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GO:0004148 dihydrolipoyl dehydrogenase activity

Term Information

ID GO:0004148
Name dihydrolipoyl dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
GONUTS GO:0004148 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact dihydrolipoamide dehydrogenase activity
related dihydrolipoamide reduction
related dihydrolipoylprotein reduction
narrow LDP-Glc activity
narrow LDP-Val activity
exact dehydrolipoate dehydrogenase activity
exact diaphorase activity
exact dihydrolipoic dehydrogenase activity
exact dihydrothioctic dehydrogenase activity
related glycine-cleavage system L-protein activity
exact lipoamide dehydrogenase (NADH) activity
exact lipoamide oxidoreductase (NADH) activity
exact lipoamide reductase (NADH) activity
exact lipoamide reductase activity
exact lipoate dehydrogenase activity
exact lipoic acid dehydrogenase activity
exact lipoyl dehydrogenase activity
related E3 component of alpha-ketoacid dehydrogenase complexes activity
related L-protein activity
exact dihydrolipoamide:NAD+ oxidoreductase
exact protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
exact protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.8.1.4
InterPro IPR006258
MetaCyc DIHYDLIPOXN-RXN
RHEA 15048

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006131 dihydrolipoamide reduction CONSIDER GO:0004148
GO:0006132 dihydrolipoylprotein reduction CONSIDER GO:0004148
GO:0009352 dihydrolipoyl dehydrogenase complex CONSIDER GO:0004148

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004148:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004148. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004148 based on the entire annotation set Co-occurrence statistics for GO:0004148 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:15048
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)
2007-12-06 Added SYNONYM dihydrolipoamide:NAD+ oxidoreductase
2007-12-06 Added SYNONYM protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2007-12-06 Added SYNONYM protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2007-10-13 Deleted SYNONYM dihydrolipoyl dehydrogenase complex
2007-09-06 Added SYNONYM lipoic acid dehydrogenase activity
2007-09-06 Added SYNONYM lipoyl dehydrogenase activity
2007-09-06 Added SYNONYM E3 component of alpha-ketoacid dehydrogenase complexes activity
2007-09-06 Added SYNONYM L-protein activity
2007-09-06 Added SYNONYM LDP-Glc activity
2007-09-06 Added SYNONYM LDP-Val activity
2007-09-06 Added SYNONYM dehydrolipoate dehydrogenase activity
2007-09-06 Added SYNONYM diaphorase activity
2007-09-06 Added SYNONYM dihydrolipoic dehydrogenase activity
2007-09-06 Added SYNONYM dihydrothioctic dehydrogenase activity
2007-09-06 Added SYNONYM glycine-cleavage system L-protein activity
2007-09-06 Added SYNONYM lipoamide dehydrogenase (NADH) activity
2007-09-06 Added SYNONYM lipoamide oxidoreductase (NADH) activity
2007-09-06 Added SYNONYM lipoamide reductase (NADH) activity
2007-09-06 Added SYNONYM lipoamide reductase activity
2007-09-06 Added SYNONYM lipoate dehydrogenase activity
2007-08-09 Added SYNONYM dihydrolipoamide dehydrogenase activity
2007-08-09 Added SYNONYM dihydrolipoamide reduction
2007-08-09 Added SYNONYM dihydrolipoyl dehydrogenase complex
2007-08-09 Added SYNONYM dihydrolipoylprotein reduction
2007-08-09 Deleted SYNONYM dihydrolipoamide dehydrogenase activity
2007-08-09 Deleted SYNONYM dihydrolipoamide reduction
2007-08-09 Deleted SYNONYM dihydrolipoyl dehydrogenase complex
2007-08-09 Deleted SYNONYM dihydrolipoylprotein reduction
2005-08-10 Added SYNONYM dihydrolipoylprotein reduction
2005-08-10 Added SYNONYM dihydrolipoamide reduction
2005-08-10 Added SYNONYM dihydrolipoyl dehydrogenase complex
2004-07-07 Updated DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2004-07-03 Updated DEFINITION Catalysis of the reaction: dihydrolipoamide + NAD+ = lipoamide + NADH + H+.
2004-06-24 Updated DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2004-04-19 Added SYNONYM dihydrolipoamide dehydrogenase activity
2004-04-16 Deleted SYNONYM dihydrolipoamide dehydrogenase activity
2004-01-07 Updated TERM dihydrolipoyl dehydrogenase activity
2004-01-07 Added SYNONYM dihydrolipoamide dehydrogenase activity
2003-10-27 Added XREF MetaCyc:DIHYDLIPOXN-RXN
2003-03-19 Updated TERM dihydrolipoamide dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: dihydrolipoamide + NAD+ = lipoamide + NADH + H+.
2002-02-06 Updated TERM dihydrolipoamide dehydrogenase
2001-04-03 Updated TERM dihydrolipoamide dehydrogenase
2001-03-30 Added XREF EC:1.8.1.4
2001-03-30 Added TERM dihydrolipoamide dehydrogenase

