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GO:0004129 cytochrome-c oxidase activity

Term Information

ID GO:0004129
Name cytochrome-c oxidase activity
Ontology Molecular Function
Definition Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Comment The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
GONUTS GO:0004129 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow caa3-type cytochrome c oxidase
narrow cbb3-type cytochrome c oxidase
related complex IV (mitochondrial electron transport) activity
narrow cytochrome a3 activity
narrow cytochrome aa3 activity
related cytochrome oxidase activity
related warburg's respiratory enzyme activity
exact cytochrome c oxidase activity
exact NADH cytochrome c oxidase
narrow ferrocytochrome c oxidase
narrow ferrocytochrome-c:oxygen oxidoreductase
narrow indophenol oxidase
narrow indophenolase
narrow aa3-type cytochrome c oxidase
narrow ba3-type cytochrome c oxidase

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.9.3.1
InterPro IPR000883
InterPro IPR001349
InterPro IPR002124
InterPro IPR002429
InterPro IPR003177
InterPro IPR003204
InterPro IPR003205
InterPro IPR003213
InterPro IPR004202
InterPro IPR004203
InterPro IPR004204
InterPro IPR004677
InterPro IPR008433
InterPro IPR013833
InterPro IPR014241
InterPro IPR014368
InterPro IPR018507
InterPro IPR021050
InterPro IPR023615
InterPro IPR023616
MetaCyc CYTOCHROME-C-OXIDASE-RXN

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0009481 aa3-type cytochrome c oxidase REPLACEDBY GO:0004129
GO:0009482 ba3-type cytochrome c oxidase REPLACEDBY GO:0004129
GO:0009483 caa3-type cytochrome c oxidase REPLACEDBY GO:0004129
GO:0009485 cbb3-type cytochrome c oxidase REPLACEDBY GO:0004129

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004129:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Qualifier
GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004129. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004129 based on the entire annotation set Co-occurrence statistics for GO:0004129 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-03-07 Added RELATION is a GO:0009055 (electron carrier activity)
2013-02-08 Added SYNONYM cytochrome c oxidase activity
2010-09-03 Added DEFINITION Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
2010-09-03 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2008-04-01 Updated RELATION is a GO:0016676 (oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor)
2008-04-01 Updated RELATION is a GO:0015078 (hydrogen ion transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0015002 (heme-copper terminal oxidase activity)
2007-12-06 Added SYNONYM NADH cytochrome c oxidase
2007-12-06 Added SYNONYM ferrocytochrome c oxidase
2007-12-06 Added SYNONYM ferrocytochrome-c:oxygen oxidoreductase
2007-12-06 Added SYNONYM indophenol oxidase
2007-12-06 Added SYNONYM indophenolase
2007-09-06 Added SYNONYM complex IV (mitochondrial electron transport) activity
2007-09-06 Added SYNONYM cytochrome a3 activity
2007-09-06 Added SYNONYM cytochrome aa3 activity
2007-09-06 Added SYNONYM cytochrome oxidase activity
2007-09-06 Added SYNONYM warburg's respiratory enzyme activity
2007-08-09 Added SYNONYM aa3-type cytochrome c oxidase
2007-08-09 Added SYNONYM ba3-type cytochrome c oxidase
2007-08-09 Added SYNONYM caa3-type cytochrome c oxidase
2007-08-09 Added SYNONYM cbb3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM aa3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM ba3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM caa3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM cbb3-type cytochrome c oxidase
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2007-07-11 Deleted XREF TC:3.D.3.-.-
2005-08-10 Added SYNONYM aa3-type cytochrome c oxidase
2005-08-10 Added SYNONYM ba3-type cytochrome c oxidase
2005-08-10 Added SYNONYM caa3-type cytochrome c oxidase
2005-08-10 Added SYNONYM cbb3-type cytochrome c oxidase
2003-10-27 Added XREF TC:3.D.3.-.-
2003-10-27 Added XREF MetaCyc:CYTOCHROME-C-OXIDASE-RXN
2003-09-09 Updated TERM cytochrome-c oxidase activity
2003-08-21 Deleted XREF TC:3.D.3.-.-
2003-03-19 Updated TERM cytochrome c oxidase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2002-02-06 Updated TERM cytochrome c oxidase
2002-01-08 Updated TERM cytochrome c oxidase
2001-08-06 Added DEFINITION A heme/copper terminal oxidase which uses cytochrome c as electron donor. The number of subunits varies from three in some bacteria to 13 in the mammalian mitochondrion.
2001-04-03 Updated TERM cytochrome-c oxidase
2001-03-30 Added XREF TC:3.D.3.-.-
2001-03-30 Added XREF EC:1.9.3.1
2001-03-30 Added TERM cytochrome-c oxidase

