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GO:0004171 deoxyhypusine synthase activity

This term is obsolete.
This term was made obsolete because it represents a multistep reaction.

Term Information

ID GO:0004171
Name deoxyhypusine synthase activity
Ontology Molecular Function
Definition OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
Comment This term was made obsolete because it represents a multistep reaction.
GONUTS GO:0004171 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related [eIF-5A]-deoxyhypusine synthase

Replaced by

This term is obsolete - try one of these terms:
Advice GO Identifier Ontology GO Term Name
Replaced by GO:0008612 Biological Process peptidyl-lysine modification to peptidyl-hypusine
Replaced by GO:0034038 Molecular Function deoxyhypusine synthase activity
Replaced by GO:0050983 Biological Process deoxyhypusine biosynthetic process from spermidine

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004171:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004171. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004171 based on the entire annotation set Co-occurrence statistics for GO:0004171 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-08 Updated TERM deoxyhypusine synthase activity
2010-06-08 Deleted RELATION is a GO:0008369 (obsolete molecular function)
2008-06-03 Added OBSOLETION replaced_by GO:0050983 (deoxyhypusine biosynthetic process from spermidine)
2008-06-03 Added OBSOLETION replaced_by GO:0034038 (deoxyhypusine synthase activity)
2008-06-03 Added OBSOLETION replaced_by GO:0008612 (peptidyl-lysine modification to peptidyl-hypusine)
2008-05-13 Added DEFINITION OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2008-05-12 Deleted DEFINITION OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2008-04-01 Updated RELATION is a GO:0008369 (obsolete molecular function)
2007-08-09 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-08-09 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-07-08 Deleted XREF MetaCyc:2.5.1.46-RXN
2004-07-08 Deleted XREF EC:2.5.1.46
2004-07-04 Added XREF MetaCyc:2.5.1.46-RXN
2004-07-04 Added XREF EC:2.5.1.46
2004-06-27 Deleted XREF MetaCyc:2.5.1.46-RXN
2004-06-27 Deleted XREF EC:2.5.1.46
2004-02-27 Updated DEFINITION OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2003-10-27 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2003-10-27 Added XREF MetaCyc:2.5.1.46-RXN
2003-08-18 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2003-08-14 Updated DEFINITION Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2003-04-24 Updated DEFINITION Catalysis of the reaction: (eIF5A-precursor)-lysine + spermidine = (eIF5A-precursor)-deoxyhypusine + propane-1,3-diamine.
2003-03-26 Updated DEFINITION Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2003-03-19 Updated TERM deoxyhypusine synthase activity
2002-11-27 Added DEFINITION Catalysis of the first reaction of hypusine formation on a specific lysine residue of the eukaryotic initiation factor eIF5A; the reaction occurs in four steps: (i) NAD-dependent dehydrogenation of spermidine, (ii) formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme), (iii) transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor, (iv) reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue. Hence the overall reaction is transfer of a 4-aminobutyl group; in the plants, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor.
2002-02-06 Updated TERM deoxyhypusine synthase
2001-10-01 Added XREF EC:2.5.1.46
2001-10-01 Deleted XREF EC:1.1.1.249
2001-10-01 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2001-10-01 Updated TERM deoxyhypusine synthase
2001-04-03 Updated TERM [eIF-5A]-deoxyhypusine synthase
2001-03-30 Added XREF EC:1.1.1.249
2001-03-30 Added TERM [eIF-5A]-deoxyhypusine synthase

Term

Timestamp Action Category Detail
2010-06-08 Updated TERM deoxyhypusine synthase activity
2003-03-19 Updated TERM deoxyhypusine synthase activity
2002-02-06 Updated TERM deoxyhypusine synthase
2001-10-01 Updated TERM deoxyhypusine synthase
2001-04-03 Updated TERM [eIF-5A]-deoxyhypusine synthase
2001-03-30 Added TERM [eIF-5A]-deoxyhypusine synthase

Obsoletions

Timestamp Action Category Detail
2008-06-03 Added OBSOLETION replaced_by GO:0050983 (deoxyhypusine biosynthetic process from spermidine)
2008-06-03 Added OBSOLETION replaced_by GO:0034038 (deoxyhypusine synthase activity)
2008-06-03 Added OBSOLETION replaced_by GO:0008612 (peptidyl-lysine modification to peptidyl-hypusine)

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2008-05-12 Deleted DEFINITION OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2007-08-09 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2007-08-09 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2004-02-27 Updated DEFINITION OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2003-10-27 Added SYNONYM [eIF-5A]-deoxyhypusine synthase
2003-08-18 Deleted SYNONYM [eIF-5A]-deoxyhypusine synthase
2003-08-14 Updated DEFINITION Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2003-04-24 Updated DEFINITION Catalysis of the reaction: (eIF5A-precursor)-lysine + spermidine = (eIF5A-precursor)-deoxyhypusine + propane-1,3-diamine.
2003-03-26 Updated DEFINITION Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.
2002-11-27 Added DEFINITION Catalysis of the first reaction of hypusine formation on a specific lysine residue of the eukaryotic initiation factor eIF5A; the reaction occurs in four steps: (i) NAD-dependent dehydrogenation of spermidine, (ii) formation of an enzyme-imine intermediate by transfer of the 4-aminobutylidene group from dehydrospermidine to the active site lysine residue (Lys329 for the human enzyme), (iii) transfer of the same 4-aminobutylidene group from the enzyme intermediate to the e1F5A precursor, (iv) reduction of the e1F5A-imine intermediate to form a deoxyhypusine residue. Hence the overall reaction is transfer of a 4-aminobutyl group; in the plants, homospermidine can substitute for spermidine and putrescine can substitute for the lysine residue of the eIF5A precursor.
2001-10-01 Added SYNONYM [eIF-5A]-deoxyhypusine synthase

Relationships

Timestamp Action Category Detail
2010-06-08 Deleted RELATION is a GO:0008369 (obsolete molecular function)
2008-04-01 Updated RELATION is a GO:0008369 (obsolete molecular function)

Cross-references

Timestamp Action Category Detail
2004-07-08 Deleted XREF MetaCyc:2.5.1.46-RXN
2004-07-08 Deleted XREF EC:2.5.1.46
2004-07-04 Added XREF MetaCyc:2.5.1.46-RXN
2004-07-04 Added XREF EC:2.5.1.46
2004-06-27 Deleted XREF MetaCyc:2.5.1.46-RXN
2004-06-27 Deleted XREF EC:2.5.1.46
2003-10-27 Added XREF MetaCyc:2.5.1.46-RXN
2001-10-01 Added XREF EC:2.5.1.46
2001-10-01 Deleted XREF EC:1.1.1.249
2001-03-30 Added XREF EC:1.1.1.249
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