spacer

GO:0004108 citrate (Si)-synthase activity

Term Information

ID GO:0004108
Name citrate (Si)-synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
Comment Note that this function was formerly EC:4.1.3.7.
GONUTS GO:0004108 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
exact citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
related acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
broad condensing enzyme activity
exact citrogenase activity
exact citric-condensing enzyme activity
exact citric synthase activity
exact citrate synthetase activity
broad citrate synthase activity
exact citrate oxaloacetate-lyase, CoA-acetylating activity
exact citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
exact citrate condensing enzyme activity
exact (R)-citric synthase activity
exact oxaloacetate transacetase activity
exact oxalacetic transacetase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.3.3.1
InterPro IPR010109
InterPro IPR010953
MetaCyc CITSYN-RXN

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004108:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004108. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004108 based on the entire annotation set Co-occurrence statistics for GO:0004108 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-10-02 Deleted XREF RHEA:16848
2013-10-02 Added RELATION is a GO:0036440 (citrate synthase activity)
2013-10-02 Deleted RELATION is a GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
2011-09-16 Added XREF RHEA:16848
2009-03-29 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2009-03-29 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2008-04-01 Updated RELATION is a GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
2007-11-08 Added SYNONYM acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
2007-11-08 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
2007-11-08 Added SYNONYM citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
2007-09-06 Added SYNONYM (R)-citric synthase activity
2007-09-06 Added SYNONYM citrate condensing enzyme activity
2007-09-06 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
2007-09-06 Added SYNONYM citrate oxaloacetate-lyase, CoA-acetylating activity
2007-09-06 Added SYNONYM citrate synthase activity
2007-09-06 Added SYNONYM citrate synthetase activity
2007-09-06 Added SYNONYM citric synthase activity
2007-09-06 Added SYNONYM citric-condensing enzyme activity
2007-09-06 Added SYNONYM citrogenase activity
2007-09-06 Added SYNONYM condensing enzyme activity
2007-09-06 Added SYNONYM oxalacetic transacetase activity
2007-09-06 Added SYNONYM oxaloacetate transacetase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2003-10-27 Added XREF MetaCyc:CITSYN-RXN
2003-09-06 Updated TERM citrate (Si)-synthase activity
2003-09-05 Added XREF EC:2.3.3.1
2003-09-05 Deleted XREF EC:4.1.3.7
2003-03-19 Updated TERM citrate (SI)-synthase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: citrate + CoA = acetyl-CoA + H2O + oxaloacetate.
2002-02-06 Updated TERM citrate (SI)-synthase
2001-04-03 Updated TERM citrate (SI)-synthase
2001-03-30 Added XREF EC:4.1.3.7
2001-03-30 Added TERM citrate (SI)-synthase

Term

Timestamp Action Category Detail
2003-09-06 Updated TERM citrate (Si)-synthase activity
2003-03-19 Updated TERM citrate (SI)-synthase activity
2002-02-06 Updated TERM citrate (SI)-synthase
2001-04-03 Updated TERM citrate (SI)-synthase
2001-03-30 Added TERM citrate (SI)-synthase

Definition/synonyms

Timestamp Action Category Detail
2009-03-29 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2009-03-29 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.
2008-05-13 Added DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2007-11-08 Added SYNONYM acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]
2007-11-08 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)
2007-11-08 Added SYNONYM citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]
2007-09-06 Added SYNONYM (R)-citric synthase activity
2007-09-06 Added SYNONYM citrate condensing enzyme activity
2007-09-06 Added SYNONYM citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity
2007-09-06 Added SYNONYM citrate oxaloacetate-lyase, CoA-acetylating activity
2007-09-06 Added SYNONYM citrate synthase activity
2007-09-06 Added SYNONYM citrate synthetase activity
2007-09-06 Added SYNONYM citric synthase activity
2007-09-06 Added SYNONYM citric-condensing enzyme activity
2007-09-06 Added SYNONYM citrogenase activity
2007-09-06 Added SYNONYM condensing enzyme activity
2007-09-06 Added SYNONYM oxalacetic transacetase activity
2007-09-06 Added SYNONYM oxaloacetate transacetase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
2002-11-27 Added DEFINITION Catalysis of the reaction: citrate + CoA = acetyl-CoA + H2O + oxaloacetate.

Relationships

Timestamp Action Category Detail
2013-10-02 Added RELATION is a GO:0036440 (citrate synthase activity)
2013-10-02 Deleted RELATION is a GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
2008-04-01 Updated RELATION is a GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)

Cross-references

Timestamp Action Category Detail
2013-10-02 Deleted XREF RHEA:16848
2011-09-16 Added XREF RHEA:16848
2003-10-27 Added XREF MetaCyc:CITSYN-RXN
2003-09-05 Added XREF EC:2.3.3.1
2003-09-05 Deleted XREF EC:4.1.3.7
2001-03-30 Added XREF EC:4.1.3.7
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
28ms