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GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H

Term Information

ID GO:0004128
Name cytochrome-b5 reductase activity, acting on NAD(P)H
Ontology Molecular Function
Definition Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
GONUTS GO:0004128 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NADH-cytochrome-b5 reductase activity
exact NADH-ferricytochrome b5 oxidoreductase activity
exact NADH:ferricytochrome-b5 oxidoreductase activity
exact cytochrome b5 reductase activity
exact dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
exact reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity
exact NADH 5alpha-reductase activity
exact NADH-cytochrome b5 reductase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.6.2.2
InterPro IPR033566
MetaCyc CYTOCHROME-B5-REDUCTASE-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004128:
Relationship To GO:0004128 Child Term Child Term Name
Is a GO:0090523 cytochrome-b5 reductase activity, acting on NADPH
Is a GO:0090524 cytochrome-b5 reductase activity, acting on NADH

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004128. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004128 based on the entire annotation set Co-occurrence statistics for GO:0004128 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-01-13 Updated TERM cytochrome-b5 reductase activity, acting on NAD(P)H
2013-01-13 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2013-01-13 Added DEFINITION Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2008-04-01 Updated RELATION is a GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2007-11-08 Added SYNONYM NADH 5alpha-reductase activity
2007-11-08 Added SYNONYM NADH-cytochrome b5 reductase activity
2007-11-08 Added SYNONYM NADH-cytochrome-b5 reductase activity
2007-11-08 Added SYNONYM NADH-ferricytochrome b5 oxidoreductase activity
2007-11-08 Added SYNONYM NADH:ferricytochrome-b5 oxidoreductase activity
2007-11-08 Added SYNONYM cytochrome b5 reductase activity
2007-11-08 Added SYNONYM dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
2007-11-08 Added SYNONYM reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity
2003-10-27 Added XREF MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
2003-09-09 Updated TERM cytochrome-b5 reductase activity
2003-04-24 Updated DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2003-03-19 Updated TERM cytochrome b5 reductase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b[5] = NAD+ + 2 ferrocytochrome b[5].
2002-02-06 Updated TERM cytochrome b5 reductase
2001-08-06 Added DEFINITION A flavoprotein enzyme that catalyzes the reaction: NADH + 2 ferricytochrome b[5] = NAD[+] + 2 ferrocytochrome b[5].
2001-04-03 Updated TERM cytochrome b5 reductase
2001-03-30 Added XREF EC:1.6.2.2
2001-03-30 Added TERM cytochrome b5 reductase

Term

Timestamp Action Category Detail
2013-01-13 Updated TERM cytochrome-b5 reductase activity, acting on NAD(P)H
2003-09-09 Updated TERM cytochrome-b5 reductase activity
2003-03-19 Updated TERM cytochrome b5 reductase activity
2002-02-06 Updated TERM cytochrome b5 reductase
2001-04-03 Updated TERM cytochrome b5 reductase
2001-03-30 Added TERM cytochrome b5 reductase

Definition/synonyms

Timestamp Action Category Detail
2013-01-13 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2013-01-13 Added DEFINITION Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2007-11-08 Added SYNONYM NADH 5alpha-reductase activity
2007-11-08 Added SYNONYM NADH-cytochrome b5 reductase activity
2007-11-08 Added SYNONYM NADH-cytochrome-b5 reductase activity
2007-11-08 Added SYNONYM NADH-ferricytochrome b5 oxidoreductase activity
2007-11-08 Added SYNONYM NADH:ferricytochrome-b5 oxidoreductase activity
2007-11-08 Added SYNONYM cytochrome b5 reductase activity
2007-11-08 Added SYNONYM dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity
2007-11-08 Added SYNONYM reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity
2003-04-24 Updated DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).
2002-11-27 Updated DEFINITION Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b[5] = NAD+ + 2 ferrocytochrome b[5].
2001-08-06 Added DEFINITION A flavoprotein enzyme that catalyzes the reaction: NADH + 2 ferricytochrome b[5] = NAD[+] + 2 ferrocytochrome b[5].

Relationships

Timestamp Action Category Detail
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
2001-03-30 Added XREF EC:1.6.2.2
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