spacer

GO:0003954 NADH dehydrogenase activity

Term Information

ID GO:0003954
Name NADH dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
GONUTS GO:0003954 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NADH2 dehydrogenase activity
exact NADH:(acceptor) oxidoreductase activity
exact NADH:acceptor oxidoreductase activity
exact diphosphopyridine diaphorase activity
exact beta-NADH dehydrogenase dinucleotide activity
related cytochrome c reductase activity
broad diaphorase activity
exact dihydrocodehydrogenase I dehydrogenase activity
exact dihydronicotinamide adenine dinucleotide dehydrogenase activity
exact diphosphopyrinase activity
exact reduced diphosphopyridine nucleotide diaphorase activity
related type 1 dehydrogenase activity
related type I dehydrogenase activity
exact DPNH diaphorase activity
exact NADH diaphorase activity
exact NADH hydrogenase activity
exact NADH oxidoreductase activity
narrow NADH-menadione oxidoreductase activity
narrow NADH:cytochrome c oxidoreductase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.6.99.3
InterPro IPR008698
InterPro IPR008699
InterPro IPR012575
MetaCyc NADH-DEHYDROGENASE-RXN
RHEA 11359

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003954:
Relationship To GO:0003954 Child Term Child Term Name
Is a GO:0050136 NADH dehydrogenase (quinone) activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003954. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003954 based on the entire annotation set Co-occurrence statistics for GO:0003954 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:11359
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016651 (oxidoreductase activity, acting on NAD(P)H)
2007-11-08 Added SYNONYM NADH2 dehydrogenase activity
2007-11-08 Added SYNONYM NADH:(acceptor) oxidoreductase activity
2007-11-08 Added SYNONYM NADH:acceptor oxidoreductase activity
2007-11-08 Added SYNONYM diphosphopyridine diaphorase activity
2007-09-06 Deleted SYNONYM cytochrome c reductase
2007-09-06 Added SYNONYM DPNH diaphorase activity
2007-09-06 Added SYNONYM NADH diaphorase activity
2007-09-06 Added SYNONYM NADH hydrogenase activity
2007-09-06 Added SYNONYM NADH oxidoreductase activity
2007-09-06 Added SYNONYM NADH-menadione oxidoreductase activity
2007-09-06 Added SYNONYM NADH:cytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM beta-NADH dehydrogenase dinucleotide activity
2007-09-06 Added SYNONYM cytochrome c reductase activity
2007-09-06 Added SYNONYM diaphorase activity
2007-09-06 Added SYNONYM dihydrocodehydrogenase I dehydrogenase activity
2007-09-06 Added SYNONYM dihydronicotinamide adenine dinucleotide dehydrogenase activity
2007-09-06 Added SYNONYM diphosphopyrinase activity
2007-09-06 Added SYNONYM reduced diphosphopyridine nucleotide diaphorase activity
2007-09-06 Added SYNONYM type 1 dehydrogenase activity
2007-09-06 Added SYNONYM type I dehydrogenase activity
2007-08-09 Added SYNONYM cytochrome c reductase
2007-08-09 Deleted SYNONYM cytochrome c reductase
2004-04-19 Added SYNONYM cytochrome c reductase
2004-04-16 Deleted SYNONYM cytochrome c reductase
2003-10-27 Added SYNONYM cytochrome c reductase
2003-10-27 Added XREF MetaCyc:NADH-DEHYDROGENASE-RXN
2003-08-21 Deleted SYNONYM cytochrome c reductase
2003-03-19 Updated TERM NADH dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2002-05-21 Updated TERM NADH dehydrogenase
2002-04-24 Added SYNONYM cytochrome c reductase
2002-03-31 Updated TERM NADH2 dehydrogenase
2002-02-06 Updated TERM NADH dehydrogenase
2001-08-21 Updated TERM NADH dehydrogenase
2001-04-03 Updated TERM NADH2 dehydrogenase
2001-03-30 Added XREF EC:1.6.99.3
2001-03-30 Added TERM NADH2 dehydrogenase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM NADH dehydrogenase activity
2002-05-21 Updated TERM NADH dehydrogenase
2002-03-31 Updated TERM NADH2 dehydrogenase
2002-02-06 Updated TERM NADH dehydrogenase
2001-08-21 Updated TERM NADH dehydrogenase
2001-04-03 Updated TERM NADH2 dehydrogenase
2001-03-30 Added TERM NADH2 dehydrogenase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2007-11-08 Added SYNONYM NADH2 dehydrogenase activity
2007-11-08 Added SYNONYM NADH:(acceptor) oxidoreductase activity
2007-11-08 Added SYNONYM NADH:acceptor oxidoreductase activity
2007-11-08 Added SYNONYM diphosphopyridine diaphorase activity
2007-09-06 Deleted SYNONYM cytochrome c reductase
2007-09-06 Added SYNONYM DPNH diaphorase activity
2007-09-06 Added SYNONYM NADH diaphorase activity
2007-09-06 Added SYNONYM NADH hydrogenase activity
2007-09-06 Added SYNONYM NADH oxidoreductase activity
2007-09-06 Added SYNONYM NADH-menadione oxidoreductase activity
2007-09-06 Added SYNONYM NADH:cytochrome c oxidoreductase activity
2007-09-06 Added SYNONYM beta-NADH dehydrogenase dinucleotide activity
2007-09-06 Added SYNONYM cytochrome c reductase activity
2007-09-06 Added SYNONYM diaphorase activity
2007-09-06 Added SYNONYM dihydrocodehydrogenase I dehydrogenase activity
2007-09-06 Added SYNONYM dihydronicotinamide adenine dinucleotide dehydrogenase activity
2007-09-06 Added SYNONYM diphosphopyrinase activity
2007-09-06 Added SYNONYM reduced diphosphopyridine nucleotide diaphorase activity
2007-09-06 Added SYNONYM type 1 dehydrogenase activity
2007-09-06 Added SYNONYM type I dehydrogenase activity
2007-08-09 Added SYNONYM cytochrome c reductase
2007-08-09 Deleted SYNONYM cytochrome c reductase
2004-04-19 Added SYNONYM cytochrome c reductase
2004-04-16 Deleted SYNONYM cytochrome c reductase
2003-10-27 Added SYNONYM cytochrome c reductase
2003-08-21 Deleted SYNONYM cytochrome c reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.
2002-04-24 Added SYNONYM cytochrome c reductase

Relationships

Timestamp Action Category Detail
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0016651 (oxidoreductase activity, acting on NAD(P)H)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:11359
2003-10-27 Added XREF MetaCyc:NADH-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.6.99.3
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
13ms