Term

Timestamp Action Category Detail
2003-09-09 Updated TERM cytochrome-c oxidase activity
2003-03-19 Updated TERM cytochrome c oxidase activity
2002-02-06 Updated TERM cytochrome c oxidase
2002-01-08 Updated TERM cytochrome c oxidase
2001-04-03 Updated TERM cytochrome-c oxidase
2001-03-30 Added TERM cytochrome-c oxidase

Definition/synonyms

Timestamp Action Category Detail
2013-02-08 Added SYNONYM cytochrome c oxidase activity
2010-09-03 Added DEFINITION Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
2010-09-03 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2007-12-06 Added SYNONYM NADH cytochrome c oxidase
2007-12-06 Added SYNONYM ferrocytochrome c oxidase
2007-12-06 Added SYNONYM ferrocytochrome-c:oxygen oxidoreductase
2007-12-06 Added SYNONYM indophenol oxidase
2007-12-06 Added SYNONYM indophenolase
2007-09-06 Added SYNONYM complex IV (mitochondrial electron transport) activity
2007-09-06 Added SYNONYM cytochrome a3 activity
2007-09-06 Added SYNONYM cytochrome aa3 activity
2007-09-06 Added SYNONYM cytochrome oxidase activity
2007-09-06 Added SYNONYM warburg's respiratory enzyme activity
2007-08-09 Added SYNONYM aa3-type cytochrome c oxidase
2007-08-09 Added SYNONYM ba3-type cytochrome c oxidase
2007-08-09 Added SYNONYM caa3-type cytochrome c oxidase
2007-08-09 Added SYNONYM cbb3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM aa3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM ba3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM caa3-type cytochrome c oxidase
2007-08-09 Deleted SYNONYM cbb3-type cytochrome c oxidase
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2005-08-10 Added SYNONYM aa3-type cytochrome c oxidase
2005-08-10 Added SYNONYM ba3-type cytochrome c oxidase
2005-08-10 Added SYNONYM caa3-type cytochrome c oxidase
2005-08-10 Added SYNONYM cbb3-type cytochrome c oxidase
2002-11-27 Updated DEFINITION Catalysis of the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.
2001-08-06 Added DEFINITION A heme/copper terminal oxidase which uses cytochrome c as electron donor. The number of subunits varies from three in some bacteria to 13 in the mammalian mitochondrion.

Relationships

Timestamp Action Category Detail
2014-03-07 Added RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016676 (oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor)
2008-04-01 Updated RELATION is a GO:0015078 (hydrogen ion transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0015002 (heme-copper terminal oxidase activity)

Cross-references

Timestamp Action Category Detail
2007-07-11 Deleted XREF TC:3.D.3.-.-
2003-10-27 Added XREF TC:3.D.3.-.-
2003-10-27 Added XREF MetaCyc:CYTOCHROME-C-OXIDASE-RXN
2003-08-21 Deleted XREF TC:3.D.3.-.-
2001-03-30 Added XREF TC:3.D.3.-.-
2001-03-30 Added XREF EC:1.9.3.1
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