Term

Timestamp Action Category Detail
2004-01-07 Updated TERM dihydrolipoyl dehydrogenase activity
2003-03-19 Updated TERM dihydrolipoamide dehydrogenase activity
2002-02-06 Updated TERM dihydrolipoamide dehydrogenase
2001-04-03 Updated TERM dihydrolipoamide dehydrogenase
2001-03-30 Added TERM dihydrolipoamide dehydrogenase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2007-12-06 Added SYNONYM dihydrolipoamide:NAD+ oxidoreductase
2007-12-06 Added SYNONYM protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2007-12-06 Added SYNONYM protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
2007-10-13 Deleted SYNONYM dihydrolipoyl dehydrogenase complex
2007-09-06 Added SYNONYM lipoic acid dehydrogenase activity
2007-09-06 Added SYNONYM lipoyl dehydrogenase activity
2007-09-06 Added SYNONYM E3 component of alpha-ketoacid dehydrogenase complexes activity
2007-09-06 Added SYNONYM L-protein activity
2007-09-06 Added SYNONYM LDP-Glc activity
2007-09-06 Added SYNONYM LDP-Val activity
2007-09-06 Added SYNONYM dehydrolipoate dehydrogenase activity
2007-09-06 Added SYNONYM diaphorase activity
2007-09-06 Added SYNONYM dihydrolipoic dehydrogenase activity
2007-09-06 Added SYNONYM dihydrothioctic dehydrogenase activity
2007-09-06 Added SYNONYM glycine-cleavage system L-protein activity
2007-09-06 Added SYNONYM lipoamide dehydrogenase (NADH) activity
2007-09-06 Added SYNONYM lipoamide oxidoreductase (NADH) activity
2007-09-06 Added SYNONYM lipoamide reductase (NADH) activity
2007-09-06 Added SYNONYM lipoamide reductase activity
2007-09-06 Added SYNONYM lipoate dehydrogenase activity
2007-08-09 Added SYNONYM dihydrolipoamide dehydrogenase activity
2007-08-09 Added SYNONYM dihydrolipoamide reduction
2007-08-09 Added SYNONYM dihydrolipoyl dehydrogenase complex
2007-08-09 Added SYNONYM dihydrolipoylprotein reduction
2007-08-09 Deleted SYNONYM dihydrolipoamide dehydrogenase activity
2007-08-09 Deleted SYNONYM dihydrolipoamide reduction
2007-08-09 Deleted SYNONYM dihydrolipoyl dehydrogenase complex
2007-08-09 Deleted SYNONYM dihydrolipoylprotein reduction
2005-08-10 Added SYNONYM dihydrolipoylprotein reduction
2005-08-10 Added SYNONYM dihydrolipoamide reduction
2005-08-10 Added SYNONYM dihydrolipoyl dehydrogenase complex
2004-07-07 Updated DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2004-07-03 Updated DEFINITION Catalysis of the reaction: dihydrolipoamide + NAD+ = lipoamide + NADH + H+.
2004-06-24 Updated DEFINITION Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.
2004-04-19 Added SYNONYM dihydrolipoamide dehydrogenase activity
2004-04-16 Deleted SYNONYM dihydrolipoamide dehydrogenase activity
2004-01-07 Added SYNONYM dihydrolipoamide dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: dihydrolipoamide + NAD+ = lipoamide + NADH + H+.

Relationships

Timestamp Action Category Detail
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:15048
2003-10-27 Added XREF MetaCyc:DIHYDLIPOXN-RXN
2001-03-30 Added XREF EC:1.8.1.4
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