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GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activityCatalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Term Information
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| Type | Synonym |
| exact | type II DNA topoisomerase activity |
| exact | topoisomerase II |
| exact | DNA topoisomerase IV activity |
| exact | DNA topoisomerase type II activity |
| exact | DNA-gyrase activity |
| broad | deoxyribonucleate topoisomerase |
| exact | deoxyribonucleic topoisomerase activity |
| broad | topoisomerase |
| exact | DNA gyrase activity |
| related | DNA topoisomerase II |
| broad | DNA topoisomerase (ATP-hydrolysing) |
| Database | ID |
| INTERPRO | IPR012542 |
| EC | 5.99.1.3 |
| MetaCyc | 5.99.1.3-RXN |
| Wikipedia | Type_II_topoisomerase |
| INTERPRO | IPR013757 |
| INTERPRO | IPR013758 |
| INTERPRO | IPR013759 |
| INTERPRO | IPR013760 |
| INTERPRO | IPR018522 |
| INTERPRO | IPR005734 |
| INTERPRO | IPR005737 |
| INTERPRO | IPR005740 |
| INTERPRO | IPR005741 |
| INTERPRO | IPR005742 |
| INTERPRO | IPR005743 |
| INTERPRO | IPR015320 |
| INTERPRO | IPR004085 |
| INTERPRO | IPR001154 |
| INTERPRO | IPR011557 |
| INTERPRO | IPR013263 |
| INTERPRO | IPR013500 |
| INTERPRO | IPR013506 |
| INTERPRO | IPR001241 |
| INTERPRO | IPR000565 |
| INTERPRO | IPR002288 |
| INTERPRO | IPR002205 |
GO:0008724 DNA topoisomerase IV activity |
(replaced_by GO:0003918) |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||||
![]() | GO:0005488 binding | ||||||
![]() | ![]() | GO:0003824 catalytic activity | |||||
![]() | ![]() | ![]() | GO:0016853 isomerase activity | ||||
![]() | ![]() | ![]() | ![]() | GO:0003676 nucleic acid binding | |||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0003677 DNA binding | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0003916 DNA topoisomerase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| Hostname | tomcat-8.ebi.ac.uk |
| Uptime | 17:46 13/10/2009 |
| Data version | 2009-11-20-04-03-08 |