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GO:0003934 GTP cyclohydrolase I activity

Term Information

ID GO:0003934
Name GTP cyclohydrolase I activity
Ontology Molecular Function
Definition Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
GONUTS GO:0003934 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact guanosine triphosphate cyclohydrolase activity
exact GTP 7,8-8,9-dihydrolase activity
exact guanosine triphosphate 8-deformylase activity
exact dihydroneopterin triphosphate synthase activity
exact GTP 8-formylhydrolase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.5.4.16
InterPro IPR001474
InterPro IPR018234
InterPro IPR022838
KEGG R00424
MetaCyc GTP-CYCLOHYDRO-I-RXN
RHEA 17476

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003934:
Relationship To GO:0003934 Child Term Child Term Name
Regulates GO:0043095 regulation of GTP cyclohydrolase I activity
Positively regulates GO:0043104 positive regulation of GTP cyclohydrolase I activity
Negatively regulates GO:0043105 negative regulation of GTP cyclohydrolase I activity
Regulates GO:0060308 GTP cyclohydrolase I regulator activity

Protein Annotation

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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003934. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003934 based on the entire annotation set Co-occurrence statistics for GO:0003934 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-08-18 Deleted DEFINITION Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+.
2012-08-18 Added DEFINITION Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
2011-09-16 Added XREF RHEA:17476
2010-09-03 Added XREF KEGG:R00424
2010-09-03 Deleted DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2010-09-03 Added DEFINITION Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2008-04-01 Updated RELATION is a GO:0003933 (GTP cyclohydrolase activity)
2007-11-08 Added SYNONYM GTP 7,8-8,9-dihydrolase activity
2007-11-08 Added SYNONYM GTP 8-formylhydrolase activity
2007-11-08 Added SYNONYM dihydroneopterin triphosphate synthase activity
2007-11-08 Added SYNONYM guanosine triphosphate 8-deformylase activity
2007-11-08 Added SYNONYM guanosine triphosphate cyclohydrolase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2003-10-27 Added XREF MetaCyc:GTP-CYCLOHYDRO-I-RXN
2003-03-19 Updated TERM GTP cyclohydrolase I activity
2002-11-27 Added DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate.
2002-02-06 Updated TERM GTP cyclohydrolase I
2001-04-03 Updated TERM GTP cyclohydrolase I
2001-03-30 Added XREF EC:3.5.4.16
2001-03-30 Added TERM GTP cyclohydrolase I

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM GTP cyclohydrolase I activity
2002-02-06 Updated TERM GTP cyclohydrolase I
2001-04-03 Updated TERM GTP cyclohydrolase I
2001-03-30 Added TERM GTP cyclohydrolase I

Definition/synonyms

Timestamp Action Category Detail
2012-08-18 Deleted DEFINITION Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+.
2012-08-18 Added DEFINITION Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2010-09-03 Added DEFINITION Catalysis of the reaction: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2007-11-08 Added SYNONYM GTP 7,8-8,9-dihydrolase activity
2007-11-08 Added SYNONYM GTP 8-formylhydrolase activity
2007-11-08 Added SYNONYM dihydroneopterin triphosphate synthase activity
2007-11-08 Added SYNONYM guanosine triphosphate 8-deformylase activity
2007-11-08 Added SYNONYM guanosine triphosphate cyclohydrolase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
2002-11-27 Added DEFINITION Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003933 (GTP cyclohydrolase activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:17476
2010-09-03 Added XREF KEGG:R00424
2003-10-27 Added XREF MetaCyc:GTP-CYCLOHYDRO-I-RXN
2001-03-30 Added XREF EC:3.5.4.16
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