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GO:0004012 phospholipid-translocating ATPase activity

Term Information

ID GO:0004012
Name phospholipid-translocating ATPase activity
Ontology Molecular Function
Definition Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
PMID:15919184 PMID:9099684
Secondary IDs GO:0008557
GONUTS GO:0004012 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related magnesium-ATPase activity
exact phospolipid flippase activity
related aminophospholipid-transporting ATPase
exact phospholipid-transporting ATPase activity
broad flippase activity
related Mg(2+)-ATPase activity
exact phospholipid translocating ATPase activity
exact Mg2+-ATPase activity
exact ATP phosphohydrolase (phospholipid-flipping)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.6.3.1
InterPro IPR006539
InterPro IPR026871
InterPro IPR030342
InterPro IPR030344
InterPro IPR030346
InterPro IPR030363
MetaCyc 3.6.3.1-RXN
RHEA 14992

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004012:
Relationship To GO:0004012 Child Term Child Term Name
Is a GO:0090554 phosphatidylcholine-translocating ATPase activity
Is a GO:0090555 phosphatidylethanolamine-translocating ATPase activity
Is a GO:0090556 phosphatidylserine-translocating ATPase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004012. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004012 based on the entire annotation set Co-occurrence statistics for GO:0004012 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-11-14 Deleted SYNONYM aminophospholipid-transporting ATPase
2013-11-14 Added SYNONYM aminophospholipid-transporting ATPase
2013-10-30 Added RELATION part of GO:0045332 (phospholipid translocation)
2013-10-26 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2013-10-26 Added DEFINITION Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
2013-10-26 Added SYNONYM phospolipid flippase activity
2011-09-16 Added XREF RHEA:14992
2010-10-31 Added DEFINITION Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2010-10-31 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2010-05-13 Added RELATION is a GO:0005548 (phospholipid transporter activity)
2010-05-13 Deleted RELATION is a GO:0015247 (aminophospholipid transporter activity)
2009-02-05 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospholipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-05 Added DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-01 Added DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospholipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-01 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2008-05-13 Added DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2008-05-12 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2008-04-01 Updated RELATION is a GO:0043492 (ATPase activity, coupled to movement of substances)
2008-04-01 Updated RELATION is a GO:0015247 (aminophospholipid transporter activity)
2007-11-08 Added SYNONYM ATP phosphohydrolase (phospholipid-flipping)
2007-11-08 Added SYNONYM Mg2+-ATPase activity
2007-09-06 Added SYNONYM Mg(2+)-ATPase activity
2007-09-06 Added SYNONYM flippase activity
2007-09-06 Added SYNONYM magnesium-ATPase activity
2007-09-06 Added SYNONYM phospholipid-transporting ATPase activity
2007-09-06 Deleted SYNONYM flippase
2007-09-06 Deleted SYNONYM magnesium-ATPase
2007-08-09 Added SYNONYM phospholipid translocating ATPase activity
2007-08-09 Added SYNONYM aminophospholipid-transporting ATPase
2007-08-09 Added SYNONYM flippase
2007-08-09 Added SYNONYM magnesium-ATPase
2007-08-09 Deleted SYNONYM aminophospholipid-transporting ATPase
2007-08-09 Deleted SYNONYM flippase
2007-08-09 Deleted SYNONYM magnesium-ATPase
2007-08-09 Deleted SYNONYM phospholipid translocating ATPase activity
2005-07-29 Added SYNONYM phospholipid translocating ATPase activity
2004-04-19 Added SYNONYM aminophospholipid-transporting ATPase
2004-04-19 Added SYNONYM flippase
2004-04-19 Added SYNONYM magnesium-ATPase
2004-04-16 Deleted SYNONYM aminophospholipid-transporting ATPase
2004-04-16 Deleted SYNONYM flippase
2004-04-05 Deleted SYNONYM magnesium-ATPase
2003-10-27 Added SYNONYM aminophospholipid-transporting ATPase
2003-10-27 Added SYNONYM flippase
2003-10-27 Added SYNONYM magnesium-ATPase
2003-10-27 Added XREF MetaCyc:3.6.3.1-RXN
2003-08-21 Deleted SYNONYM aminophospholipid-transporting ATPase
2003-08-21 Deleted SYNONYM flippase
2003-08-21 Deleted SYNONYM magnesium-ATPase
2003-03-19 Updated TERM phospholipid-translocating ATPase activity
2002-11-27 Updated DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2002-02-06 Updated TERM phospholipid-translocating ATPase
2001-10-01 Added SECONDARY GO:0008557 (aminophospholipid-transporting ATPase)
2001-10-01 Added SYNONYM aminophospholipid-transporting ATPase
2001-10-01 Added SYNONYM flippase
2001-10-01 Added SYNONYM magnesium-ATPase
2001-10-01 Updated TERM phospholipid-translocating ATPase
2001-08-06 Added DEFINITION A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme apparently has several activities, one of them being the movement of phospholipids from one membrane face to the other ('flippase').
2001-04-03 Updated TERM magnesium-ATPase
2001-03-30 Added XREF EC:3.6.3.1
2001-03-30 Added TERM magnesium-ATPase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM phospholipid-translocating ATPase activity
2002-02-06 Updated TERM phospholipid-translocating ATPase
2001-10-01 Updated TERM phospholipid-translocating ATPase
2001-04-03 Updated TERM magnesium-ATPase
2001-03-30 Added TERM magnesium-ATPase

