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GO:0003924 GTPase activity

Term Information

ID GO:0003924
Name GTPase activity
Ontology Molecular Function
Definition Catalysis of the reaction: GTP + H2O = GDP + phosphate.
GONUTS GO:0003924 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow small monomeric GTPase activity
narrow tubulin GTPase activity
narrow signal-recognition-particle GTPase activity
narrow protein-synthesizing GTPase activity, termination
narrow protein-synthesizing GTPase activity, initiation
narrow Rab small monomeric GTPase activity
narrow Ran small monomeric GTPase activity
narrow Ras small monomeric GTPase activity
narrow Sar small monomeric GTPase activity
narrow ARF small monomeric GTPase activity
narrow RHEB small monomeric GTPase activity
narrow Rho small monomeric GTPase activity
narrow dynamin GTPase activity
narrow heterotrimeric G-protein GTPase activity
related heterotrimeric G-protein GTPase, alpha-subunit
related heterotrimeric G-protein GTPase, beta-subunit
related heterotrimeric G-protein GTPase, gamma-subunit
broad hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
narrow protein-synthesizing GTPase activity
narrow protein-synthesizing GTPase activity, elongation

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_chembl309
goslim_yeast168
goslim_generic149

Cross-references

Database ID
InterPro IPR000367
InterPro IPR000469
InterPro IPR000654
InterPro IPR000795
InterPro IPR001019
InterPro IPR001401
InterPro IPR001408
InterPro IPR001806
InterPro IPR002041
InterPro IPR002975
InterPro IPR003008
InterPro IPR003130
InterPro IPR003191
InterPro IPR004400
InterPro IPR004520
InterPro IPR004780
InterPro IPR004881
InterPro IPR005129
InterPro IPR006325
InterPro IPR006884
InterPro IPR007222
InterPro IPR010914
InterPro IPR012202
InterPro IPR014100
InterPro IPR015894
InterPro IPR020006
InterPro IPR020860
InterPro IPR021181
InterPro IPR022941
InterPro IPR027088
InterPro IPR027089
InterPro IPR027091
InterPro IPR027094
InterPro IPR027188
InterPro IPR027741
InterPro IPR028412
InterPro IPR030230
InterPro IPR030556
InterPro IPR030697
InterPro IPR030702
InterPro IPR033047
InterPro IPR033669
InterPro IPR034114
RHEA 19672

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0000263 obsolete heterotrimeric G-protein GTPase, alpha-subunit CONSIDER GO:0003924
GO:0000264 obsolete heterotrimeric G-protein GTPase, beta-subunit CONSIDER GO:0003924
GO:0000265 obsolete heterotrimeric G-protein GTPase, gamma-subunit CONSIDER GO:0003924
GO:0003927 obsolete heterotrimeric G-protein GTPase activity CONSIDER GO:0003924
GO:0006184 obsolete GTP catabolic process CONSIDER GO:0003924
GO:0008547 obsolete protein-synthesizing GTPase activity CONSIDER GO:0003924
GO:0008548 obsolete signal-recognition-particle GTPase activity CONSIDER GO:0003924
GO:0008550 obsolete tubulin GTPase activity CONSIDER GO:0003924
GO:0016146 obsolete protein-synthesizing GTPase activity, initiation CONSIDER GO:0003924
GO:0016147 obsolete protein-synthesizing GTPase activity, elongation CONSIDER GO:0003924
GO:0016148 obsolete protein-synthesizing GTPase activity, termination CONSIDER GO:0003924
GO:0050800 obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement CONSIDER GO:0003924
GO:0003925 obsolete small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0003926 obsolete ARF small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0003928 obsolete RAB small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0003929 obsolete RAN small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0003930 obsolete RAS small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0003931 obsolete Rho small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0003932 obsolete SAR small monomeric GTPase activity REPLACEDBY GO:0003924
GO:0008549 obsolete dynamin GTPase activity REPLACEDBY GO:0003924
GO:0008619 obsolete RHEB small monomeric GTPase activity REPLACEDBY GO:0003924

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003924:
Relationship To GO:0003924 Child Term Child Term Name
Negatively regulates GO:0005095 GTPase inhibitor activity
Positively regulates GO:0005096 GTPase activator activity
Regulates GO:0030695 GTPase regulator activity
Negatively regulates GO:0034260 negative regulation of GTPase activity
Regulates GO:0043087 regulation of GTPase activity
Positively regulates GO:0043547 positive regulation of GTPase activity
Capable of GO:1905360 GTPase complex
Is a GO:0061791 GTPase motor activity
Capable of GO:0005834 heterotrimeric G-protein complex
Is a GO:0061745 GTPase activity, coupled

