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GO:0004122 cystathionine beta-synthase activity

Term Information

ID GO:0004122
Name cystathionine beta-synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
GONUTS GO:0004122 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
exact L-serine hydro-lyase (adding homocysteine)
exact serine sulfhydrylase activity
exact methylcysteine synthase activity
exact beta-thionase activity
exact serine sulfhydrase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 4.2.1.22
InterPro IPR005857
MetaCyc CYSTATHIONINE-BETA-SYNTHASE-RXN
RHEA 10115

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004122:
Term has no children

Protein Annotation

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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004122. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004122 based on the entire annotation set Co-occurrence statistics for GO:0004122 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:10115
2008-05-13 Added DEFINITION Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
2008-04-01 Updated RELATION is a GO:0016836 (hydro-lyase activity)
2007-11-08 Added SYNONYM L-serine hydro-lyase (adding homocysteine)
2007-11-08 Added SYNONYM L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
2007-11-08 Added SYNONYM serine sulfhydrylase activity
2007-09-06 Added SYNONYM beta-thionase activity
2007-09-06 Added SYNONYM methylcysteine synthase activity
2007-09-06 Added SYNONYM serine sulfhydrase activity
2003-10-27 Added XREF MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
2003-09-09 Updated TERM cystathionine beta-synthase activity
2003-03-26 Updated DEFINITION Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
2003-03-19 Updated TERM cystathione beta-synthase activity
2002-11-27 Updated DEFINITION Catalysis the first step of the transsulfuration pathway, the conversion of homocysteine to cystathione.
2002-02-06 Updated TERM cystathione beta-synthase
2001-08-06 Added DEFINITION Catalyses the first step of the transsulfuration pathway, the conversion of homocysteine to cystathione.
2001-04-03 Updated TERM cystathione beta-synthase
2001-03-30 Added XREF EC:4.2.1.22
2001-03-30 Added TERM cystathione beta-synthase

Term

Timestamp Action Category Detail
2003-09-09 Updated TERM cystathionine beta-synthase activity
2003-03-19 Updated TERM cystathione beta-synthase activity
2002-02-06 Updated TERM cystathione beta-synthase
2001-04-03 Updated TERM cystathione beta-synthase
2001-03-30 Added TERM cystathione beta-synthase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
2007-11-08 Added SYNONYM L-serine hydro-lyase (adding homocysteine)
2007-11-08 Added SYNONYM L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
2007-11-08 Added SYNONYM serine sulfhydrylase activity
2007-09-06 Added SYNONYM beta-thionase activity
2007-09-06 Added SYNONYM methylcysteine synthase activity
2007-09-06 Added SYNONYM serine sulfhydrase activity
2003-03-26 Updated DEFINITION Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.
2002-11-27 Updated DEFINITION Catalysis the first step of the transsulfuration pathway, the conversion of homocysteine to cystathione.
2001-08-06 Added DEFINITION Catalyses the first step of the transsulfuration pathway, the conversion of homocysteine to cystathione.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016836 (hydro-lyase activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:10115
2003-10-27 Added XREF MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
2001-03-30 Added XREF EC:4.2.1.22
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