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GO:0004175 endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.

Term Information

ID GO:0004175
Name endopeptidase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
Comment

Synonyms

Type Synonym
related proteasome endopeptidase regulator
narrow proteasome endopeptidase activity
exact endoprotease activity
broad proteinase

Cross-references associated with this term:

Database ID
INTERPRO IPR020079
INTERPRO IPR000036
INTERPRO IPR019983
INTERPRO IPR016050
INTERPRO IPR009180
INTERPRO IPR000243
INTERPRO IPR000426

This term can be used instead of these obsolete terms:

GO:0010320 arginine/lysine endopeptidase activity (replaced_by GO:0004175)
GO:0004299 proteasome endopeptidase activity (consider GO:0004175)
GO:0042708 elastase activity (replaced_by GO:0004175)
GO:0004234 macrophage elastase activity (replaced_by GO:0004175)
GO:0008717 D-alanyl-D-alanine endopeptidase activity (replaced_by GO:0004175)
GO:0016025 proteasome endopeptidase regulator (consider GO:0004175)
GO:0016026 proteasome endopeptidase core (consider GO:0004175)
GO:0004244 mitochondrial inner membrane peptidase activity (replaced_by GO:0004175)

Web service: term information

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Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0070011 peptidase activity, acting on L-amino acid peptides
GO:0004175 endopeptidase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0004222 metalloendopeptidase activity
I GO:0004197 cysteine-type endopeptidase activity
I GO:0004298 threonine-type endopeptidase activity
I GO:0004190 aspartic-type endopeptidase activity
I GO:0004252 serine-type endopeptidase activity
I GO:0070007 glutamic-type endopeptidase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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