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003924. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003924 based on the entire annotation set Co-occurrence statistics for GO:0003924 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-07-23 Deleted SLIM goslim_metagenomics
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2014-12-20 Deleted RELATION part of GO:0006184 (obsolete GTP catabolic process)
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-09-14 Added XREF RHEA:19672
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-08-14 Added SLIM goslim_yeast
2010-06-15 Added RELATION part of GO:0006184 (obsolete GTP catabolic process)
2010-06-14 Deleted RELATION part of GO:0006184 (obsolete GTP catabolic process)
2010-06-08 Added RELATION part of GO:0006184 (obsolete GTP catabolic process)
2008-05-13 Added DEFINITION Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2008-04-01 Updated RELATION is a GO:0017111 (nucleoside-triphosphatase activity)
2007-10-11 Deleted SYNONYM RAB small monomeric GTPase activity
2007-10-11 Deleted SYNONYM RAN small monomeric GTPase activity
2007-10-11 Deleted SYNONYM RAS small monomeric GTPase activity
2007-10-11 Deleted SYNONYM SAR small monomeric GTPase activity
2007-10-11 Added SYNONYM Rab small monomeric GTPase activity
2007-10-11 Added SYNONYM Ran small monomeric GTPase activity
2007-10-11 Added SYNONYM Ras small monomeric GTPase activity
2007-10-11 Added SYNONYM Sar small monomeric GTPase activity
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase, gamma-subunit
2007-08-09 Added SYNONYM hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity, elongation
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity, initiation
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity, termination
2007-08-09 Added SYNONYM signal-recognition-particle GTPase activity
2007-08-09 Added SYNONYM small monomeric GTPase activity
2007-08-09 Added SYNONYM tubulin GTPase activity
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase, beta-subunit
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase activity
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase, alpha-subunit
2007-08-09 Added SYNONYM RAB small monomeric GTPase activity
2007-08-09 Added SYNONYM RAN small monomeric GTPase activity
2007-08-09 Added SYNONYM RAS small monomeric GTPase activity
2007-08-09 Added SYNONYM RHEB small monomeric GTPase activity
2007-08-09 Added SYNONYM Rho small monomeric GTPase activity
2007-08-09 Added SYNONYM SAR small monomeric GTPase activity
2007-08-09 Added SYNONYM dynamin GTPase activity
2007-08-09 Added SYNONYM ARF small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RHEB small monomeric GTPase activity
2007-08-09 Deleted SYNONYM Rho small monomeric GTPase activity
2007-08-09 Deleted SYNONYM SAR small monomeric GTPase activity
2007-08-09 Deleted SYNONYM dynamin GTPase activity
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase activity
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase, alpha-subunit
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase, beta-subunit
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase, gamma-subunit
2007-08-09 Deleted SYNONYM hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity, elongation
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity, initiation
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity, termination
2007-08-09 Deleted SYNONYM signal-recognition-particle GTPase activity
2007-08-09 Deleted SYNONYM small monomeric GTPase activity
2007-08-09 Deleted SYNONYM tubulin GTPase activity
2007-08-09 Deleted SYNONYM ARF small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RAB small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RAN small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RAS small monomeric GTPase activity
2005-08-10 Added SYNONYM RAS small monomeric GTPase activity
2005-08-10 Added SYNONYM RHEB small monomeric GTPase activity
2005-08-10 Added SYNONYM Rho small monomeric GTPase activity
2005-08-10 Added SYNONYM SAR small monomeric GTPase activity
2005-08-10 Added SYNONYM dynamin GTPase activity
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase activity
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase, alpha-subunit
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase, beta-subunit
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase, gamma-subunit
2005-08-10 Added SYNONYM hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, elongation
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, initiation
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, termination
2005-08-10 Added SYNONYM signal-recognition-particle GTPase activity
2005-08-10 Added SYNONYM small monomeric GTPase activity
2005-08-10 Added SYNONYM tubulin GTPase activity
2005-08-10 Added SYNONYM ARF small monomeric GTPase activity
2005-08-10 Added SYNONYM RAB small monomeric GTPase activity
2005-08-10 Added SYNONYM RAN small monomeric GTPase activity
2004-09-15 Updated DEFINITION Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2004-03-19 Deleted XREF EC:3.6.-.-
2004-01-07 Added XREF EC:3.6.-.-
2004-01-07 Deleted XREF EC:3.6.1.-
2003-08-06 Updated DEFINITION Catalysis of the hydrolysis of GTP to GDP and orthophosphate.
2003-03-19 Updated TERM GTPase activity
2002-11-27 Updated DEFINITION Any enzymatic activity that hydrolyzes GTP to GDP and orthophosphate.
2002-02-06 Updated TERM GTPase
2001-08-06 Added DEFINITION Any enzymic activity that hydrolyzes GTP to GDP and orthophosphate.
2001-04-03 Updated TERM GTPase
2001-03-30 Added XREF EC:3.6.1.-
