNONYM proteinase
2004-04-16 Deleted SYNONYM endoprotease
2004-04-16 Deleted SYNONYM proteinase
2003-08-06 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2003-04-12 Updated DEFINITION Any enzyme within subclass EC:3.4, peptide hydrolases, that hydrolyzes nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2003-03-19 Updated TERM endopeptidase activity
2002-11-27 Updated DEFINITION Any enzyme within subclass EC 3.4, peptide hydrolases, that hydrolyzes nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC 3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2002-02-06 Updated TERM endopeptidase
2001-12-17 Added SECONDARY GO:0016809 (endopeptidase, unknown catalytic mechanism)
2001-08-28 Added SYNONYM proteinase
2001-08-15 Added DEFINITION Any enzyme within subclass EC 3.4, peptide hydrolases, that hydrolyses nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC 3.4.21-99
2001-04-03 Updated TERM endopeptidase
2001-03-30 Added SYNONYM endoprotease
2001-03-30 Added TERM endopeptidase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM endopeptidase activity
2002-02-06 Updated TERM endopeptidase
2001-04-03 Updated TERM endopeptidase
2001-03-30 Added TERM endopeptidase

Definition/synonyms

Timestamp Action Category Detail
2013-12-14 Added SYNONYM elastase activity
2010-05-16 Deleted SYNONYM proteasome endopeptidase regulator
2008-08-18 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2007-11-08 Added SYNONYM endoprotease activity
2007-11-08 Deleted SYNONYM endoprotease
2007-10-04 Deleted SYNONYM proteasome endopeptidase core
2007-08-09 Added SYNONYM endoprotease
2007-08-09 Added SYNONYM proteasome endopeptidase activity
2007-08-09 Added SYNONYM proteasome endopeptidase core
2007-08-09 Added SYNONYM proteasome endopeptidase regulator
2007-08-09 Added SYNONYM proteinase
2007-08-09 Deleted SYNONYM endoprotease
2007-08-09 Deleted SYNONYM proteasome endopeptidase activity
2007-08-09 Deleted SYNONYM proteasome endopeptidase core
2007-08-09 Deleted SYNONYM proteasome endopeptidase regulator
2007-08-09 Deleted SYNONYM proteinase
2005-08-10 Added SYNONYM proteasome endopeptidase activity
2005-08-10 Added SYNONYM proteasome endopeptidase core
2005-08-10 Added SYNONYM proteasome endopeptidase regulator
2004-04-19 Added SYNONYM endoprotease
2004-04-19 Added SYNONYM proteinase
2004-04-16 Deleted SYNONYM endoprotease
2004-04-16 Deleted SYNONYM proteinase
2003-08-06 Updated DEFINITION Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2003-04-12 Updated DEFINITION Any enzyme within subclass EC:3.4, peptide hydrolases, that hydrolyzes nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2002-11-27 Updated DEFINITION Any enzyme within subclass EC 3.4, peptide hydrolases, that hydrolyzes nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC 3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites.
2001-08-28 Added SYNONYM proteinase
2001-08-15 Added DEFINITION Any enzyme within subclass EC 3.4, peptide hydrolases, that hydrolyses nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC 3.4.21-99
2001-03-30 Added SYNONYM endoprotease

Relationships

Timestamp Action Category Detail
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)

Other

Timestamp Action Category Detail
2001-12-17 Added SECONDARY GO:0016809 (endopeptidase, unknown catalytic mechanism)
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