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GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity

Term Information

ID GO:0003918
Name DNA topoisomerase type II (ATP-hydrolyzing) activity
Ontology Molecular Function
Definition Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
PMID:8811192
GONUTS GO:0003918 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related DNA topoisomerase II
related topoisomerase II
related DNA topoisomerase type II activity
broad topoisomerase
exact deoxyribonucleic topoisomerase activity
broad deoxyribonucleate topoisomerase
exact DNA-gyrase activity
exact DNA topoisomerase IV activity
exact DNA gyrase activity
broad DNA topoisomerase (ATP-hydrolysing)
exact type II DNA topoisomerase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 5.99.1.3
InterPro IPR000565
InterPro IPR001154
InterPro IPR001241
InterPro IPR002205
InterPro IPR002288
InterPro IPR004085
InterPro IPR005734
InterPro IPR005737
InterPro IPR005740
InterPro IPR005741
InterPro IPR005742
InterPro IPR005743
InterPro IPR011557
InterPro IPR012542
InterPro IPR013263
InterPro IPR013500
InterPro IPR013506
InterPro IPR013757
InterPro IPR013758
InterPro IPR013759
InterPro IPR013760
InterPro IPR015320
InterPro IPR018522
InterPro IPR028466
InterPro IPR028467
MetaCyc 5.99.1.3-RXN
Wikipedia Type_II_topoisomerase

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008724 DNA topoisomerase IV activity REPLACEDBY GO:0003918

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003918:
Relationship To GO:0003918 Child Term Child Term Name
Negatively regulates GO:0008657 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
Regulates GO:0072586 DNA topoisomerase (ATP-hydrolyzing) regulator activity
Positively regulates GO:0072587 DNA topoisomerase (ATP-hydrolyzing) activator activity
Regulates GO:2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Negatively regulates GO:2000372 negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Positively regulates GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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ID Mapping

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0003918. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0003918 based on the entire annotation set Co-occurrence statistics for GO:0003918 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-01-25 Updated TERM DNA topoisomerase type II (ATP-hydrolyzing) activity
2013-01-25 Deleted SYNONYM DNA topoisomerase type II activity
2013-01-25 Deleted SYNONYM topoisomerase II
2013-01-25 Added SYNONYM DNA topoisomerase type II activity
2013-01-25 Added SYNONYM topoisomerase II
2013-01-25 Added RELATION is a GO:0061505 (DNA topoisomerase II activity)
2013-01-25 Deleted RELATION is a GO:0003916 (DNA topoisomerase activity)
2011-08-12 Added RELATION is a GO:0008094 (DNA-dependent ATPase activity)
2009-02-25 Added XREF Wikipedia:Type_II_topoisomerase
2009-01-29 Deleted SYNONYM DNA gyrase activity
2009-01-29 Added SYNONYM DNA gyrase activity
2008-05-13 Added DEFINITION Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2008-05-12 Deleted DEFINITION Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2008-04-01 Updated RELATION is a GO:0003916 (DNA topoisomerase activity)
2007-11-08 Added SYNONYM DNA topoisomerase (ATP-hydrolysing)
2007-11-08 Added SYNONYM DNA topoisomerase II
2007-11-08 Added SYNONYM DNA-gyrase activity
2007-11-08 Added SYNONYM deoxyribonucleate topoisomerase
2007-11-08 Added SYNONYM deoxyribonucleic topoisomerase activity
2007-11-08 Added SYNONYM topoisomerase
2007-09-06 Added SYNONYM type II DNA topoisomerase activity
2007-08-09 Added SYNONYM DNA gyrase activity
2007-08-09 Added SYNONYM DNA topoisomerase IV activity
2007-08-09 Added SYNONYM DNA topoisomerase type II activity
2007-08-09 Added SYNONYM topoisomerase II
2007-08-09 Deleted SYNONYM DNA gyrase activity
2007-08-09 Deleted SYNONYM DNA topoisomerase IV activity
2007-08-09 Deleted SYNONYM DNA topoisomerase type II activity
2007-08-09 Deleted SYNONYM topoisomerase II
2005-08-10 Added SYNONYM DNA topoisomerase IV activity
2004-04-19 Added SYNONYM DNA gyrase activity
2004-04-19 Added SYNONYM DNA topoisomerase type II activity
2004-04-19 Added SYNONYM topoisomerase II
2004-04-16 Deleted SYNONYM DNA gyrase activity
2004-04-16 Deleted SYNONYM DNA topoisomerase type II activity
2004-04-16 Deleted SYNONYM topoisomerase II
2004-01-07 Updated TERM DNA topoisomerase (ATP-hydrolyzing) activity
2004-01-07 Deleted SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2004-01-07 Added SYNONYM DNA topoisomerase type II activity
2003-10-27 Added SYNONYM DNA gyrase activity
2003-10-27 Added SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2003-10-27 Added SYNONYM topoisomerase II
2003-10-27 Added XREF MetaCyc:5.99.1.3-RXN
2003-08-18 Deleted SYNONYM DNA gyrase activity
2003-08-18 Deleted SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2003-08-18 Deleted SYNONYM topoisomerase II
2003-08-06 Updated DEFINITION Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2003-04-15 Updated DEFINITION Catalysis of DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2003-04-15 Added SYNONYM DNA gyrase activity
2003-04-15 Added SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2003-04-15 Updated TERM DNA topoisomerase type II activity
2003-03-19 Updated TERM DNA topoisomerase (ATP-hydrolyzing) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP-dependent breakage, passage and rejoining of double-stranded DNA.
2002-02-06 Updated TERM DNA topoisomerase (ATP-hydrolyzing)
2001-04-03 Updated TERM DNA topoisomerase (ATP-hydrolyzing)
2001-03-30 Added XREF EC:5.99.1.3
2001-03-30 Added SYNONYM topoisomerase II
2001-03-30 Added TERM DNA topoisomerase (ATP-hydrolyzing)