2001-03-30 Added TERM GTPase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM GTPase activity
2002-02-06 Updated TERM GTPase
2001-04-03 Updated TERM GTPase
2001-03-30 Added TERM GTPase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2007-10-11 Deleted SYNONYM RAB small monomeric GTPase activity
2007-10-11 Deleted SYNONYM RAN small monomeric GTPase activity
2007-10-11 Deleted SYNONYM RAS small monomeric GTPase activity
2007-10-11 Deleted SYNONYM SAR small monomeric GTPase activity
2007-10-11 Added SYNONYM Rab small monomeric GTPase activity
2007-10-11 Added SYNONYM Ran small monomeric GTPase activity
2007-10-11 Added SYNONYM Ras small monomeric GTPase activity
2007-10-11 Added SYNONYM Sar small monomeric GTPase activity
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase, gamma-subunit
2007-08-09 Added SYNONYM hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity, elongation
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity, initiation
2007-08-09 Added SYNONYM protein-synthesizing GTPase activity, termination
2007-08-09 Added SYNONYM signal-recognition-particle GTPase activity
2007-08-09 Added SYNONYM small monomeric GTPase activity
2007-08-09 Added SYNONYM tubulin GTPase activity
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase, beta-subunit
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase activity
2007-08-09 Added SYNONYM heterotrimeric G-protein GTPase, alpha-subunit
2007-08-09 Added SYNONYM RAB small monomeric GTPase activity
2007-08-09 Added SYNONYM RAN small monomeric GTPase activity
2007-08-09 Added SYNONYM RAS small monomeric GTPase activity
2007-08-09 Added SYNONYM RHEB small monomeric GTPase activity
2007-08-09 Added SYNONYM Rho small monomeric GTPase activity
2007-08-09 Added SYNONYM SAR small monomeric GTPase activity
2007-08-09 Added SYNONYM dynamin GTPase activity
2007-08-09 Added SYNONYM ARF small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RHEB small monomeric GTPase activity
2007-08-09 Deleted SYNONYM Rho small monomeric GTPase activity
2007-08-09 Deleted SYNONYM SAR small monomeric GTPase activity
2007-08-09 Deleted SYNONYM dynamin GTPase activity
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase activity
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase, alpha-subunit
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase, beta-subunit
2007-08-09 Deleted SYNONYM heterotrimeric G-protein GTPase, gamma-subunit
2007-08-09 Deleted SYNONYM hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity, elongation
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity, initiation
2007-08-09 Deleted SYNONYM protein-synthesizing GTPase activity, termination
2007-08-09 Deleted SYNONYM signal-recognition-particle GTPase activity
2007-08-09 Deleted SYNONYM small monomeric GTPase activity
2007-08-09 Deleted SYNONYM tubulin GTPase activity
2007-08-09 Deleted SYNONYM ARF small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RAB small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RAN small monomeric GTPase activity
2007-08-09 Deleted SYNONYM RAS small monomeric GTPase activity
2005-08-10 Added SYNONYM RAS small monomeric GTPase activity
2005-08-10 Added SYNONYM RHEB small monomeric GTPase activity
2005-08-10 Added SYNONYM Rho small monomeric GTPase activity
2005-08-10 Added SYNONYM SAR small monomeric GTPase activity
2005-08-10 Added SYNONYM dynamin GTPase activity
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase activity
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase, alpha-subunit
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase, beta-subunit
2005-08-10 Added SYNONYM heterotrimeric G-protein GTPase, gamma-subunit
2005-08-10 Added SYNONYM hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, elongation
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, initiation
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, termination
2005-08-10 Added SYNONYM signal-recognition-particle GTPase activity
2005-08-10 Added SYNONYM small monomeric GTPase activity
2005-08-10 Added SYNONYM tubulin GTPase activity
2005-08-10 Added SYNONYM ARF small monomeric GTPase activity
2005-08-10 Added SYNONYM RAB small monomeric GTPase activity
2005-08-10 Added SYNONYM RAN small monomeric GTPase activity
2004-09-15 Updated DEFINITION Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2003-08-06 Updated DEFINITION Catalysis of the hydrolysis of GTP to GDP and orthophosphate.
2002-11-27 Updated DEFINITION Any enzymatic activity that hydrolyzes GTP to GDP and orthophosphate.
2001-08-06 Added DEFINITION Any enzymic activity that hydrolyzes GTP to GDP and orthophosphate.

Relationships

Timestamp Action Category Detail
2014-12-20 Deleted RELATION part of GO:0006184 (obsolete GTP catabolic process)
2010-06-15 Added RELATION part of GO:0006184 (obsolete GTP catabolic process)
2010-06-14 Deleted RELATION part of GO:0006184 (obsolete GTP catabolic process)
2010-06-08 Added RELATION part of GO:0006184 (obsolete GTP catabolic process)
2008-04-01 Updated RELATION is a GO:0017111 (nucleoside-triphosphatase activity)

Cross-references

Timestamp Action Category Detail
2012-09-14 Added XREF RHEA:19672
2004-03-19 Deleted XREF EC:3.6.-.-
2004-01-07 Added XREF EC:3.6.-.-
2004-01-07 Deleted XREF EC:3.6.1.-
2001-03-30 Added XREF EC:3.6.1.-

Other

Timestamp Action Category Detail
2016-07-23 Deleted SLIM goslim_metagenomics
2015-05-19 Added SLIM goslim_chembl
2015-05-19 Deleted SLIM goslim_ChEMBL
2015-05-11 Added SLIM goslim_ChEMBL
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-08-14 Added SLIM goslim_yeast
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