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GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity

Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

Term Information

ID GO:0003918
Name DNA topoisomerase (ATP-hydrolyzing) activity
Ontology Molecular Function
Definition Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Comment

Synonyms

Type Synonym
exact type II DNA topoisomerase activity
exact topoisomerase II
exact DNA topoisomerase IV activity
exact DNA topoisomerase type II activity
exact DNA-gyrase activity
broad deoxyribonucleate topoisomerase
exact deoxyribonucleic topoisomerase activity
broad topoisomerase
exact DNA gyrase activity
related DNA topoisomerase II
broad DNA topoisomerase (ATP-hydrolysing)

Cross-references associated with this term:

Database ID
INTERPRO IPR012542
EC 5.99.1.3
MetaCyc 5.99.1.3-RXN
Wikipedia Type_II_topoisomerase
INTERPRO IPR013757
INTERPRO IPR013758
INTERPRO IPR013759
INTERPRO IPR013760
INTERPRO IPR018522
INTERPRO IPR005734
INTERPRO IPR005737
INTERPRO IPR005740
INTERPRO IPR005741
INTERPRO IPR005742
INTERPRO IPR005743
INTERPRO IPR015320
INTERPRO IPR004085
INTERPRO IPR001154
INTERPRO IPR011557
INTERPRO IPR013263
INTERPRO IPR013500
INTERPRO IPR013506
INTERPRO IPR001241
INTERPRO IPR000565
INTERPRO IPR002288
INTERPRO IPR002205

This term can be used instead of these obsolete terms:

GO:0008724 DNA topoisomerase IV activity (replaced_by GO:0003918)

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Ancestor Chart

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Ancestor Table

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GO:0003674 molecular_function
GO:0005488 binding
GO:0003824 catalytic activity
GO:0016853 isomerase activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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