Term

Timestamp Action Category Detail
2013-01-25 Updated TERM DNA topoisomerase type II (ATP-hydrolyzing) activity
2004-01-07 Updated TERM DNA topoisomerase (ATP-hydrolyzing) activity
2003-04-15 Updated TERM DNA topoisomerase type II activity
2003-03-19 Updated TERM DNA topoisomerase (ATP-hydrolyzing) activity
2002-02-06 Updated TERM DNA topoisomerase (ATP-hydrolyzing)
2001-04-03 Updated TERM DNA topoisomerase (ATP-hydrolyzing)
2001-03-30 Added TERM DNA topoisomerase (ATP-hydrolyzing)

Definition/synonyms

Timestamp Action Category Detail
2013-01-25 Deleted SYNONYM DNA topoisomerase type II activity
2013-01-25 Deleted SYNONYM topoisomerase II
2013-01-25 Added SYNONYM DNA topoisomerase type II activity
2013-01-25 Added SYNONYM topoisomerase II
2009-01-29 Deleted SYNONYM DNA gyrase activity
2009-01-29 Added SYNONYM DNA gyrase activity
2008-05-13 Added DEFINITION Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2008-05-12 Deleted DEFINITION Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2007-11-08 Added SYNONYM DNA topoisomerase (ATP-hydrolysing)
2007-11-08 Added SYNONYM DNA topoisomerase II
2007-11-08 Added SYNONYM DNA-gyrase activity
2007-11-08 Added SYNONYM deoxyribonucleate topoisomerase
2007-11-08 Added SYNONYM deoxyribonucleic topoisomerase activity
2007-11-08 Added SYNONYM topoisomerase
2007-09-06 Added SYNONYM type II DNA topoisomerase activity
2007-08-09 Added SYNONYM DNA gyrase activity
2007-08-09 Added SYNONYM DNA topoisomerase IV activity
2007-08-09 Added SYNONYM DNA topoisomerase type II activity
2007-08-09 Added SYNONYM topoisomerase II
2007-08-09 Deleted SYNONYM DNA gyrase activity
2007-08-09 Deleted SYNONYM DNA topoisomerase IV activity
2007-08-09 Deleted SYNONYM DNA topoisomerase type II activity
2007-08-09 Deleted SYNONYM topoisomerase II
2005-08-10 Added SYNONYM DNA topoisomerase IV activity
2004-04-19 Added SYNONYM DNA gyrase activity
2004-04-19 Added SYNONYM DNA topoisomerase type II activity
2004-04-19 Added SYNONYM topoisomerase II
2004-04-16 Deleted SYNONYM DNA gyrase activity
2004-04-16 Deleted SYNONYM DNA topoisomerase type II activity
2004-04-16 Deleted SYNONYM topoisomerase II
2004-01-07 Deleted SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2004-01-07 Added SYNONYM DNA topoisomerase type II activity
2003-10-27 Added SYNONYM DNA gyrase activity
2003-10-27 Added SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2003-10-27 Added SYNONYM topoisomerase II
2003-08-18 Deleted SYNONYM DNA gyrase activity
2003-08-18 Deleted SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2003-08-18 Deleted SYNONYM topoisomerase II
2003-08-06 Updated DEFINITION Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2003-04-15 Updated DEFINITION Catalysis of DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2003-04-15 Added SYNONYM DNA gyrase activity
2003-04-15 Added SYNONYM DNA topoisomerase (ATP-hydrolyzing) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP-dependent breakage, passage and rejoining of double-stranded DNA.
2001-03-30 Added SYNONYM topoisomerase II

Relationships

Timestamp Action Category Detail
2013-01-25 Added RELATION is a GO:0061505 (DNA topoisomerase II activity)
2013-01-25 Deleted RELATION is a GO:0003916 (DNA topoisomerase activity)
2011-08-12 Added RELATION is a GO:0008094 (DNA-dependent ATPase activity)
2008-04-01 Updated RELATION is a GO:0003916 (DNA topoisomerase activity)

Cross-references

Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Type_II_topoisomerase
2003-10-27 Added XREF MetaCyc:5.99.1.3-RXN
2001-03-30 Added XREF EC:5.99.1.3
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