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GO:0003958 NADPH-hemoprotein reductase activity

Term Information

ID GO:0003958
Name NADPH-hemoprotein reductase activity
Ontology Molecular Function
Definition Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
GONUTS GO:0003958 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NADPH-ferrihemoprotein reductase activity
narrow cytochrome P450 reductase activity
narrow cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
narrow dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
exact NADPH-cytochrome P-450 oxidoreductase activity
exact NADPH-cytochrome p-450 reductase activity
exact NADPH:P-450 reductase activity
exact NADPH:cytochrome P450 reductase activity
exact NADPH:cytochrome c reductase activity
exact NADPH:hemoprotein oxidoreductase activity
related POR
exact TPNH2 cytochrome c reductase activity
exact cytochrome P-450 reductase activity
related ferrihemoprotein P-450 reductase activity
narrow reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
narrow reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
related CPR activity
related FAD-cytochrome c reductase activity
narrow NADP--cytochrome c reductase activity
narrow NADP--cytochrome reductase activity
narrow NADPH--cytochrome P450 oxidoreductase activity
narrow NADPH--cytochrome P450 reductase activity
narrow NADPH--cytochrome c oxidoreductase activity
narrow NADPH--cytochrome c reductase activity
narrow NADPH--ferricytochrome c oxidoreductase activity
narrow NADPH--ferrihemoprotein reductase activity
narrow NADPH-dependent cytochrome c reductase activity
narrow NADPH:P450 reductase activity
exact NADPH:ferrihemoprotein oxidoreductase activity
narrow TPNH(2) cytochrome c reductase activity
narrow TPNH-cytochrome c reductase activity
related aldehyde reductase (NADPH-dependent) activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.6.2.4
InterPro IPR023206
InterPro IPR023208
InterPro IPR028879
MetaCyc NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003958:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003958. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003958 based on the entire annotation set Co-occurrence statistics for GO:0003958 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)
2007-11-08 Deleted SYNONYM NADPH:cytochrome P450 reductase
2007-11-08 Deleted SYNONYM NADPH:cytochrome c reductase
2007-11-08 Added SYNONYM NADPH-cytochrome P-450 oxidoreductase activity
2007-11-08 Added SYNONYM NADPH-cytochrome p-450 reductase activity
2007-11-08 Added SYNONYM NADPH:P-450 reductase activity
2007-11-08 Added SYNONYM NADPH:cytochrome P450 reductase activity
2007-11-08 Added SYNONYM NADPH:cytochrome c reductase activity
2007-11-08 Added SYNONYM NADPH:hemoprotein oxidoreductase activity
2007-11-08 Added SYNONYM POR
2007-11-08 Added SYNONYM TPNH2 cytochrome c reductase activity
2007-11-08 Added SYNONYM cytochrome P-450 reductase activity
2007-09-06 Added SYNONYM cytochrome P450 reductase activity
2007-09-06 Added SYNONYM cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
2007-09-06 Added SYNONYM dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
2007-09-06 Added SYNONYM ferrihemoprotein P-450 reductase activity
2007-09-06 Added SYNONYM reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
2007-09-06 Added SYNONYM reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
2007-09-06 Added SYNONYM CPR activity
2007-09-06 Added SYNONYM FAD-cytochrome c reductase activity
2007-09-06 Added SYNONYM NADP--cytochrome c reductase activity
2007-09-06 Added SYNONYM NADP--cytochrome reductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome P450 oxidoreductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome P450 reductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome c reductase activity
2007-09-06 Added SYNONYM NADPH--ferricytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM NADPH--ferrihemoprotein reductase activity
2007-09-06 Added SYNONYM NADPH-dependent cytochrome c reductase activity
2007-09-06 Added SYNONYM NADPH:P450 reductase activity
2007-09-06 Added SYNONYM NADPH:ferrihemoprotein oxidoreductase activity
2007-09-06 Added SYNONYM TPNH(2) cytochrome c reductase activity
2007-09-06 Added SYNONYM TPNH-cytochrome c reductase activity
2007-09-06 Added SYNONYM aldehyde reductase (NADPH-dependent) activity
2007-08-09 Added SYNONYM NADPH-ferrihemoprotein reductase activity
2007-08-09 Added SYNONYM NADPH:cytochrome P450 reductase
2007-08-09 Added SYNONYM NADPH:cytochrome c reductase
2007-08-09 Deleted SYNONYM NADPH-ferrihemoprotein reductase activity
2007-08-09 Deleted SYNONYM NADPH:cytochrome P450 reductase
2007-08-09 Deleted SYNONYM NADPH:cytochrome c reductase
2006-02-04 Updated DEFINITION Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
2004-04-19 Added SYNONYM NADPH-ferrihemoprotein reductase activity
2004-04-19 Added SYNONYM NADPH:cytochrome P450 reductase
2004-04-19 Added SYNONYM NADPH:cytochrome c reductase
2004-04-16 Deleted SYNONYM NADPH-ferrihemoprotein reductase activity
2004-04-16 Deleted SYNONYM NADPH:cytochrome P450 reductase
2004-04-16 Deleted SYNONYM NADPH:cytochrome c reductase
2004-01-07 Updated TERM NADPH-hemoprotein reductase activity
2004-01-07 Added SYNONYM NADPH-ferrihemoprotein reductase activity
2003-10-27 Added SYNONYM NADPH:cytochrome P450 reductase
2003-10-27 Added SYNONYM NADPH:cytochrome c reductase
2003-10-27 Added XREF MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
2003-08-21 Deleted SYNONYM NADPH:cytochrome P450 reductase
2003-08-21 Deleted SYNONYM NADPH:cytochrome c reductase
2003-03-19 Updated TERM NADPH-ferrihemoprotein reductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome = NADP+ + 2 ferrocytochrome.
2002-02-06 Updated TERM NADPH-ferrihemoprotein reductase
2001-11-07 Updated TERM NADPH-ferrihemoprotein reductase
2001-04-03 Updated TERM NADPH--ferrihemoprotein reductase
2001-03-30 Added XREF EC:1.6.2.4
2001-03-30 Added SYNONYM NADPH:cytochrome P450 reductase
2001-03-30 Added SYNONYM NADPH:cytochrome c reductase
2001-03-30 Added TERM NADPH--ferrihemoprotein reductase