Definition/synonyms

Timestamp Action Category Detail
2013-11-14 Deleted SYNONYM aminophospholipid-transporting ATPase
2013-11-14 Added SYNONYM aminophospholipid-transporting ATPase
2013-10-26 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2013-10-26 Added DEFINITION Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP.
2013-10-26 Added SYNONYM phospolipid flippase activity
2010-10-31 Added DEFINITION Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2010-10-31 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-05 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospholipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-05 Added DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-01 Added DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other (phospholipid 'flippase' activity), driven by the hydrolysis of ATP.
2009-02-01 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2008-05-13 Added DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2008-05-12 Deleted DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2007-11-08 Added SYNONYM ATP phosphohydrolase (phospholipid-flipping)
2007-11-08 Added SYNONYM Mg2+-ATPase activity
2007-09-06 Added SYNONYM Mg(2+)-ATPase activity
2007-09-06 Added SYNONYM flippase activity
2007-09-06 Added SYNONYM magnesium-ATPase activity
2007-09-06 Added SYNONYM phospholipid-transporting ATPase activity
2007-09-06 Deleted SYNONYM flippase
2007-09-06 Deleted SYNONYM magnesium-ATPase
2007-08-09 Added SYNONYM phospholipid translocating ATPase activity
2007-08-09 Added SYNONYM aminophospholipid-transporting ATPase
2007-08-09 Added SYNONYM flippase
2007-08-09 Added SYNONYM magnesium-ATPase
2007-08-09 Deleted SYNONYM aminophospholipid-transporting ATPase
2007-08-09 Deleted SYNONYM flippase
2007-08-09 Deleted SYNONYM magnesium-ATPase
2007-08-09 Deleted SYNONYM phospholipid translocating ATPase activity
2005-07-29 Added SYNONYM phospholipid translocating ATPase activity
2004-04-19 Added SYNONYM aminophospholipid-transporting ATPase
2004-04-19 Added SYNONYM flippase
2004-04-19 Added SYNONYM magnesium-ATPase
2004-04-16 Deleted SYNONYM aminophospholipid-transporting ATPase
2004-04-16 Deleted SYNONYM flippase
2004-04-05 Deleted SYNONYM magnesium-ATPase
2003-10-27 Added SYNONYM aminophospholipid-transporting ATPase
2003-10-27 Added SYNONYM flippase
2003-10-27 Added SYNONYM magnesium-ATPase
2003-08-21 Deleted SYNONYM aminophospholipid-transporting ATPase
2003-08-21 Deleted SYNONYM flippase
2003-08-21 Deleted SYNONYM magnesium-ATPase
2002-11-27 Updated DEFINITION Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP.
2001-10-01 Added SYNONYM aminophospholipid-transporting ATPase
2001-10-01 Added SYNONYM flippase
2001-10-01 Added SYNONYM magnesium-ATPase
2001-08-06 Added DEFINITION A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme apparently has several activities, one of them being the movement of phospholipids from one membrane face to the other ('flippase').

Relationships

Timestamp Action Category Detail
2013-10-30 Added RELATION part of GO:0045332 (phospholipid translocation)
2010-05-13 Added RELATION is a GO:0005548 (phospholipid transporter activity)
2010-05-13 Deleted RELATION is a GO:0015247 (aminophospholipid transporter activity)
2008-04-01 Updated RELATION is a GO:0043492 (ATPase activity, coupled to movement of substances)
2008-04-01 Updated RELATION is a GO:0015247 (aminophospholipid transporter activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:14992
2003-10-27 Added XREF MetaCyc:3.6.3.1-RXN
2001-03-30 Added XREF EC:3.6.3.1

Other

Timestamp Action Category Detail
2001-10-01 Added SECONDARY GO:0008557 (aminophospholipid-transporting ATPase)
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