Term

Timestamp Action Category Detail
2004-01-07 Updated TERM NADPH-hemoprotein reductase activity
2003-03-19 Updated TERM NADPH-ferrihemoprotein reductase activity
2002-02-06 Updated TERM NADPH-ferrihemoprotein reductase
2001-11-07 Updated TERM NADPH-ferrihemoprotein reductase
2001-04-03 Updated TERM NADPH--ferrihemoprotein reductase
2001-03-30 Added TERM NADPH--ferrihemoprotein reductase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
2007-11-08 Deleted SYNONYM NADPH:cytochrome P450 reductase
2007-11-08 Deleted SYNONYM NADPH:cytochrome c reductase
2007-11-08 Added SYNONYM NADPH-cytochrome P-450 oxidoreductase activity
2007-11-08 Added SYNONYM NADPH-cytochrome p-450 reductase activity
2007-11-08 Added SYNONYM NADPH:P-450 reductase activity
2007-11-08 Added SYNONYM NADPH:cytochrome P450 reductase activity
2007-11-08 Added SYNONYM NADPH:cytochrome c reductase activity
2007-11-08 Added SYNONYM NADPH:hemoprotein oxidoreductase activity
2007-11-08 Added SYNONYM POR
2007-11-08 Added SYNONYM TPNH2 cytochrome c reductase activity
2007-11-08 Added SYNONYM cytochrome P-450 reductase activity
2007-09-06 Added SYNONYM cytochrome P450 reductase activity
2007-09-06 Added SYNONYM cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity
2007-09-06 Added SYNONYM dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
2007-09-06 Added SYNONYM ferrihemoprotein P-450 reductase activity
2007-09-06 Added SYNONYM reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity
2007-09-06 Added SYNONYM reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity
2007-09-06 Added SYNONYM CPR activity
2007-09-06 Added SYNONYM FAD-cytochrome c reductase activity
2007-09-06 Added SYNONYM NADP--cytochrome c reductase activity
2007-09-06 Added SYNONYM NADP--cytochrome reductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome P450 oxidoreductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome P450 reductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM NADPH--cytochrome c reductase activity
2007-09-06 Added SYNONYM NADPH--ferricytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM NADPH--ferrihemoprotein reductase activity
2007-09-06 Added SYNONYM NADPH-dependent cytochrome c reductase activity
2007-09-06 Added SYNONYM NADPH:P450 reductase activity
2007-09-06 Added SYNONYM NADPH:ferrihemoprotein oxidoreductase activity
2007-09-06 Added SYNONYM TPNH(2) cytochrome c reductase activity
2007-09-06 Added SYNONYM TPNH-cytochrome c reductase activity
2007-09-06 Added SYNONYM aldehyde reductase (NADPH-dependent) activity
2007-08-09 Added SYNONYM NADPH-ferrihemoprotein reductase activity
2007-08-09 Added SYNONYM NADPH:cytochrome P450 reductase
2007-08-09 Added SYNONYM NADPH:cytochrome c reductase
2007-08-09 Deleted SYNONYM NADPH-ferrihemoprotein reductase activity
2007-08-09 Deleted SYNONYM NADPH:cytochrome P450 reductase
2007-08-09 Deleted SYNONYM NADPH:cytochrome c reductase
2006-02-04 Updated DEFINITION Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
2004-04-19 Added SYNONYM NADPH-ferrihemoprotein reductase activity
2004-04-19 Added SYNONYM NADPH:cytochrome P450 reductase
2004-04-19 Added SYNONYM NADPH:cytochrome c reductase
2004-04-16 Deleted SYNONYM NADPH-ferrihemoprotein reductase activity
2004-04-16 Deleted SYNONYM NADPH:cytochrome P450 reductase
2004-04-16 Deleted SYNONYM NADPH:cytochrome c reductase
2004-01-07 Added SYNONYM NADPH-ferrihemoprotein reductase activity
2003-10-27 Added SYNONYM NADPH:cytochrome P450 reductase
2003-10-27 Added SYNONYM NADPH:cytochrome c reductase
2003-08-21 Deleted SYNONYM NADPH:cytochrome P450 reductase
2003-08-21 Deleted SYNONYM NADPH:cytochrome c reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome = NADP+ + 2 ferrocytochrome.
2001-03-30 Added SYNONYM NADPH:cytochrome P450 reductase
2001-03-30 Added SYNONYM NADPH:cytochrome c reductase

Relationships

Timestamp Action Category Detail
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
2001-03-30 Added XREF EC:1.6.2.4
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